9 research outputs found

    Physician innovators

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    Making medicolegal framework useful

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    Making medicolegal framework useful

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    To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Downloa

    Chasing ghosts : catching ESP hacking in 3d multiplayer games

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    Cheating in online games is a current and ongoing problem, a subgenre of cheating Extra Sensory Perception is a method where a cheater overlays their opponent’s location, health, and items providing them precognition of every encounter with other players. Statistical and behavioral analysis can not be used conclusively to differentiate ESP cheating from normal gameplay. Drawing out cheating behavior using a games environment, without disturbing normal gameplay, contrasting the cheater from honest players becomes an attractive solution. Can cheaters be drawn out using a games environment?, Can it be done so it does not affect normal gameplay?. Using reverse engineering techniques on the server’s executables and function libraries working around limited access to the server’s source code. Implementing our ideas by modifying a server running the videogame Rust utilizing Oxide plugin framework as a primary interface attempting to answer these questions. We build upon the central concept of getting measurable reactions from ESP cheaters different enough from normal gameplay behavior that it becomes viable to enforce the game’s rules based on the difference. Within this project, we detail three distinct attempts to answer these questions with varying degrees of success. Our methods show some promise but the central research questions remain unanswered

    Large-scale whole-genome sequencing of the Icelandic population.

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    To access publisher's full text version of this article click on the hyperlink at the bottom of the pageHere we describe the insights gained from sequencing the whole genomes of 2,636 Icelanders to a median depth of 20×. We found 20 million SNPs and 1.5 million insertions-deletions (indels). We describe the density and frequency spectra of sequence variants in relation to their functional annotation, gene position, pathway and conservation score. We demonstrate an excess of homozygosity and rare protein-coding variants in Iceland. We imputed these variants into 104,220 individuals down to a minor allele frequency of 0.1% and found a recessive frameshift mutation in MYL4 that causes early-onset atrial fibrillation, several mutations in ABCB4 that increase risk of liver diseases and an intronic variant in GNAS associating with increased thyroid-stimulating hormone levels when maternally inherited. These data provide a study design that can be used to determine how variation in the sequence of the human genome gives rise to human diversity

    Large-scale whole-genome sequencing of the Icelandic population

    No full text
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