Low Carbon Shipping, Transport & Market Incentive Programs

The carbon labeling project presents methods to promote biodiesel use, disseminate information on the potential carbon efficiency of biofuels and promote the concept of carbon labeling. This guide is aimed at policy makers and interested industry groups. It aims to evaluate the suitability of the US EPA (Environmental Protection Agency) Smart Way Transport Partnership as a model for the EU to promote more efficiency and low carbon shipping of goods to market. It includes: a thorough description of the US EPA scheme and its objectives; carbon labeling initiatives in the UK (independent and national); a review of the strengths and weaknesses of the US EPA scheme with regards to its suitability for EU transport policy; the different EU transport system and pilot programmes; and suggestions for freight and multi-sector low carbon transport programmes in the EU. This useful guide enables decision makers to develop a road map on how best to provide incentives for implementing a low carbon shipping program in Europe

Semi-parametric Expected Shortfall Forecasting

Intra-day sources of data have proven effective for dynamic volatility and tail risk estimation. Expected shortfall is a tail risk measure, that is now recommended by the Basel Committee, involving a conditional expectation that can be semi-parametrically estimated via an asymmetric sum of squares function. The conditional autoregressive expectile class of model, used to indirectly model expected shortfall, is generalised to incorporate information on the intra-day range. An asymmetric Gaussian density model error formulation allows a likelihood to be developed that leads to semiparametric estimation and forecasts of expectiles, and subsequently of expected shortfall. Adaptive Markov chain Monte Carlo sampling schemes are employed for estimation, while their performance is assessed via a simulation study. The proposed models compare favourably with a large range of competitors in an empirical study forecasting seven financial return series over a ten year period

Resistin-Like Molecule-β Inhibits SGLT-1 Activity and Enhances GLUT2-Dependent Jejunal Glucose Transport

International audienceOBJECTIVE: An increased expression of RELM-beta (resistin-like molecule-beta), a gut-derived hormone, is observed in animal models of insulin resistance/obesity and intestinal inflammation. Intestinal sugar absorption is modulated by dietary environment and hormones/cytokines. The aim of this study was to investigate the effect of RELM-beta on intestinal glucose absorption. RESEARCH DESIGN AND METHODS: Oral glucose tolerance test was performed in mice and rats in the presence and the absence of RELM-beta. The RELM-beta action on glucose transport in rat jejunal sacs, everted rings, and mucosal strips was explored as well as downstream kinases modulating SGLT-1 and GLUT2 glucose transporters. RESULTS: Oral glucose tolerance test carried out in rodents showed that oral administration of RELM-beta increased glycemia. Studies in rat jejunal tissue indicated that mucosal RELM-beta promoted absorption of glucose from the gut lumen. RELM-beta had no effect on paracellular mannitol transport, suggesting a transporter-mediated transcellular mechanism. In studies with jejunal mucosa mounted in Ussing chamber, luminal RELM-beta inhibited SGLT-1 activity in line with a diminished SGLT-1 abundance in brush border membranes (BBMs). Further, the potentiating effect of RELM-beta on jejunal glucose uptake was associated with an increased abundance of GLUT2 at BBMs. The effects of RELM-beta were associated with an increased amount of protein kinase C betaII in BBMs and an increased phosphorylation of AMP-activated protein kinase (AMPK). CONCLUSIONS: The regulation of SGLT-1 and GLUT2 by RELM-beta expands the role of gut hormones in short-term AMPK/protein kinase C mediated control of energy balance

Results from the European carbon labelling initiative CO2 Star

Today, passenger cars alone are responsible for around 12% of European CO 2 emissions. An opportunity to reduce CO 2 emissions in transport is provided by the use of biofuels with beneficial life cycle CO 2 emissions. The Carbon Labelling project (Project No. EIE/06/015) promotes the use of biofuels by implementing different labelling initiatives in Europe and applying the developed carbon label "CO 2Star" to biodiesel, efficient lubricants and biofuel based freight services. In a first step a supportable methodology for the quantification of carbon life cycle reductions was identified in co-operation with recent and on-going activities and methodologies by European and worldwide expert groups such as SenterNovem (NL), ifeu Institute (DE) and Imperial College (UK). In a second step the Carbon Labelling initiative actively promoted this carbon reduction to consumers. Finally, a consumer survey was conducted in order to assess the success of this initiative and the acceptance of GHG labels. This paper gives an overview about the current discussion on carbon reductions in the transport sector, different GHG calculation methodologies, and about the results of the 'Carbon Labelling' project which is supported by the Intelligent Energy Europe Programme.peer-reviewe

Spatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas

Peer reviewe

Exploring immunological mechanisms in cow’s milk allergy

Koemelkallergie is de meest voorkomende allergische aandoening op de zuigelingenleeftijd. Rond de leeftijd van drie jaar zijn de meeste kinderen over hun allergie heen gegroeid, maar een minderheid blijft allergisch. Waarom is vooralsnog onbekend. Anders van Thuijl onderzocht immunologische mechanismen die hierbij een rol spelen. Hij toont aan dat de witte bloedcellen (T-cellen) van kinderen die gedurende de kinderleeftijd allergisch voor koemelkeiwit blijven op de zuigelingenleeftijd significant meer eiwitten (Th2-gemedieerde cytokines, die allergische reacties aansturen) produceren dan kinderen die op jonge leeftijd over hun allergie heen groeien. Deze bevinding kan clinici helpen de zuigeling met een verhoogd risico op persisterende koemelkallergie te identificeren