Defect formation processes in structures of magnesium silicates treated by ammonium bifluoride

Authors have studied destruction and defect formation processes of magnesium silicate structures treated by ammonium bifluoride. Obtained amorphous products with uncertain chemical composition were researched by electron microscope and X-ray. High reactivity of these defective structures in solid phase reactions has been identified

Greenhouse gas production in degrading ice-rich permafrost deposits in northeastern Siberia

Permafrost deposits have been a sink for atmospheric carbon for millennia. Thaw-erosional processes, however, can lead to rapid degradation of ice-rich permafrost and the release of substantial amounts of organic carbon (OC). The amount of the OC stored in these deposits and their potential to be microbially decomposed to the greenhouse gases carbon dioxide (CO2) and methane (CH4) depends on climatic and environmental conditions during deposition and the decomposition history before incorporation into the permafrost. Here, we examine potential greenhouse gas production in degrading ice-rich permafrost deposits from three locations in the northeast Siberian Laptev Sea region. The deposits span a period of about 55 kyr from the last glacial period and Holocene interglacial. Samples from all three locations were incubated under aerobic and anaerobic conditions for 134 days at 4 °C. Greenhouse gas production was generally higher in deposits from glacial periods, where 0.2–6.1% of the initially available OC was decomposed to CO2. In contrast, only 0.1–4.0% of initial OC were decomposed in permafrost deposits from the Holocene and the late glacial transition. Within the deposits from the Kargin interstadial period (Marine Isotope Stage 3), local depositional environments, especially soil moisture, also affected the preservation of OC. Sediments deposited under wet conditions contained more labile OC and thus produced more greenhouse gases than sediments deposited under drier conditions. To assess the greenhouse gas production potentials over longer periods, deposits from two locations were incubated for a total of 785 days. However, more than 50% of total CO2 production over 785 days occurred within the first 134 days under aerobic conditions while even 80% were produced over the same period under anaerobic conditions, which emphasizes the non-linearity of the OC decomposition processes. Methanogenesis was generally observed in active layer samples but only sporadically in permafrost samples and was several orders of magnitude smaller than CO2 production

Sensitivity of CSM-CERES-Maize model to soil available water and impact on rainfed maize grown in the Brazilian Cerrado.

The response of maize to variations in soil available water (AW) is a function of the interactions among plant, soil and weather conditions. We studied the sensitivity of a previously calibrated CSM-CERES-Maize model and the response of rainfed maize grain yield to soil AW. The study was conducted for conditions in southeast Brazil. The model was set for weekly sowings, from August to September, for a total of 52 sowing dates. At each sowing date, six scenarios of soil AW using field capacity estimated at -4 kPa, -6 kPa, -10 kPa, -20 kPa, -33 kPa and determined in situ, were used. For each sowing date, the model was also set for rainfall reductions of 10%, 20%, 30%, 40% and 50%. The simulated results showed the sensitivity of the model to soil AW, which in turn affected grain yield of maize among sowing dates. For the highest yielding sowing date, a reduction of 48.3% in average grain yield was simulated with soil AW using FC at -4 kPa and FC at -33 kPa. Additionally, our simulations indicated significant correlation between grain yield and total crop evapotranspiration and between grain yield and maximum leaf area index. Scenarios of low rainfall had little effect on yield with high soil AW. Therefore, our simulations indicate that accurate information on FC is needed for the simulation of maize grown under rainfed conditions. Our simulations also indicate that the best sowing window for maize in southeastern Brazil ranges from Oct 17 to Nov 28

Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials

Background: In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone. However, genotypic changes could be observed in TVR-treated patients who did not achieve an SVR. Methods: Population sequence analysis of the NS3•4A region was performed in patients who did not achieve SVR with TVR-based treatment. Results: Resistant variants were observed after treatment with a telaprevir-based regimen in 12% of treatment-naïve patients (ADVANCE; T12PR arm), 6% of prior relapsers, 24% of prior partial responders, and 51% of prior null responder patients (REALIZE, T12PR48 arms). NS3 protease variants V36M, R155K, and V36M+R155K emerged frequently in patients with genotype 1a and V36A, T54A, and A156S/T in patients with genotype 1b. Lower-level resistance to telaprevir was conferred by V36A/M, T54A/S, R155K/T, and A156S variants; and higher-level resistance to telaprevir was conferred by A156T and V36M+R155K variants. Virologic failure during telaprevir treatment was more common in patients with genotype 1a and in prior PR nonresponder patients and was associated with higher-level telaprevir-resistant variants. Relapse was usually associated with wild-type or lower-level resistant variants. After treatment, viral populations were wild-type with a median time of 10 months for genotype 1a and 3 weeks for genotype 1b patients. Conclusions: A consistent, subtype-dependent resistance profile was observed in patients who did not achieve an SVR with telaprevir-based treatment. The primary role of TVR is to inhibit wild-type virus and variants with lower-levels of resistance to telaprevir. The complementary role of PR is to clear any remaining telaprevir-resistant variants, especially higher-level telaprevir-resistant variants. Resistant variants are detectable in most patients who fail to achieve SVR, but their levels decline over time after treatment

Timing molecular motion and production with a synthetic transcriptional clock

The realization of artificial biochemical reaction networks with unique functionality is one of the main challenges for the development of synthetic biology. Due to the reduced number of components, biochemical circuits constructed in vitro promise to be more amenable to systematic design and quantitative assessment than circuits embedded within living organisms. To make good on that promise, effective methods for composing subsystems into larger systems are needed. Here we used an artificial biochemical oscillator based on in vitro transcription and RNA degradation reactions to drive a variety of “load” processes such as the operation of a DNA-based nanomechanical device (“DNA tweezers”) or the production of a functional RNA molecule (an aptamer for malachite green). We implemented several mechanisms for coupling the load processes to the oscillator circuit and compared them based on how much the load affected the frequency and amplitude of the core oscillator, and how much of the load was effectively driven. Based on heuristic insights and computational modeling, an “insulator circuit” was developed, which strongly reduced the detrimental influence of the load on the oscillator circuit. Understanding how to design effective insulation between biochemical subsystems will be critical for the synthesis of larger and more complex systems

Impact of climate change on maize grown in the brazilian cerrado.

Crops are subject to instabilities of climatic conditions that affect yield. Maize is very sensitive to factors like temperature, solar radiation and rainfall. The objective of this work was to evaluate, using crop growth models, the effects of climate change on maize grain yield produced under rainfed conditions. Two global circulation models, HadGEM2-ES and MIROC5, coupled to the regional model Eta, were used to generate projections of changes in maximum and minimum air temperature, solar radiation and rainfall for conditions in southeastern Brazil. The CSM-CERES-Maize model was then used to evaluate the effect of climate changes on rainfed maize grain yield. For each combination of global and regional circulation models, two greenhouse gas concentration scenarios were used: RCP4.5 and RCP8.5. The combined use of global circulation and crop growth models allowed us to estimate the expected average grain yield of corn as affected by future climate. The simulated results indicated that, even at best sowing dates, considerable reduction in maize grain yield may occur. Our simulated results also indicated that the largest grain yield reductions may occur for future climate scenarios from 2071 to the end of the 21st century

Design, Fabrication, and Experimental Demonstration of Junction Surface Ion Traps

We present the design, fabrication, and experimental implementation of surface ion traps with Y-shaped junctions. The traps are designed to minimize the pseudopotential variations in the junction region at the symmetric intersection of three linear segments. We experimentally demonstrate robust linear and junction shuttling with greater than one million round-trip shuttles without ion loss. By minimizing the direct line of sight between trapped ions and dielectric surfaces, negligible day-to-day and trap-to-trap variations are observed. In addition to high-fidelity single-ion shuttling, multiple-ion chains survive splitting, ion-position swapping, and recombining routines. The development of two-dimensional trapping structures is an important milestone for ion-trap quantum computing and quantum simulations.Comment: 9 pages, 6 figure

Épocas de semeadura de milho em plantios de sequeiro e irrigado em Minas Gerais.

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