105 research outputs found

    Examining The Effect Of Feminist Self-Labeling And Feminist Perspectives On Young Adults\u27 Self-Efficacy

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    The current study utilized data from young adults (undergraduate and graduate students) in order to examine the effect of feminist self-identification (as measured by the Self-Identification as a Feminist Scale) and feminist perspectives (as measured by the Feminist Perspectives Scale—Short Form) on self-efficacy (as measured by General Self-Efficacy Scale total scores). Additionally, this study examined the relationship between demographics (i.e., gender, race) and outcome variables of interest (i.e., feminist self-identification, feminist perspectives, self-efficacy). Participants included 305 individuals who are at least 18 years old and enrolled as undergraduate or graduate students at the University of South Carolina. Multiple regression assessed the relationships among the constructs of feminist self-identification, feminist perspectives, and self-efficacy, while a factorial MANOVA examined differences among demographics (i.e., race, gender) for the variables of interest (i.e., feminist self-identification, feminist perspectives, self-efficacy). Results indicated that feminist behavior (a component of feminist perspectives) is a significant predictor of self-efficacy, and women had higher ratings than men for feminist identification and feminist perspectives. No significant differences existed between White and non-White participants for feminist identification, feminist perspectives, or self-efficacy. A discussion of results, implications for practice, and study limitations are provided

    Occupational Therapy Assistant Students’ Perceptions of using Standardized Patient Encounters as a Replacement for Traditional Level I Fieldwork

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    Standardized patient encounters are being utilized more often in occupational therapy education as a replacement for traditional fieldwork. While there is a growing body of research to support the use of this model in developing student skillsets and confidence, there remains limited information on the topic, and no studies which look at its use with occupational therapy assistant students. Twenty-four occupational therapy assistant students participated in standardized patient encounters which served as a replacement for traditional Level I fieldwork. All students completed an anonymous supplementary course evaluation regarding their experiences. A secondary analysis of the data looked at their perceptions of a standardized patient encounter model for fieldwork and how it did or did not prepare them for future Level II clinicals. Quantitative and qualitative data exposed aspects of these experiences which students found to be most and least effective. Overall, data showed moderate support for use of standardized patient encounters to support student confidence and skills in anticipation of Level II fieldwork. The student perception of these types of experiences is influenced by environmental (e.g., structure) and personal (e.g., student personality) factors. Success requires adequate preparation of all involved parties. Use of standardized patient encounters should be researched further to determine its impact on fieldwork performance evaluation scores and future employment

    The role of ADA inclusive policies in the recruiting of applicants with Autism Spectrum Disorders

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    Autism spectrum disorders (ASD) are a set of neurodevelopmental disorders characterized by deficits in social interactions and interpersonal communication, repetitive behaviors, and narrow focus or interests. The severity of ASD is variable, but the symptoms span the entire lifespan of the individuals with ASD and few effective treatments for these symptoms have been identified. Each year in the United States, there are approximately 50,000 people with ASD who turn 18 years old in the United States (Shattuck et al., 2012). Where most 18 year olds are likely to go out and get a job, the employment prospect of individuals with ASD is not very bright. High school graduates with autism are underemployed when compared to their peers and less employed than high school graduates with other developmental or intellectual disorders (Roux, Shattuck, Rast, & Anderson, 2017). Despite this, some reports suggest that gainful employment can benefit individuals with ASD by providing them with desirable social interactions (Hendricks, 2010), and it is the focus of many service providers for individuals with ASD (Migliore et al., 2014). Like most adults, individuals with ASD benefit from the social status that comes with having a job and the degree of financial independence that employment affords them (Gerhardt & Lainer, 2011). Research has also found that employment is associated with an increase in personal dignity, improved self-esteem, increased adaptive abilities, better mental health, and improved cognitive performance for individuals with ASD (Hurlbutt & Chalmers 2004; Mawhood & Howlin 1999; Stephens et al. 2005). The principle means for addressing the underemployment and unemployment for individuals with ASD is to assist them with gaining the skills and training needed to apply for and get a job. Yet even with these efforts, the employment prospects of individuals with ASD has not significantly improved (Bennett & Dukes 2013; Taylor & Seltzer 2011). The present study will investigate the role that organizational communications about hiring and employment policies regarding the Americans with Disabilities Act may have on the potential recruitment of those with ASD as well as the degree to which potential applicants who do not have ASD view these inclusive statements as favorable

    #TransformFFA: An Analysis of Social Media Content During the 2016 National FFA Convention

