2,510 research outputs found
Thermal/structural analysis of a transpiration cooled nozzle
The 8-foot High Temperature Tunnel (HTT) at LaRC is a combustion driven, high enthalpy blow down wind tunnel. In Mar. 1991, during check out of the transpiration cooled nozzle, pieces of platelets were found in the tunnel test section. It was determined that incorrect tolerancing between the platelets and the housing was the primary cause of the platelet failure. An analysis was performed to determine the tolerance layout between the platelets and the housing to meet the structural and performance criteria under a range of thermal, pressure, and bolt preload conditions. Three recommendations resulted as a product of this analysis
Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study
Objectives The interleukin-6 receptor (IL-6R) blocker tocilizumab (TCZ) reduces inflammatory disease activity in rheumatoid arthritis (RA) but elevates lipid concentrations in some patients. We aimed to characterise the impact of IL-6R inhibition on established and novel risk factors in active RA.
Methods Randomised, multicentre, two-part, phase III trial (24-week double-blind, 80-week open-label), MEASURE, evaluated lipid and lipoprotein levels, high-density lipoprotein (HDL) particle composition, markers of coagulation, thrombosis and vascular function by pulse wave velocity (PWV) in 132 patients with RA who received TCZ or placebo.
Results Median total-cholesterol, low-density lipoprotein-cholesterol (LDL-C) and triglyceride levels increased in TCZ versus placebo recipients by week 12 (12.6% vs 1.7%, 28.1% vs 2.2%, 10.6% vs −1.9%, respectively; all p<0.01). There were no significant differences in mean small LDL, mean oxidised LDL or total HDL-C concentrations. However, HDL-associated serum amyloid A content decreased in TCZ recipients. TCZ also induced reductions (<30%) in secretory phospholipase A2-IIA, lipoprotein(a), fibrinogen and D-dimers and elevation of paraoxonase (all p<0.0001 vs placebo). The ApoB/ApoA1 ratio remained stable over time in both groups. PWV decreases were greater with placebo than TCZ at 12 weeks (adjusted mean difference 0.79 m/s (95% CI 0.22 to 1.35; p=0.0067)).
Conclusions These data provide the first detailed evidence for the modulation of lipoprotein particles and other surrogates of vascular risk with IL-6R inhibition. When compared with placebo, TCZ induced elevations in LDL-C but altered HDL particles towards an anti-inflammatory composition and favourably modified most, but not all, measured vascular risk surrogates. The net effect of such changes for cardiovascular risk requires determination.</p
Omega-3 and Omega-6 Fatty acids and risk of psychotic outcomes in the ALSPAC birth cohort
Background
Long chain polyunsaturated fatty acid (PUFA) levels have been implicated in the pathology of psychotic disorders. We investigated the relationship between childhood PUFA levels and later psychotic experiences (PE's) in a large birth cohort.
Methods
Plasma levels of Ω-3 and Ω-6 fatty acids (FA's) were assayed at ages 7 and 16 years. PE's were assessed at ages 12 and 18 years using a semi-structured interview. Primary outcome was any PE's at 18 years; sensitivity analyses examined incident PE's between ages 12 and 18 years, persistent PE's (at 12 and 18) and psychotic disorder at 18 years. Genetic instruments for Ω-3 and Ω-6 were derived and used in a multivariable Mendelian Randomization analysis.
Results
Higher levels of Ω-6 FA's AA, OA and AdA at age 7 years were weakly associated with a reduced risk for PE's at 18 years, however, effect sizes were small and attenuated after adjusting for confounders (strongest evidence for OA; adjusted OR, 0.842; 95% CI, 0.711, 0.998; p, 0.048). Total Ω-6 levels at age 16 years were associated with an increased odds of psychotic disorder at age 18 years. However, there was no association between Ω-6/Ω-3 ratio and psychosis outcomes, nor with genetic instruments of total Ω-3 or Ω-6 levels.
