The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers

This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology. The MSSS correlated with the phosphorylated neurofilament heavy chain (NfH-SMI35, R=0.44, P=0.016). The degree of neurofilament phosphorylation (ratio NfH-SMI34 to NfH-SMI35) was 8-fold higher in severely (median MSSS 6.5) versus mildly (MSSS 3.2) disabled patients (7.3 versus 0.9, P=0.03). The MSSS may provide a statistically powerful tool for comparing overall disease severity and be useful for validating the biomarker concept in MS

Prevalence of methicillin-resistant Staphylococcus aureus among large commercial pig herds in South Africa

The prevalence of nasal carrier status of methicillin-resistant Staphylococcus aureus (MRSA) in pigs has been described elsewhere, but is unknown in South Africa. To address concerns that exist regarding the zoonotic risk that carriers pose to workers, the herd-level prevalence of MRSA was determined among 25 large (> 500 sows) commercial pig herds in South Africa, representing 45% of the large commercial herds in the country. From each herd, the nasal contents of 18 finisher pigs were sampled at the abattoir, pooled into three and selectively cultured to determine the presence of MRSA. A herd was classified as MRSA-positive if one or more of the three pooled samples cultured positive. Three of the 25 herds tested positive for MRSA, equating to a 12% herd prevalence (95% CI: 7% – 23%) among South African commercial piggeries. The prevalence of nasal MRSA carriers among large commercial pig herds in South Africa was low compared to what has been reported elsewhere and suggests a relatively low zoonotic MRSA risk to workers in South African commercial piggeries and abattoirs

Effect of continuum couplings in fusion of halo 11^{11}Be on 208^{208}Pb around the Coulomb barrier

The effect of continuum couplings in the fusion of the halo nucleus $^{11}$Be on $^{208}$Pb around the Coulomb barrier is studied using a three-body model within a coupled discretised continuum channels (CDCC) formalism. We investigate in particular the role of continuum-continuum couplings. These are found to hinder total, complete and incomplete fusion processes. Couplings to the projectile $1p_{1/2}$ bound excited state redistribute the complete and incomplete fusion cross sections, but the total fusion cross section remains nearly constant. Results show that continuum-continuum couplings enhance the irreversibility of breakup and reduce the flux that penetrates the Coulomb barrier. Converged total fusion cross sections agree with the experimental ones for energies around the Coulomb barrier, but underestimate those for energies well above the Coulomb barrier.Comment: 15 pages, 7 figures, accepted in Phys. Rev.

Toward Common Data Elements for International Research in Long-term Care Homes: Advancing Person-Centered Care

To support person-centered, residential long-term care internationally, a consortium of researchers in medicine, nursing, behavioral, and social sciences from 21 geographically and economically diverse countries have launched the WE-THRIVE consortium to develop a common data infrastructure. WE-THRIVE aims to identify measurement domains that are internationally relevant, including in low-, middle-, and high-income countries, prioritize concepts to operationalize domains, and specify a set of data elements to measure concepts that can be used across studies for data sharing and comparisons. This article reports findings from consortium meetings at the 2016 meeting of the Gerontological Society of America and the 2017 meeting of the International Association of Gerontology and Geriatrics, to identify domains and prioritize concepts, following best practices to identify common data elements (CDEs) that were developed through the US National Institutes of Health/National Institute of Nursing Research's CDEs initiative. Four domains were identified, including organizational context, workforce and staffing, person-centered care, and care outcomes. Using a nominal group process, WE-THRIVE prioritized 21 concepts across the 4 domains. Several concepts showed similarity to existing measurement structures, whereas others differed. Conceptual similarity (convergence; eg, concepts in the care outcomes domain of functional level and harm-free care) provides further support of the critical foundational work in LTC measurement endorsed and implemented by regulatory bodies. Different concepts (divergence; eg, concepts in the person-centered care domain of knowing the person and what matters most to the person) highlights current gaps in measurement efforts and is consistent with WE-THRIVE's focus on supporting resilience and thriving for residents, family, and staff. In alignment with the World Health Organization's call for comparative measurement work for health systems change, WE-THRIVE's work to date highlights the benefits of engaging with diverse LTC researchers, including those in low-, middle-, and high-income countries, to develop a measurement infrastructure that integrates the aspirations of person-centered LTC

On the geometrization of matter by exotic smoothness

In this paper we discuss the question how matter may emerge from space. For that purpose we consider the smoothness structure of spacetime as underlying structure for a geometrical model of matter. For a large class of compact 4-manifolds, the elliptic surfaces, one is able to apply the knot surgery of Fintushel and Stern to change the smoothness structure. The influence of this surgery to the Einstein-Hilbert action is discussed. Using the Weierstrass representation, we are able to show that the knotted torus used in knot surgery is represented by a spinor fulfilling the Dirac equation and leading to a mass-less Dirac term in the Einstein-Hilbert action. For sufficient complicated links and knots, there are "connecting tubes" (graph manifolds, torus bundles) which introduce an action term of a gauge field. Both terms are genuinely geometrical and characterized by the mean curvature of the components. We also discuss the gauge group of the theory to be U(1)xSU(2)xSU(3).Comment: 30 pages, 3 figures, svjour style, complete reworking now using Fintushel-Stern knot surgery of elliptic surfaces, discussion of Lorentz metric and global hyperbolicity for exotic 4-manifolds added, final version for publication in Gen. Rel. Grav, small typos errors fixe