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    The proliferation of social media has the ability to considerably impact stakeholders’ perspective of an organization’s brand. Due to this relationship, social media analysis is crucial to executing informed brand communication strategies. In October 2016, the brand communication strategies of the National FFA Organization were focused on promoting the 89th National FFA Convention. A large portion of these efforts and resources were dedicated towards the utilization of social media. This study was designed as a content analysis of the National FFA Organization’s social media presence during the dates of the convention. The goal was to identify the prominent themes of communication and the alignment of these themes with the organizational brand. Conversations on Facebook, Twitter, Instagram, and Snapchat yielded a total of 344 posts for evaluation. The results indicated the presence of seven predominate themes: recognition, connectivity, appreciation, spirit, service, influence, and support. The researchers suggest opportunities exist for closer alignment between published social media content and the defined organizational and event brands. Specific attention should be placed on event-specific theme promotion. Renewed efforts to increase interactivity will allow for stakeholders to take part in the brand co-building process. It should be ensured that all communications are an accurate reflection of the brand’s image, connections, and reputation

    Evaluating the successful implementation of evidence into practice using the PARiHS framework : theoretical and practical challenges

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    Background The PARiHS framework (Promoting Action on Research Implementation in Health Services) has proved to be a useful practical and conceptual heuristic for many researchers and practitioners in framing their research or knowledge translation endeavours. However, as a conceptual framework it still remains untested and therefore its contribution to the overall development and testing of theory in the field of implementation science is largely unquantified. Discussion This being the case, the paper provides an integrated summary of our conceptual and theoretical thinking so far and introduces a typology (derived from social policy analysis) used to distinguish between the terms conceptual framework, theory and model – important definitional and conceptual issues in trying to refine theoretical and methodological approaches to knowledge translation. Secondly, the paper describes the next phase of our work, in particular concentrating on the conceptual thinking and mapping that has led to the generation of the hypothesis that the PARiHS framework is best utilised as a two-stage process: as a preliminary (diagnostic and evaluative) measure of the elements and sub-elements of evidence (E) and context (C), and then using the aggregated data from these measures to determine the most appropriate facilitation method. The exact nature of the intervention is thus determined by the specific actors in the specific context at a specific time and place. In the process of refining this next phase of our work, we have had to consider the wider issues around the use of theories to inform and shape our research activity; the ongoing challenges of developing robust and sensitive measures; facilitation as an intervention for getting research into practice; and finally to note how the current debates around evidence into practice are adopting wider notions that fit innovations more generally. Summary The paper concludes by suggesting that the future direction of the work on the PARiHS framework is to develop a two-stage diagnostic and evaluative approach, where the intervention is shaped and moulded by the information gathered about the specific situation and from participating stakeholders. In order to expedite the generation of new evidence and testing of emerging theories, we suggest the formation of an international research implementation science collaborative that can systematically collect and analyse experiences of using and testing the PARiHS framework and similar conceptual and theoretical approaches. We also recommend further refinement of the definitions around conceptual framework, theory, and model, suggesting a wider discussion that embraces multiple epistemological and ontological perspectives

    Variability in a dominant block to SIV early reverse transcription in rhesus monkey cells predicts in vivo viral replication and time to death

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    While it has long been appreciated that there is considerable variability in host containment of HIV/SIV replication, the determinants of that variability are not fully understood. Previous studies demonstrated that the degree of permissivity of a macaque's peripheral blood mononuclear cells (PBMC) for infection with simian immunodeficiency virus (SIV) in vitro predicted that animal's peak plasma virus RNA levels following SIV infection in vivo. The present study was conducted to define the mechanisms underlying the variable intrinsic susceptibility of rhesus monkey PBMC to SIVsmE660 infection. In a cohort of 15 unrelated Indian-origin rhesus monkeys, infectability of PBMC of individual animals with SIVsmE660, as defined by tissue culture infectious dose (TCID50), varied by more than 3 logs and was a stable phenotype over time. Susceptibility of a monkey's PBMC to wild type SIVsmE660 infection correlated with the susceptibility of that monkey's PBMC to infection with VSV-G pseudotyped SIVsm543-GFP. Moreover, the permissivity of an individual monkey's PBMC for infection with this construct correlated with the permissivity of a B-lymphoblastoid cell line (B-LCL) generated from PBMC of the same animal. We found that the degree of intrinsic resistance of monkey B-LCL correlated with the copy number of early reverse transcription (ERT) SIV DNA. The resistance of monkey B-LCL to SIVsmE660 replication could be abrogated by preincubation of cells with the SIV virus-like particles (VLPs) and SIV resistance phenotype could be transferred to a SIV susceptible B-LCL through cell fusion. Finally, we observed a positive correlation between susceptibility of monkey B-LCL to SIV infection with a VSV-G pseudotyped SIV-GFP construct in vitro and both the peak plasma virus RNA levels in vivo and time to death following wild type SIV infection. These findings suggest that a dominant early RT restricting factor that can be saturated by SIV capsid may contribute to the variable resistance to SIV infection in rhesus monkey B-LCL and that this differential intrinsic susceptibility contributes to the clinical outcome of an SIV infection