Conclusions
There is no strong evidence that total plasma Ω-3 FA levels or Ω-6/Ω-3 ratios in childhood and mid-adolescence are associated with increased risk for PE's or psychotic disorder, but very marginal evidence that alterations in the Ω-6 pathway at developmental time points might influence risk2
Measuring Transit Signal Recovery in the Kepler Pipeline II: Detection Efficiency as Calculated in One Year of Data
The Kepler planet sample can only be used to reconstruct the underlying
planet occurrence rate if the detection efficiency of the Kepler pipeline is
known, here we present the results of a second experiment aimed at
characterising this detection efficiency. We inject simulated transiting planet
signals into the pixel data of ~10,000 targets, spanning one year of
observations, and process the pixels as normal. We compare the set of
detections made by the pipeline with the expectation from the set of simulated
planets, and construct a sensitivity curve of signal recovery as a function of
the signal-to-noise of the simulated transit signal train. The sensitivity
curve does not meet the hypothetical maximum detection efficiency, however it
is not as pessimistic as some of the published estimates of the detection
efficiency. For the FGK stars in our sample, the sensitivity curve is well fit
by a gamma function with the coefficients a = 4.35 and b = 1.05. We also find
that the pipeline algorithms recover the depths and periods of the injected
signals with very high fidelity, especially for periods longer than 10 days. We
perform a simplified occurrence rate calculation using the measured detection
efficiency compared to previous assumptions of the detection efficiency found
in the literature to demonstrate the systematic error introduced into the
resulting occurrence rates. The discrepancies in the calculated occurrence
rates may go some way towards reconciling some of the inconsistencies found in
the literature.Comment: 13 pages, 7 figures, 1 electronic table, accepted by Ap
Measuring Transit Signal Recovery in the Kepler Pipeline. III. Completeness of the Q1-Q17 DR24 Planet Candidate Catalogue, with Important Caveats for Occurrence Rate Calculations
With each new version of the Kepler pipeline and resulting planet candidate
catalogue, an updated measurement of the underlying planet population can only
be recovered with an corresponding measurement of the Kepler pipeline detection
efficiency. Here, we present measurements of the sensitivity of the pipeline
(version 9.2) used to generate the Q1-Q17 DR24 planet candidate catalog
(Coughlin et al. 2016). We measure this by injecting simulated transiting
planets into the pixel-level data of 159,013 targets across the entire Kepler
focal plane, and examining the recovery rate. Unlike previous versions of the
Kepler pipeline, we find a strong period dependence in the measured detection
efficiency, with longer (>40 day) periods having a significantly lower
detectability than shorter periods, introduced in part by an incorrectly
implemented veto. Consequently, the sensitivity of the 9.2 pipeline cannot be
cast as a simple one-dimensional function of the signal strength of the
candidate planet signal as was possible for previous versions of the pipeline.
We report on the implications for occurrence rate calculations based on the
Q1-Q17 DR24 planet candidate catalog and offer important caveats and
recommendations for performing such calculations. As before, we make available
the entire table of injected planet parameters and whether they were recovered
by the pipeline, enabling readers to derive the pipeline detection sensitivity
in the planet and/or stellar parameter space of their choice.Comment: 8 pages, 5 figures, full electronic version of Table 1 available at
the NASA Exoplanet Archive; accepted by ApJ May 2nd, 201
Detection Of KOI-13.01 Using The Photometric Orbit
We use the KOI-13 transiting star-planet system as a test case for the
recently developed BEER algorithm (Faigler & Mazeh 2011), aimed at identifying
non-transiting low-mass companions by detecting the photometric variability
induced by the companion along its orbit. Such photometric variability is
generated by three mechanisms, including the beaming effect, tidal ellipsoidal
distortion, and reflection/heating. We use data from three Kepler quarters,
from the first year of the mission, while ignoring measurements within the
transit and occultation, and show that the planet's ephemeris is clearly
detected. We fit for the amplitude of each of the three effects and use the
beaming effect amplitude to estimate the planet's minimum mass, which results
in M_p sin i = 9.2 +/- 1.1 M_J (assuming the host star parameters derived by
Szabo et al. 2011). Our results show that non-transiting star-planet systems
similar to KOI-13.01 can be detected in Kepler data, including a measurement of
the orbital ephemeris and the planet's minimum mass. Moreover, we derive a
realistic estimate of the amplitudes uncertainties, and use it to show that
data obtained during the entire lifetime of the Kepler mission, of 3.5 years,
will allow detecting non-transiting close-in low-mass companions orbiting
bright stars, down to the few Jupiter mass level. Data from the Kepler Extended
Mission, if funded by NASA, will further improve the detection capabilities.Comment: Accepted to AJ on October 4, 2011. Kepler Q5 Long Cadence data will
become publicly available on MAST by October 23. Comments welcome (V2: minor
changes, to reflect proof corrections
Built Environment Interventions for Human and Planetary Health:Integrating Health in Climate Change Adaption and Mitigation
Objectives: Human-generated climate change is causing adverse health effects through multiple direct pathways (e.g. heatwaves, sea-level rise, storm frequency and intensity) and indirect pathways (e.g. food and water insecurity, social instability). Although the health system has a key role to play in addressing these health effects, so too do those professions tasked with the development of the built environment (urban and regional planners, urban designers, landscapers and architects), through improvements to buildings, streets, neighbourhoods, suburbs and cities. This article reports on the ways in which urban planning and design, and architectural interventions, can address the health effects of climate change; and the scope of climate change adaptation and mitigation approaches being implemented by the built environment professions.
Type of program or service: Built environment adaptations and mitigations and their connections to the ways in which urban planning, urban design and architectural practices are addressing the health effects of climate change.
Methods: Our reflections draw on the findings of a recent review of existing health and planning literature. First, we explore the ways in which ‘adaptation’ and ‘mitigation’ relate to the notion of human and planetary health. We then outline the broad scope of adaptation and mitigation interventions being envisioned, and in some instances actioned, by built environment professionals.
Results: Analysis of the review’s findings reveals that adaptations developed by built environment professions predominantly focus on protecting human health and wellbeing from the effects of climate change. In contrast, built environment mitigations address climate change by embracing a deeper understanding of the co-benefits inherent in the interconnectedness of human health and wellbeing and the health of the ecosystem on which it depends. In the final section, we highlight the ethical transition that these approaches demand of built environment professions.
Lessons learnt: Built environment interventions must move beyond simple ecological sustainability to encouraging ways of life that are healthy for both humans and the planet. There are key challenges facing this new approach
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