Quantum phases in a resonantly-interacting Bose-Fermi mixture

We consider a resonantly-interacting Bose-Fermi mixture of $^{40}$K and $^{87}$Rb atoms in an optical lattice. We show that by using a red-detuned optical lattice the mixture can be accurately described by a generalized Hubbard model for $^{40}$K and $^{87}$Rb atoms, and $^{40}$K-$^{87}$Rb molecules. The microscopic parameters of this model are fully determined by the details of the optical lattice and the interspecies Feshbach resonance in the absence of the lattice. We predict a quantum phase transition to occur in this system already at low atomic filling fraction, and present the phase diagram as a function of the temperature and the applied magnetic field.Comment: 4 pages, 3 figure

Webteaching: sequencing of subject matter in relation to prior knowledge of pupils

Two experiments are discussed in which the sequencing procedure of webteaching is compared with a linear sequence for the presentation of text material.\ud \ud In the first experiment variations in the level of prior knowledge of pupils were studied for their influence on the sequencing mode of text presentation. Prior knowledge greatly reduced the effect of the size of sequencing procedures.\ud \ud In the second experiment pupils with a low level of prior knowledge studied a text, following either a websequence or a linear sequence. Webteaching was superior to linear teaching on a number of dependent variables. It is concluded that webteaching is an effective sequencing procedure in those cases where substantial new learning is required

New highway development in the Netherlands: A residents’ perspective

This study investigates the impacts of new highway development from a residents’ perspective. Data were collected by questionnaire in two residential areas, Son and Uden, both situated along the new A50 highway in the Netherlands. The objectives of this study are: 1) to analyse the extent to which highway development has impacted the residents’ self-reported residential satisfaction through the use of Structural Equation Modeling, and 2) to explore residential self-selection, by comparing characteristics of the original population with those who have relocated into the area during and after highway development using Multinomial Logistic Regression. The results indicate that a small majority of the residents perceived an increase in residential satisfaction due to the highway development. Living in the sampled area in Son (compared to Uden), living on close proximity to the A50 highway, having a low preference for car accessibility, and a strong preference for environmental quality were negatively associated with the change in residential satisfaction, mostly via a negative association with the perceived change in liveability or accessibility. The findings of our second analysis show that residents who had relocated into the area after the highway development have a slightly more ‘highway-oriented’ profile than the original population, i.e. a marginally higher preference for car accessibility and lower preference for environmental quality. The study sheds light on the importance of accounting for the perceptions of the wider residential population and reveals how the impacts of new highway development differ between and within residential areas

ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma

Leukemia accepted article preview online, 23 March 2017. doi:10.1038/leu.2017.9

How management control systems can facilitate a firm's strategic renewal and creation of financial intelligence

This chapter presents how management control systems and financial intelligence can facilitate a firm’s strategic renewal. Although the strategic accounting literature has recognized the importance of financial intelligence to a firm’s strategic decision making and formulation of strategy, the question of how a management control system (MCS) can help a firm to revamp and reallocate its resources has been overlooked in the prior strategy literature. In response, this chapter presents a conceptual model, which presents how advanced management accounting systems can foster a firm’s strategic renewal in light of the available theoretical foundations (the strategy implementation view, the dynamic capability perspective, and management accounting). This chapter advances managers’ understanding of firm’s renewal practices through the use of an MCS. Practical examples have been used to illustrate how firms renew their business operations in practice.fi=vertaisarvioitu|en=peerReviewed

Does Reviewing Lead to Better Learning and Decision Making? Answers from a Randomized Stock Market Experiment

status: publishe

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies.

Neuromyelitis optica (NMO) is an autoimmune disease of the CNS that is characterized by inflammatory demyelinating lesions in the spinal cord and optic nerve, potentially leading to paralysis and blindness. NMO can usually be distinguished from multiple sclerosis (MS) on the basis of seropositivity for IgG antibodies against the astrocytic water channel aquaporin-4 (AQP4). Differentiation from MS is crucial, because some MS treatments can exacerbate NMO. NMO pathogenesis involves AQP4-IgG antibody binding to astrocytic AQP4, which causes complement-dependent cytotoxicity and secondary inflammation with granulocyte and macrophage infiltration, blood-brain barrier disruption and oligodendrocyte injury. Current NMO treatments include general immunosuppressive agents, B-cell depletion, and plasma exchange. Therapeutic strategies targeting complement proteins, the IL-6 receptor, neutrophils, eosinophils and CD19--all initially developed for other indications--are under clinical evaluation for repurposing for NMO. Therapies in the preclinical phase include AQP4-blocking antibodies and AQP4-IgG enzymatic inactivation. Additional, albeit currently theoretical, treatment options include reduction of AQP4 expression, disruption of AQP4 orthogonal arrays, enhancement of complement inhibitor expression, restoration of the blood-brain barrier, and induction of immune tolerance. Despite the many therapeutic options in NMO, no controlled clinical trials in patients with this condition have been conducted to date