1,130 research outputs found
Deflection and Rotation of CMEs from Active Region 11158
Between the 13 and 16 of February 2011 a series of coronal mass ejections
(CMEs) erupted from multiple polarity inversion lines within active region
11158. For seven of these CMEs we use the Graduated Cylindrical Shell (GCS)
flux rope model to determine the CME trajectory using both Solar Terrestrial
Relations Observatory (STEREO) extreme ultraviolet (EUV) and coronagraph
images. We then use the Forecasting a CME's Altered Trajectory (ForeCAT) model
for nonradial CME dynamics driven by magnetic forces, to simulate the
deflection and rotation of the seven CMEs. We find good agreement between the
ForeCAT results and the reconstructed CME positions and orientations. The CME
deflections range in magnitude between 10 degrees and 30 degrees. All CMEs
deflect to the north but we find variations in the direction of the
longitudinal deflection. The rotations range between 5\mydeg and 50\mydeg with
both clockwise and counterclockwise rotations occurring. Three of the CMEs
begin with initial positions within 2 degrees of one another. These three CMEs
all deflect primarily northward, with some minor eastward deflection, and
rotate counterclockwise. Their final positions and orientations, however,
respectively differ by 20 degrees and 30 degrees. This variation in deflection
and rotation results from differences in the CME expansion and radial
propagation close to the Sun, as well as the CME mass. Ultimately, only one of
these seven CMEs yielded discernible in situ signatures near Earth, despite the
active region facing near Earth throughout the eruptions. We suggest that the
differences in the deflection and rotation of the CMEs can explain whether each
CME impacted or missed the Earth.Comment: 18 pages, 6 figures, accepted in Solar Physic
Red Queen Coevolution on Fitness Landscapes
Species do not merely evolve, they also coevolve with other organisms.
Coevolution is a major force driving interacting species to continuously evolve
ex- ploring their fitness landscapes. Coevolution involves the coupling of
species fit- ness landscapes, linking species genetic changes with their
inter-specific ecological interactions. Here we first introduce the Red Queen
hypothesis of evolution com- menting on some theoretical aspects and empirical
evidences. As an introduction to the fitness landscape concept, we review key
issues on evolution on simple and rugged fitness landscapes. Then we present
key modeling examples of coevolution on different fitness landscapes at
different scales, from RNA viruses to complex ecosystems and macroevolution.Comment: 40 pages, 12 figures. To appear in "Recent Advances in the Theory and
Application of Fitness Landscapes" (H. Richter and A. Engelbrecht, eds.).
Springer Series in Emergence, Complexity, and Computation, 201
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness
BACKGROUND:
There are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive care unit (ICU).
METHODS:
In a randomized, double-blind, placebo-controlled trial, we assigned patients with acute respiratory failure or shock and hypoactive or hyperactive delirium to receive intravenous boluses of haloperidol (maximum dose, 20 mg daily), ziprasidone (maximum dose, 40 mg daily), or placebo. The volume and dose of a trial drug or placebo was halved or doubled at 12-hour intervals on the basis of the presence or absence of delirium, as detected with the use of the Confusion Assessment Method for the ICU, and of side effects of the intervention. The primary end point was the number of days alive without delirium or coma during the 14-day intervention period. Secondary end points included 30-day and 90-day survival, time to freedom from mechanical ventilation, and time to ICU and hospital discharge. Safety end points included extrapyramidal symptoms and excessive sedation.
RESULTS:
Written informed consent was obtained from 1183 patients or their authorized representatives. Delirium developed in 566 patients (48%), of whom 89% had hypoactive delirium and 11% had hyperactive delirium. Of the 566 patients, 184 were randomly assigned to receive placebo, 192 to receive haloperidol, and 190 to receive ziprasidone. The median duration of exposure to a trial drug or placebo was 4 days (interquartile range, 3 to 7). The median number of days alive without delirium or coma was 8.5 (95% confidence interval [CI], 5.6 to 9.9) in the placebo group, 7.9 (95% CI, 4.4 to 9.6) in the haloperidol group, and 8.7 (95% CI, 5.9 to 10.0) in the ziprasidone group (P=0.26 for overall effect across trial groups). The use of haloperidol or ziprasidone, as compared with placebo, had no significant effect on the primary end point (odds ratios, 0.88 [95% CI, 0.64 to 1.21] and 1.04 [95% CI, 0.73 to 1.48], respectively). There were no significant between-group differences with respect to the secondary end points or the frequency of extrapyramidal symptoms.
CONCLUSIONS:
The use of haloperidol or ziprasidone, as compared with placebo, in patients with acute respiratory failure or shock and hypoactive or hyperactive delirium in the ICU did not significantly alter the duration of delirium. (Funded by the National Institutes of Health and the VA Geriatric Research Education and Clinical Center; MIND-USA ClinicalTrials.gov number, NCT01211522 .)
