Empowering Children to Learn: An Exploratory Study Using a Philosophical Listening Tool (the Little Box of Big Questions 2)

A key function of educational psychologists is to promote empowering and cultivating learning environments that prepare children and young people for the twenty-first century. This study explores how children may be empowered to learn through the clarification of their daily lived experiences. Learning experiences are examined from the perspective of the children themselves, with a particular emphasis on metaphysical concepts. A listening tool was used to gather data: in-depth stories, experiences, motivations and beliefs about individual learning. Thematic analysis was applied to interviews, further promoting the ‘voice of the child’ and illuminating how children think about their own learning. Autonomy, experience and purpose are examined in the context of how children learn. This research aims to contribute towards the growing body of knowledge about how children learn. The findings may help to inform the work of educational psychologists and enhance the educational experiences of children and young people

On the structure of line-driven winds near black holes

A general physical mechanism of the formation of line-driven winds at the vicinity of strong gravitational field sources is investigated in the frame of General Relativity. We argue that gravitational redshifting should be taken into account to model such outflows. The generalization of the Sobolev approximation in the frame of General Relativity is presented. We consider all processes in the metric of a nonrotating (Schwarzschild) black hole. The radiation force that is due to absorbtion of the radiation flux in lines is derived. It is demonstrated that if gravitational redshifting is taken into account, the radiation force becomes a function of the local velocity gradient (as in the standard line-driven wind theory) and the gradient of $g_{00}$. We derive a general relativistic equation of motion describing such flow. A solution of the equation of motion is obtained and confronted with that obtained from the Castor, Abbott & Klein (CAK) theory. It is shown that the proposed mechanism could have an important contribution to the formation of line-driven outflows from compact objects.Comment: 20 pages, submitted to Ap

Transcriptome of the dead: characterisation of immune genes and marker development from necropsy samples in a free-ranging marine mammal

Background Transcriptomes are powerful resources, providing a window on the expressed portion of the genome that can be generated rapidly and at low cost for virtually any organism. However, because many genes have tissue-specific expression patterns, developing a complete transcriptome usually requires a 'discovery pool' of individuals to be sacrificed in order to harvest mRNA from as many different types of tissue as possible. This hinders transcriptome development in large, charismatic and endangered species, many of which stand the most to gain from such approaches. To circumvent this problem in a model pinniped species, we 454 sequenced cDNA from testis, heart, spleen, intestine, kidney and lung tissues obtained from nine adult male Antarctic fur seals (Arctocephalus gazella) that died of natural causes at Bird Island, South Georgia. Results After applying stringent quality control criteria based on length and annotation, we obtained 12,397 contigs which, in combination with 454 data previously obtained from skin, gave a total of 23,096 unique contigs. Homology was found to 77.0% of dog (Canis lupus familiaris) transcripts, suggesting that the combined assembly represents a substantial proportion of this species' transcriptome. Moreover, only 0.5% of transcripts revealed sequence similarity to bacteria, implying minimal contamination, and the percentage of transcripts involved in cell death was low at 2.6%. Transcripts with immune-related annotations were almost five-fold enriched relative to skin and represented 13.2% of all spleen-specific contigs. By reference to the dog, we also identified transcripts revealing homology to five class I, ten class II and three class III genes of the Major Histocompatibility Complex and derived the putative genomic distribution of 17,121 contigs, 2,119 in silico mined microsatellites and 9,382 single nucleotide polymorphisms. Conclusions Our findings suggest that transcriptome development based on samples collected post mortem may greatly facilitate genomic studies, not only of marine mammals but also more generally of species that are of conservation concern

Hollowgraphy Driven Holography: Black Hole with Vanishing Volume Interior

Hawking-Bekenstein entropy formula seems to tell us that no quantum degrees of freedom can reside in the interior of a black hole. We suggest that this is a consequence of the fact that the volume of any interior sphere of finite surface area simply vanishes. Obviously, this is not the case in general relativity. However, we show that such a phenomenon does occur in various gravitational theories which admit a spontaneously induced general relativity. In such theories, due to a phase transition (one parameter family degenerates) which takes place precisely at the would have been horizon, the recovered exterior Schwarzschild solution connects, by means of a self-similar transition profile, with a novel 'hollow' interior exhibiting a vanishing spatial volume and a locally varying Newton constant. This constitutes the so-called 'hollowgraphy' driven holography.Comment: Honorable Mention Essay - Gravity Research Foundation (2010

Previous reproductive history and post-natal family planning among HIV-infected women in Ukraine

BACKGROUND: Ukraine has the highest antenatal HIV prevalence in Europe. The national prevention of mother-to-child transmission (MTCT) programme has reduced the MTCT rate, but less attention has been given to the prevention of unintended pregnancy among HIV-positive women. Our objectives were to describe the reproductive health, condom use and family planning (FP) practices of HIV-positive childbearing Ukrainian women and to identify factors associated with different methods of post-natal contraception. METHODS: HIV-infected childbearing women, diagnosed before or during pregnancy, were enrolled prospectively in a post-natal cohort study in four regional HIV/AIDS centres in Ukraine from December 2007. Logistic regression models were used to identify factors associated with post-natal FP practices. RESULTS: Data were available for 371 women enrolled by March 2009; 82% (n = 303) were married or cohabiting, 27% (97 of 363) reported a current HIV-negative sexual partner and 69% were diagnosed with HIV during their most recent pregnancy. Overall, 21% (75 of 349) of women were not using contraception post-natally (of whom 80% reported no current sexual activity), 50% (174 of 349) used condoms, 20% (74 of 349) relied solely/partially on coitus interruptus and 4% used hormonal methods or intrauterine device. Among married/cohabiting women, consistent use of condoms in the previous pregnancy [AOR 1.96 (95%CI 1.06–3.62)], having an HIV-positive partner [AOR 0.42 (0.20–0.87)], current sexual activity [AOR 4.53 (1.19–17.3)] and study site were significantly associated with post-natal condom use; 16% of those with HIV-negative partners did not use condoms. Risk factors for non-use of FP were lack of affordability [AOR 6.34 (1.73–23.2)] and inconsistent use of condoms in the previous pregnancy [AOR 7.25 (1.41–37.2)]. CONCLUSIONS: More than 40% of HIV-positive women in this population are at risk of unintended pregnancy and the one in six women in HIV-discordant couples not using barrier methods risk transmitting HIV to their partners. Our study results are limited by the observational nature of the data and the potential for both measured and unmeasured confounding