    TRIM5α Modulates Immunodeficiency Virus Control in Rhesus Monkeys

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    The cytoplasmic TRIM5α proteins of certain mammalian lineages efficiently recognize the incoming capsids of particular retroviruses and potently restrict infection in a species-specific manner. Successful retroviruses have evolved capsids that are less efficiently recognized by the TRIM5α proteins of the natural hosts. To address whether TRIM5α contributes to the outcome of retroviral infection in a susceptible host species, we investigated the impact of TRIM5 polymorphisms in rhesus monkeys on the course of a simian immunodeficiency virus (SIV) infection. Full-length TRIM5α cDNAs were derived from each of 79 outbred monkeys and sequenced. Associations were explored between the expression of particular TRIM5 alleles and both the permissiveness of cells to SIV infection in vitro and clinical sequelae of SIV infection in vivo. Natural variation in the TRIM5α B30.2(SPRY) domain influenced the efficiency of SIVmac capsid binding and the in vitro susceptibility of cells from the monkeys to SIVmac infection. We also show the importance in vivo of the interaction of SIVmac with different allelic forms of TRIM5, demonstrating that particular alleles are associated with as much as 1.3 median log difference in set-point viral loads in SIVmac-infected rhesus monkeys. Moreover, these allelic forms of TRIM5 were associated with the extent of loss of central memory (CM) CD4+ T cells and the rate of progression to AIDS in the infected monkeys. These findings demonstrate a central role for TRIM5α in limiting the replication of an immunodeficiency virus infection in a primate host

    Pheromone-sensing neurons regulate peripheral lipid metabolism in <i>Caenorhabditis elegans</i>

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    It is now established that the central nervous system plays an important role in regulating whole body metabolism and energy balance. However, the extent to which sensory systems relay environmental information to modulate metabolic events in peripheral tissues has remained poorly understood. In addition, it has been challenging to map the molecular mechanisms underlying discrete sensory modalities with respect to their role in lipid metabolism. In previous work our lab has identified instructive roles for serotonin signaling as a surrogate for food availability, as well as oxygen sensing, in the control of whole body metabolism. In this study, we now identify a role for a pair of pheromone-sensing neurons in regulating fat metabolism in C. elegans, which has emerged as a tractable and highly informative model to study the neurobiology of metabolism. A genetic screen revealed that GPA-3, a member of the Gα family of G proteins, regulates body fat content in the intestine, the major metabolic organ for C. elegans. Genetic and reconstitution studies revealed that the potent body fat phenotype of gpa-3 null mutants is controlled from a pair of neurons called ADL(L/R). We show that cAMP functions as the second messenger in the ADL neurons, and regulates body fat stores via the neurotransmitter acetylcholine, from downstream neurons. We find that the pheromone ascr#3, which is detected by the ADL neurons, regulates body fat stores in a GPA-3-dependent manner. We define here a third sensory modality, pheromone sensing, as a major regulator of body fat metabolism. The pheromone ascr#3 is an indicator of population density, thus we hypothesize that pheromone sensing provides a salient 'denominator' to evaluate the amount of food available within a population and to accordingly adjust metabolic rate and body fat levels

    Bioinorganic Chemistry of Alzheimer’s Disease

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    The Habitable Exoplanet Observatory (HabEx) Mission Concept Study Final Report

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    The Habitable Exoplanet Observatory, or HabEx, has been designed to be the Great Observatory of the 2030s. For the first time in human history, technologies have matured sufficiently to enable an affordable space-based telescope mission capable of discovering and characterizing Earthlike planets orbiting nearby bright sunlike stars in order to search for signs of habitability and biosignatures. Such a mission can also be equipped with instrumentation that will enable broad and exciting general astrophysics and planetary science not possible from current or planned facilities. HabEx is a space telescope with unique imaging and multi-object spectroscopic capabilities at wavelengths ranging from ultraviolet (UV) to near-IR. These capabilities allow for a broad suite of compelling science that cuts across the entire NASA astrophysics portfolio. HabEx has three primary science goals: (1) Seek out nearby worlds and explore their habitability; (2) Map out nearby planetary systems and understand the diversity of the worlds they contain; (3) Enable new explorations of astrophysical systems from our own solar system to external galaxies by extending our reach in the UV through near-IR. This Great Observatory science will be selected through a competed GO program, and will account for about 50% of the HabEx primary mission. The preferred HabEx architecture is a 4m, monolithic, off-axis telescope that is diffraction-limited at 0.4 microns and is in an L2 orbit. HabEx employs two starlight suppression systems: a coronagraph and a starshade, each with their own dedicated instrument
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