Hemispheric Asymmetries in Cortical Thickness

Using magnetic resonance imaging and computational cortical pattern matching methods, we analyzed hemispheric differences in regional gray matter thickness across the lateral and medial cortices in young, healthy adults (n = 60). In addition, we investigated the influence of gender on the degree of thickness asymmetry. Results revealed global and regionally specific differences between the two hemispheres, with generally thicker cortex in the left hemisphere. Regions with significant leftward asymmetry were identified in the precentral gyrus, middle frontal, anterior temporal and superior parietal lobes, while rightward asymmetry was prominent in the inferior posterior temporal lobe and inferior frontal lobe. On the medial surface, significant rightward asymmetries were observed in posterior regions, while significant leftward asymmetries were evident from the vicinity of the paracentral gyrus extending anteriorly. Asymmetry profiles were similar in both sexes, but hemispheric differences appeared slightly pronounced in males compared with females, albeit a few regions also indicated greater asymmetry in females compared with males. Hemispheric differences in the thickness of the cortex might be related to hemisphere-specific functional specializations that are possibly related to behavioral asymmetrie

A Neural Networks Committee for the Contextual Bandit Problem

This paper presents a new contextual bandit algorithm, NeuralBandit, which does not need hypothesis on stationarity of contexts and rewards. Several neural networks are trained to modelize the value of rewards knowing the context. Two variants, based on multi-experts approach, are proposed to choose online the parameters of multi-layer perceptrons. The proposed algorithms are successfully tested on a large dataset with and without stationarity of rewards.Comment: 21st International Conference on Neural Information Processin

Recent Developments of NEMO: Detection of Solar Eruptions Characteristics

The recent developments in space instrumentation for solar observations and telemetry have caused the necessity of advanced pattern recognition tools for the different classes of solar events. The Extreme ultraviolet Imaging Telescope (EIT) of solar corona on-board SOHO spacecraft has uncovered a new class of eruptive events which are often identified as signatures of Coronal Mass Ejection (CME) initiations on solar disk. It is evident that a crucial task is the development of an automatic detection tool of CMEs precursors. The Novel EIT wave Machine Observing (NEMO) (http://sidc.be/nemo) code is an operational tool that detects automatically solar eruptions using EIT image sequences. NEMO applies techniques based on the general statistical properties of the underlying physical mechanisms of eruptive events on the solar disc. In this work, the most recent updates of NEMO code - that have resulted to the increase of the recognition efficiency of solar eruptions linked to CMEs - are presented. These updates provide calculations of the surface of the dimming region, implement novel clustering technique for the dimmings and set new criteria to flag the eruptive dimmings based on their complex characteristics. The efficiency of NEMO has been increased significantly resulting to the extraction of dimmings observed near the solar limb and to the detection of small-scale events as well. As a consequence, the detection efficiency of CMEs precursors and the forecasts of CMEs have been drastically improved. Furthermore, the catalogues of solar eruptive events that can be constructed by NEMO may include larger number of physical parameters associated to the dimming regions.Comment: 12 Pages, 5 figures, submitted to Solar Physic

Relationships Between Sulcal Asymmetries and Corpus Callosum Size: Gender and Handedness Effects

Magnetic resonance imaging was used to establish the presence and nature of relationships between sulcal asymmetries and mid-sagittal callosal size in neurologically intact subjects, and to determine the influences of sex and handedness. Against a background of long-standing disputes, effects of gender and handedness on callosal size, shape, and variability were additionally examined. Both positive and negative correlations between sulcal asymmetry and callosal size were observed, with effects influenced by sex and handedness. The direction of relationships, however, were dependent on the regional asymmetry measured and on whether real or absolute values were used to quantify sulcal asymmetries. Callosal measurements showed no significant effects of sex or handedness, although subtle differences in callosal shape were observed in anterior and posterior regions between males and females and surface variability was increased in males. Individual variations in callosal size appear to outrange any detectable divergences in size between groups. Relationships between sulcal asymmetries and callosal size, however, are influenced by both sex and handedness. Whether magnitudes of asymmetry are related to increases or decreases in callosal size appears dependent on the chosen indicators of asymmetry. It is an oversimplification, therefore, to assume a single relationship exists between cerebral asymmetries and callosal connection

Space-variant filtering for correction of wavefront curvature effects in spotlight-mode SAR imagery formed via polar formatting

Wavefront curvature defocus effects can occur in spotlight-mode SAR imagery when reconstructed via the well-known polar formatting algorithm (PFA) under certain scenarios that include imaging at close range, use of very low center frequency, and/or imaging of very large scenes. The range migration algorithm (RMA), also known as seismic migration, was developed to accommodate these wavefront curvature effects. However, the along-track upsampling of the phase history data required of the original version of range migration can in certain instances represent a major computational burden. A more recent version of migration processing, the Frequency Domain Replication and Downsampling (FReD) algorithm, obviates the need to upsample, and is accordingly more efficient. In this paper the authors demonstrate that the combination of traditional polar formatting with appropriate space-variant post-filtering for refocus can be as efficient or even more efficient than FReD under some imaging conditions, as demonstrated by the computer-simulated results in this paper. The post-filter can be pre-calculated from a theoretical derivation of the curvature effect. The conclusion is that the new polar formatting with post filtering algorithm (PF2) should be considered as a viable candidate for a spotlight-mode image formation processor when curvature effects are present

