569 research outputs found
Cluster Variation Approach to the Random-Anisotropy Blume-Emery-Griffiths Model
The random--anisotropy Blume--Emery--Griffiths model, which has been proposed
to describe the critical behavior of He--He mixtures in a porous
medium, is studied in the pair approximation of the cluster variation method
extended to disordered systems. Several new features, with respect to mean
field theory, are found, including a rich ground state, a nonzero percolation
threshold, a reentrant coexistence curve and a miscibility gap on the high
He concentration side down to zero temperature. Furthermore, nearest
neighbor correlations are introduced in the random distribution of the
anisotropy, which are shown to be responsible for the raising of the critical
temperature with respect to the pure and uncorrelated random cases and
contribute to the detachment of the coexistence curve from the line.Comment: 14 pages (plain TeX) + 12 figures (PostScript, appended), Preprint
POLFIS-TH.02/9
Efficacy and Safety of Meropenem\u2013Vaborbactam Versus Best Available Therapy for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Patients Without Prior Antimicrobial Failure: A Post Hoc Analysis
open5siIntroduction: Infections due to Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are associated with increased morbidity and high mortality. Meropenem–vaborbactam (MV) is a novel β-lactam/β-lactamase inhibitor combination active against KPC-producing Enterobacteriaceae. The aim of this post hoc analysis of the TANGO-II randomized controlled trial was to assess the efficacy of MV versus best available therapy (BAT) in the subgroup of patients without prior antimicrobial failure. Methods: The primary outcome measure was clinical cure at the test of cure (TOC). Secondary outcome measures included (1) clinical cure at the end of therapy (EOT), (2) microbiological cure at TOC, (3) microbiological cure at EOT, and (4) 28-day all-cause mortality. Results: First-line MV was associated with a 42.9% absolute increase in clinical cure rate at TOC (95% confidence intervals [CI] 13.7–72.1) in comparison with first-line BAT. A 49.3% absolute increase in clinical cure rate at EOT (95% CI 20.8–77.7), a 42.6% absolute increase in microbiological cure rate at EOT (95% CI 13.4–71.8), and a 36.2% absolute increase in microbiologic cure rate at TOC (95% CI 5.9–66.6) were also observed, in addition to a 29.0% absolute reduction in mortality (95% CI − 54.3 to − 3.7). Overall, fewer adverse events were observed in the MV group than in the BAT group. Conclusion: MV was superior to BAT in the subgroup of patients with serious carbapenem-resistant Enterobacteriaceae (CRE) infections and no prior antimicrobial failure, with very high rates of clinical success, and was well tolerated. Post approval and real-world studies remain essential to clearly define the most appropriate population for early, empirical MV coverage, in accordance with antimicrobial stewardship principles. Funding: The Medicines Company.openBassetti M.; Giacobbe D.R.; Patel N.; Tillotson G.; Massey J.Bassetti, M.; Giacobbe, D. R.; Patel, N.; Tillotson, G.; Massey, J
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Characterization of vanadium/silica and copper/silica aerogel catalysts
Vanadium/silica and copper/silica aerogels have been prepared using the sol-gel method followed by CO{sub 2} exchange and supercritical extraction. Structural properties of samples supercritically dried, oxidized and used in reactions studies conducted with a feed representing the average composition of automobile exhaust from a lean burn engine were investigated using laser Raman spectroscopy and temperature-programmed reduction. No evidence of crystalline V{sub 2}O{sub 5} was found for the vanadium/silica aerogel, freshly extracted, oxidized or following exposure to reaction conditions using these techniques. However, results obtained for the copper/silica sample indicate that changes in the structure of the copper species had occurred as the sample was oxidized and exposed to reaction conditions
Anisotropic Aerogels for Studying Superfluid He
It may be possible to stabilize new superfluid phases of He with
anisotropic silica aerogels. We discuss two methods that introduce anisotropy
in the aerogel on length scales relevant to superfluid He. First,
anisotropy can be induced with uniaxial strain. A second method generates
anisotropy during the growth and drying stages. We have grown cylindrical
98% aerogels with anisotropy indicated by preferential radial shrinkage
after supercritical drying and find that this shrinkage correlates with small
angle x-ray scattering (SAXS). The growth-induced anisotropy was found to be
out of phase relative to that induced by strain. This has
implications for the possible stabilization of superfluid phases with specific
symmetry.Comment: 6 pages, 4 figures, submitted to Quantum Fluids and Solids (QFS)
conference 200
Method for acquiring, storing and analyzing crystal images
A system utilizing a digital computer for acquiring, storing and evaluating crystal images. The system includes a video camera (12) which produces a digital output signal representative of a crystal specimen positioned within its focal window (16). The digitized output from the camera (12) is then stored on data storage media (32) together with other parameters inputted by a technician and relevant to the crystal specimen. Preferably, the digitized images are stored on removable media (32) while the parameters for different crystal specimens are maintained in a database (40) with indices to the digitized optical images on the other data storage media (32). Computer software is then utilized to identify not only the presence and number of crystals and the edges of the crystal specimens from the optical image, but to also rate the crystal specimens by various parameters, such as edge straightness, polygon formation, aspect ratio, surface clarity, crystal cracks and other defects or lack thereof, and other parameters relevant to the quality of the crystals
Consumer Culture Theory: Development, Critique, Application and Prospects
This review takes stock of the development of Consumer Culture Theory (CCT) and provides a perspective from which this field of research can be framed, synthesized, and navigated. This review takes a conceptual and historical approach to map the rich theoretical inventory cultivated over almost 40 years of culturally-oriented research on consumption. The authors describe how CCT has emerged, chart various approaches to consumer culture studies, outline the dominant research domains, identify debates and controversies that circulate in the field, discuss the latest conceptual and methodological developments, and share managerial implications of a CCT approach. From this vantage point, they point to some promising directions for CCT research
Experimental observation and characterization of the magnetorotational instability
Differential rotation occurs in conducting flows in accretion disks and
planetary cores. In such systems, the magnetorotational instability can arise
from coupling Lorentz and centrifugal forces to cause large radial angular
momentum fluxes. We present the first experimental observation of the
magnetorotational instability. Our system consists of liquid sodium between
differentially rotating spheres, with an imposed coaxial magnetic field. We
characterize the observed patterns, dynamics and torque increases, and
establish that this instability can occur from a hydrodynamic turbulent
background.Comment: 4 pages, 5 figures. Final version, accepted for publication in
Physical Review Letter
The post-mortem resilience of facial creases and the possibility for use in identification of the dead
The post-mortem resilience of facial creases was studied using donated bodies in order to establish the
efficacy of crease analysis for identification of the dead. Creases were studied on normal (pre-embalmed)
and bloated (embalmed) cadavers at the Centre for Anatomy and Human Identification (CAHID) to
establish whether facial bloating would affect facial crease visibility. Embalming was chosen to simulate
the effects produced by post-mortem bloating. The results suggested that creases are resilient and
changes were only detected for creases located on the periphery of the face, particularly at areas where
the skin is thick, such as at the cheeks. Two new creases not previously classified were identified; these
creases were called the vertical superciliary arch line and the lateral nose crease. This research suggests
that facial creases may be resilient enough after death to be utilised for human identification
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