Decoherence Strength of Multiple Non-Markovian Environments

It is known that one can characterize the decoherence strength of a Markovian environment by the product of its temperature and induced damping, and order the decoherence strength of multiple environments by this quantity. We show that for non-Markovian environments in the weak coupling regime there also exists a natural (albeit partial) ordering of environment-induced irreversibility within a perturbative treatment. This measure can be applied to both low-temperature and non-equilibrium environments.Comment: 6 pages, 1 figure, v3 included figure, appendix, and clarification of result

Neutralino Dark Matter beyond CMSSM Universality

We study the effect of departures from SUSY GUT universality on the neutralino relic density and both its direct detection and indirect detection, especially by neutrino telescopes. We find that the most interesting models are those with a value of $M_3|_{GUT}$ lower than the universal case.Comment: 20 pages, 12 figures, JHEP format. Figures improved for B&W, references added, typos and english correcte

Modular structures and the delivery of inpatient care in hospitals: a Network Science perspective on healthcare function and dysfunction

Background: Reinforced by the COVID-19 pandemic, the capacity of health systems to cope with increasing healthcare demands has been an abiding concern of both governments and the public. Health systems are made up from non-identical human and physical components interacting in diverse ways in varying locations. It is challeng‑ ing to represent the function and dysfunction of such systems in a scientifc manner. We describe a Network Science approach to that dilemma. General hospitals with large emergency caseloads are the resource intensive components of health systems. We propose that the care-delivery services in such entities are modular, and that their structure and function can be usefully analysed by contemporary Network Science. We explore that possibility in a study of Australian hospitals during 2019 and 2020. Methods: We accessed monthly snapshots of whole of hospital administrative patient level data in two general hospitals during 2019 and 2020. We represented the organisations inpatient services as network graphs and explored their graph structural characteristics using the Louvain algorithm and other methods. We related graph topological features to aspects of observable function and dysfunction in the delivery of care. Results: We constructed a series of whole of institution bipartite hospital graphs with clinical unit and labelled wards as nodes, and patients treated by units in particular wards as edges. Examples of the graphs are provided. Algorithmic identifcation of community structures confrmed the modular structure of the graphs. Their functional implications were readily identifed by domain experts. Topological graph features could be related to functional and dysfunctional issues such as COVID-19 related service changes and levels of hospital congestion. Discussion and conclusions: Contemporary Network Science is one of the fastest growing areas of current scientifc and technical advance. Network Science confrms the modular nature of healthcare service structures. It holds con‑ siderable promise for understanding function and dysfunction in healthcare systems, and for reconceptualising issues such as hospital capacity in new and interesting ways.David I. Ben, Tovim, Mariusz Bajger, Viet Duong Bui, Shaowen Qin, and Campbell H. Thompso

Magnetic Flux of EUV Arcade and Dimming Regions as a Relevant Parameter for Early Diagnostics of Solar Eruptions - Sources of Non-Recurrent Geomagnetic Storms and Forbush Decreases

This study aims at the early diagnostics of geoeffectiveness of coronal mass ejections (CMEs) from quantitative parameters of the accompanying EUV dimming and arcade events. We study events of the 23th solar cycle, in which major non-recurrent geomagnetic storms (GMS) with Dst <-100 nT are sufficiently reliably identified with their solar sources in the central part of the disk. Using the SOHO/EIT 195 A images and MDI magnetograms, we select significant dimming and arcade areas and calculate summarized unsigned magnetic fluxes in these regions at the photospheric level. The high relevance of this eruption parameter is displayed by its pronounced correlation with the Forbush decrease (FD) magnitude, which, unlike GMSs, does not depend on the sign of the Bz component but is determined by global characteristics of ICMEs. Correlations with the same magnetic flux in the solar source region are found for the GMS intensity (at the first step, without taking into account factors determining the Bz component near the Earth), as well as for the temporal intervals between the solar eruptions and the GMS onset and peak times. The larger the magnetic flux, the stronger the FD and GMS intensities are and the shorter the ICME transit time is. The revealed correlations indicate that the main quantitative characteristics of major non-recurrent space weather disturbances are largely determined by measurable parameters of solar eruptions, in particular, by the magnetic flux in dimming areas and arcades, and can be tentatively estimated in advance with a lead time from 1 to 4 days. For GMS intensity, the revealed dependencies allow one to estimate a possible value, which can be expected if the Bz component is negative.Comment: 27 pages, 5 figures. Accepted for publication in Solar Physic

Mechanisms for slow strengthening in granular materials

Several mechanisms cause a granular material to strengthen over time at low applied stress. The strength is determined from the maximum frictional force F_max experienced by a shearing plate in contact with wet or dry granular material after the layer has been at rest for a waiting time \tau. The layer strength increases roughly logarithmically with \tau -only- if a shear stress is applied during the waiting time. The mechanisms of strengthening are investigated by sensitive displacement measurements and by imaging of particle motion in the shear zone. Granular matter can strengthen due to a slow shift in the particle arrangement under shear stress. Humidity also leads to strengthening, but is found not to be its sole cause. In addition to these time dependent effects, the static friction coefficient can also be increased by compaction of the granular material under some circumstances, and by cycling of the applied shear stress.Comment: 21 pages, 11 figures, submitted to Phys. Rev.