Studies on Monitoring and Tracking Genetic Resources: An Executive Summary

The principles underlying fair and equitable sharing of benefits derived from the utilization of genetic resources are set out in Article 15 of the UN Convention on Biological Diversity, which stipulate that access to genetic resources is subject to the prior informed consent of the country where such resources are located and to mutually agreed terms regarding the sharing of benefits that could be derived from such access. One issue of particular concern for provider countries is how to monitor and track genetic resources once they have left the provider country and enter into use in a variety of forms. This report was commissioned to provide a detailed review of advances in DNA sequencing technologies, as those methods apply to identification of genetic resources, and the use of globally unique persistent identifiers for persistently linking to data and other forms of digital documentation that is linked to individual genetic resources. While the report was written for an audience with a mixture of technical, legal, and policy backgrounds it is relevant to the genomics community as it is an example of downstream application of genomics information

Metabolite changes in blood predict the onset of tuberculosis

Immunogenetics and cellular immunology of bacterial infectious disease

The effect of preconditioning on production and antibiotic use in a South African beef feedlot

CONTEXT : There is pressure on production veterinarians to reduce the use of antibiotics in intensive beef production systems. AIMS : The present study investigated whether preconditioning – the process whereby weaned calves destined for the feedlot are prepared over a period of time – reduced antibiotic treatment events, and improved health and production of calves in a South African feedlot. METHODS : Preconditioned calves (n = 301) and control calves (n = 332) were sourced from the same origin on two occasions, and arrived at the feedlot on the same day. Bovine respiratory disease (BRD) was defined as the ‘pulling’ of clinically sick calves from feedlot pens, followed by the standard protocol for treatment of BRD (including antibiotic treatment). Outcome variables related to health were BRD overall incidence (pulling), BRD re-pulling and lung lesion scores. Production outcome variables measured were carcass weight, carcass average daily gain (ADG) and days on feed (DOF). Initial carcass weight was estimated from shrunk liveweight in order to estimate the effect of preconditioning on carcass gain, the most economically relevant outcome. Statistical analyses were done using multiple linear, logistic and Cox regression. Predictor variables were preconditioning vs control, gender, starting weight, DOF, pulling for BRD and carcass ADG. KEY RESULTS : A lower proportion of preconditioned calves were pulled and a lower proportion of pulled calves were re-pulled for BRD compared with control calves (8 vs 17% and 8 vs 16%, respectively, P < 0.01). A higher proportion of preconditioned calves compared with control calves were market ready at 90 DOF (89 vs 67%, P < 0.01). In the multivariable models preconditioning was associated with a 200 g/d increase in carcass growth rate (P < 0.01) and with a 17.7 kg increase in overall carcass gain (P < 0.01) after adjusting for gender and DOF. CONCLUSIONS : Preconditioning reduced the incidence and severity of BRD and feedlot standing time and improved production of calves in South African feedlots. IMPLICATIONS : Preconditioning has the potential to add value to the beef feedlot by reducing the formation of antimicrobial resistance while improving the profitability of the feedlot.Red Meat Research and Development South Africa (RMRD-SA)http://www.publish.csiro.au/anhj2021Production Animal Studie

3D Coronal Density Reconstruction and Retrieving the Magnetic Field Structure during Solar Minimum

Measurement of the coronal magnetic field is a crucial ingredient in understanding the nature of solar coronal phenomena at all scales. We employed STEREO/COR1 data obtained during a deep minimum of solar activity in February 2008 (Carrington rotation CR 2066) to retrieve and analyze the three-dimensional (3D) coronal electron density in the range of heights from 1.5 to 4 Rsun using a tomography method. With this, we qualitatively deduced structures of the coronal magnetic field. The 3D electron density analysis is complemented by the 3D STEREO/EUVI emissivity in the 195 A band obtained by tomography for the same CR. A global 3D MHD model of the solar corona was used to relate the reconstructed 3D density and emissivity to open/closed magnetic field structures. We show that the density maximum locations can serve as an indicator of current sheet position, while the locations of the density gradient maximum can be a reliable indicator of coronal hole boundaries. We find that the magnetic field configuration during CR 2066 has a tendency to become radially open at heliocentric distances greater than 2.5 Rsun. We also find that the potential field model with a fixed source surface (PFSS) is inconsistent with the boundaries between the regions with open and closed magnetic field structures. This indicates that the assumption of the potential nature of the coronal global magnetic field is not satisfied even during the deep solar minimum. Results of our 3D density reconstruction will help to constrain solar coronal field models and test the accuracy of the magnetic field approximations for coronal modeling.Comment: Published in "Solar Physics

Anomalous NMR Magnetic Shifts in CeCoIn_5

We report ^{115}In and ^{59}Co Nuclear Magnetic Resonance (NMR) measurements in the heavy fermion superconductor CeCoIn_5 above and below T_c. The hyperfine couplings of the In and Co are anisotropic and exhibit dramatic changes below 50K due to changes in the crystal field level populations of the Ce ions. Below T_c the spin susceptibility is suppressed, indicating singlet pairing.Comment: 4 pages, 4 figure