Progress in prevention of mother-to-child transmission of HIV infection in Ukraine: results from a birth cohort study

Background: Ukraine was the epicentre of the HIV epidemic in Eastern Europe, which has the most rapidly accelerating HIV epidemic world-wide today; national HIV prevalence is currently estimated at 1.6%. Our objective was to evaluate the uptake and effectiveness of interventions for prevention of mother-to-child transmission (PMTCT) over an eight year period within operational settings in Ukraine, within the context of an ongoing birth cohort study.Methods: The European Collaborative Study (ECS) is an ongoing birth cohort study in which HIV-infected pregnant women identified before or during pregnancy or at delivery were enrolled and their infants prospectively followed. Three centres in Ukraine started enrolling in 2000, with a further three joining in September 2006.Results: Of the 3356 women enrolled, 21% (689) reported current or past injecting drug use (IDU). Most women were diagnosed antenatally and of those, the proportion diagnosed in the first/second trimester increased from 47% in 2000/01 (83/178) to 73% (776/1060) in 2006/07 (p < 0.001); intrapartum diagnosis was associated with IDU (Adjusted odds ratio 4.38; 95% CI 3.19-6.02). The percentage of women not receiving any antiretroviral prophylaxis declined from 18% (36/205) in 2001 to 7% in 2007 (61/843) p < 0.001). Use of sdNVP alone substantially declined after 2003, with a concomitant increase in zidovudine prophylaxis. Median antenatal zidovudine prophylaxis duration increased from 24 to 72 days between 2000 and 2007. Elective caesarean section (CS) rates were relatively stable over time and 34% overall. Mother-to-child transmission (MTCT) rates decreased from 15.2% in 2001 (95% CI 10.2-21.4) to 7.0% in 2006 (95% CI 2.6-14.6). In adjusted analysis, MTCT risk was reduced by 43% with elective CS versus vaginal delivery and by 75% with zidovudine versus no prophylaxis.Conclusion: There have been substantial improvements in use of PMTCT interventions in Ukraine, including earlier diagnosis of HIV-infected pregnant women and increasing coverage with antiretroviral prophylaxis and the initial MTCT rate has more than halved. Future research should focus on hard-to-reach populations such as IDU and on missed opportunities for further reducing the MTCT rate

Non-monotonic orbital velocity profiles around rapidly rotating Kerr-(anti-)de Sitter black holes

It has been recently demonstrated that the orbital velocity profile around Kerr black holes in the equatorial plane as observed in the locally non-rotating frame exhibits a non-monotonic radial behaviour. We show here that this unexpected minimum-maximum feature of the orbital velocity remains if the Kerr vacuum is generalized to the Kerr-de Sitter or Kerr-anti-de Sitter metric. This is a new general relativity effect in Kerr spacetimes with non-vanishing cosmological constant. Assuming that the profile of the orbital velocity is known, this effect constrains the spacetime parameters.Comment: 9 pages, 4 figures, accepted for Class. Quant. Gra

The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken

The replacement histone H2A.Z is variously reported as being linked to gene expression and preventing the spread of heterochromatin in yeast, or concentrated at heterochromatin in mammals. To resolve this apparent dichotomy, affinity-purified antibodies against the N-terminal region of H2A.Z, in both a triacetylatedandnon- acetylatedstate, areusedin native chromatin immmuno-precipitation experiments with mononucleosomes from three chicken cell types. The hyperacetylated species concentrates at the 50 end of active genes, both tissue specific and housekeeping but is absent from inactive genes, while the unacetylated form is absent from both active and inactive genes. A concentration of H2A.Z is also found at insulators under circumstances implying a link to barrier activity but not to enhancer blocking. Although acetylated H2A.Z is widespread throughout the interphase genome, at mitosis its acetylation is erased, the unmodified form remaining. Thus, although H2A.Z may operate as an epigenetic marker for active genes, its N-terminal acetylation does not

A stochastic template placement algorithm for gravitational wave data analysis

This paper presents an algorithm for constructing matched-filter template banks in an arbitrary parameter space. The method places templates at random, then removes those which are "too close" together. The properties and optimality of stochastic template banks generated in this manner are investigated for some simple models. The effectiveness of these template banks for gravitational wave searches for binary inspiral waveforms is also examined. The properties of a stochastic template bank are then compared to the deterministically placed template banks that are currently used in gravitational wave data analysis.Comment: 14 pages, 11 figure

The Pulsed Neutron Beam EDM Experiment

We report on the Beam EDM experiment, which aims to employ a pulsed cold neutron beam to search for an electric dipole moment instead of the established use of storable ultracold neutrons. We present a brief overview of the basic measurement concept and the current status of our proof-of-principle Ramsey apparatus