Risk Factors for In-hospital Nonhemorrhagic Stroke in Patients With Acute Myocardial Infarction Treated With Thrombolysis: Results from GUSTO-I
BACKGROUND: Nonhemorrhagic stroke occurs in 0.1% to 1.3% of patients with
acute myocardial infarction who are treated with thrombolysis, with
substantial associated mortality and morbidity. Little is known about the
risk factors for its occurrence. METHODS AND RESULTS: We studied the 247
patients with nonhemorrhagic stroke who were randomly assigned to one of
four thrombolytic regimens within 6 hours of symptom onset in the GUSTO-I
trial. We assessed the univariable and multivariable baseline risk factors
for nonhemorrhagic stroke and created a scoring nomogram from the baseline
multivariable modeling. We used time-dependent Cox modeling to determine
multivariable in-hospital predictors of nonhemorrhagic stroke. Baseline
and in-hospital predictors were then combined to determine the overall
predictors of nonhemorrhagic stroke. Of the 247 patients, 42 (17%) died
and another 98 (40%) were disabled by 30-day follow-up. Older age was the
most important baseline clinical predictor of nonhemorrhagic stroke,
followed by higher heart rate, history of stroke or transient ischemic
attack, diabetes, previous angina, and history of hypertension. These
factors remained statistically significant predictors in the combined
model, along with worse Killip class, coronary angiography, bypass
surgery, and atrial fibrillation/flutter. CONCLUSIONS: Nonhemorrhagic
stroke is a serious event in patients with acute myocardial infarction who
are treated with thrombolytic, antithrombin, and antiplatelet therapy. We
developed a simple nomogram that can predict the risk of nonhemorrhagic
stroke on the basis of baseline clinical characteristics. Prophylactic
anticoagulation may be an important treatment strategy for patients with
high probability for nonhemorrhagic stroke, but further study is needed
The VLT-FLAMES Tarantula Survey
A spectroscopic analysis has been undertaken for the B-type multiple systems (excluding those with supergiant primaries) in the VLT-FLAMES Tarantula Survey (VFTS). Projected rotational velocities, vesini, for the primaries have been estimated using a Fourier Transform technique and confirmed by fitting rotationally broadened profiles. A subset of 33 systems with vesini ≤ 80 km s-1 have been analysed using a TLUSTY grid of model atmospheres to estimate stellar parameters and surface abundances for the primaries. The effects of a potential flux contribution from an unseen secondary have also been considered. For 20 targets it was possible to reliably estimate their effective temperatures (Teff) but for the other 13 objects it was only possible to provide a constraint of 20 000 ≤ Teff ≤ 26 000 K – the other parameters estimated for these targets will be consequently less reliable. The estimated stellar properties are compared with evolutionary models and are generally consistent with their membership of 30 Doradus, while the nature of the secondaries of 3 SB2 system is discussed. A comparison with a sample of single stars with vesini ≤ 80 km s-1 obtained from the VFTS and analysed with the same techniques implies that the atmospheric parameters and nitrogen abundances of the two samples are similar. However, the binary sample may have a lack of primaries with significant nitrogen enhancements, which would be consistent with them having low rotational velocities and having effectively evolved as single stars without significant rotational mixing. This result, which may be actually a consequence of the limitations of the pathfinder investigation presented in this paper, should be considered as a motivation for spectroscopic abundance analysis of large samples of binary stars, with high quality observational data
The VLT-FLAMES Tarantula Survey. XXVII:Physical parameters of B-type main-sequence binary systems in the Tarantula nebula
Search for Exotic Mesons in pi- P Interactions at 18 GeV/c
The recent search for non mesons in interactions at
Brookhaven National Laboratory is summarized. Many final states such as , , , , , ,
which are favored decay modes of exotics, are under investigation.Comment: 9 pages, PostScript, Presented at the International School of Nuclear
Physics, Erice, Sicily, Italy, September 199
Confirmation of a pi_1^0 Exotic Meson in the \eta \pi^0 System
The exclusive reaction , at 18 GeV has been studied with a partial wave analysis on a sample
of 23~492 events from BNL experiment E852. A mass-dependent fit
is consistent with a resonant hypothesis for the wave, thus providing
evidence for a neutral exotic meson with , a mass of MeV, and a width of MeV. New
interpretations of the meson exotics in neutral system observed in
E852 and Crystal Barrel experiments are discussed.Comment: p3, rewording the paragraph (at the bottom) about the phase
variations. p4, rewording paragrath "The second method ..." . p4, at the
bottom of paragrath "The third method ..." added consistent with the results
of methods 1 and 2
Magnetoluminescence
Pulsar Wind Nebulae, Blazars, Gamma Ray Bursts and Magnetars all contain
regions where the electromagnetic energy density greatly exceeds the plasma
energy density. These sources exhibit dramatic flaring activity where the
electromagnetic energy distributed over large volumes, appears to be converted
efficiently into high energy particles and gamma-rays. We call this general
process magnetoluminescence. Global requirements on the underlying, extreme
particle acceleration processes are described and the likely importance of
relativistic beaming in enhancing the observed radiation from a flare is
emphasized. Recent research on fluid descriptions of unstable electromagnetic
configurations are summarized and progress on the associated kinetic
simulations that are needed to account for the acceleration and radiation is
discussed. Future observational, simulation and experimental opportunities are
briefly summarized.Comment: To appear in "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray Bursts
and Blazars: Physics of Extreme Energy Release" of the Space Science Reviews
serie
Observation of Pseudoscalar and Axial Vector Resonances in pi- p -> K+ K- pi0 n at 18 GeV
A new measurement of the reaction pi- p -> K+ K- pi0 n has been made at a
beam energy of 18 GeV. A partial wave analysis of the K+ K- pi0 system shows
evidence for three pseudoscalar resonances, eta(1295), eta(1416), and
eta(1485), as well as two axial vectors, f1(1285), and f1(1420). Their observed
masses, widths and decay properties are reported. No signal was observed for
C(1480), an IG J{PC} = 1+ 1{--} state previously reported in phi pi0 decay.Comment: 7 pages, 6 figs, to be submitted to Phys. Let
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