An Update on the Consequences of EU Sugar Reform

Since its formation the European Union (EU) has employed a rather complicated policy to ensure high prices to domestic sugar growers and trade preferences to certain sugar exporting countries, e.g. the African Caribbean and Pacific (ACP) group. One result of this policy is that the EU has been both the second largest importer and second largest exporter in the world market. Under pressure from the World Trade Organization (WTO), the EU agreed to reform its policies toward sugar in 2001, with the full effect of the reforms being fully implemented in 2006. In this paper, the impact of the sugar reform on EU production, consumption, imports, and exports is examined especially with regard to how it all affects the ACP countries who receive preferential treatment regarding access to EU sugar markets. Preliminary analysis indicates that lowering domestic EU prices, while quotas requirements for ACP countries remain intact might have negative revenue implications for poor sugar producers

Towards a foundation for holistic power system validation and testing

Renewable energy sources and further electrificationof energy consumption are key enablers for decreasing green-house gas emissions, but also introduce increased complexitywithin the electric power system. The increased availability ofautomation, information and communication technology, andintelligent solutions for system operation have transformed thepower system into a smart grid. In order to support thedevelopment process of smart grid solutions on the system level,testing has to be done in a holistic manner, covering the multi-domain aspect of such complex systems. This paper introducesthe concept of holistic power system testing and discuss first stepstowards a corresponding methodology that is being developed inthe European ERIGrid research infrastructure project.Comment: 2016 IEEE 21st International Conference on Emerging Technologies and Factory Automation (ETFA

Occurrence of pathogenic Vibrio cholerae serogroups 01 and 0139 in some estuaries of Tanzania

In this study, the occurrence of culturable Vibrio cholerae serogroup O1 and O139 in three selected Tanzanian Estuaries, Mzinga, Pangani and Ruvu were explored. A total of 480 water and plankton samples were collected along salinity gradients (fresh, brackish and marine waters). Samples were enriched in Alkaline Peptone Water (APW) and subsequently cultured on Thiosulfate Citrate Bile-Salt Sucrose (TCBS) agar. Resulting isolates were serially identified by oxidase test, API-20E test and monoclonal antibodies for V. cholerae serogroup O1 and O139. A total of 670 presumptive V. cholerae isolates were obtained from 416 samples (86.7%), where 137 (20.4%) were oxidase test positive. Out of the oxidase test positive, 96 (70.8%) were further confirmed by API 20E to be V. cholerae while only 8 isolates were ascertained by monoclonal antibodies to be V. cholerae O1 and 1 isolate to be V. cholerae O139. This indicated that, apart from the few V. cholerae O1 and O139 confirmed serogroups, there is still a large percentage of V. cholerae non-O1/O139. Similarly, both V. Cholerae serogroups O1 and non-O1/O139 were observed in clinical samples suggesting a close link between the existence of the bacterium in aquatic environments and cholera outbreak.Key words: Tanzanian Estuaries, V. cholerae, serogroupO1/O13

Co-variations of Cholera with Climatic and Environmental Parameters in Coastal Regions of Tanzania

The bacterium causing cholera, Vibrio cholerae, is essentially a marine organism and its ecological dynamics have been linked to oceanographic conditions and climate. We used autoregressive models with external inputs to identify potential relationships between number of cholera cases in the coastal regions of mainland Tanzania with climatic and environmental indices (maximum air temperature, sea surface temperature, wind speed and chlorophyll a). Results show that between 2004 and 2010 coastal regions of mainland Tanzania with approximately 21% of the total population accounted for approximately 50% of the cases and 40% of the total mortality. Significant co-variations were found between seasonally adjusted cases and coastal ocean chlorophyll a and to some degree sea surface temperature, both lagged by one to four months. Cholera cases in Dar es Salaam were also weakly related to the Indian Ocean Dipole Mode Index lagged by 5 months, suggesting that it may be possible to predict Cholera outbreaks for Dar es Salaam 5 months ahead of time. The results also suggest that the severity of cholera in coastal regions is set by conditions in the ocean and that longer-term environmental and climate parameters may be used to predict cholera outbreaks along the coastal regions

National South African HIV prevalence estimates robust despite substantial test non-participation

Background. South African (SA) national HIV seroprevalence estimates are of crucial policy relevance in the country, and for the worldwide HIV response. However, the most recent nationally representative HIV test survey in 2012 had 22% test non-participation, leaving the potential for substantial bias in current seroprevalence estimates, even after controlling for selection on observed factors. Objective. To re-estimate national HIV prevalence in SA, controlling for bias due to selection on both observed and unobserved factors in the 2012 SA National HIV Prevalence, Incidence and Behaviour Survey. Methods. We jointly estimated regression models for consent to test and HIV status in a Heckman-type bivariate probit framework. As selection variable, we used assigned interviewer identity, a variable known to predict consent but highly unlikely to be associated with interviewees’ HIV status. From these models, we estimated the HIV status of interviewed participants who did not test. Results. Of 26 710 interviewed participants who were invited to test for HIV, 21.3% of females and 24.3% of males declined. Interviewer identity was strongly correlated with consent to test for HIV; declining a test was weakly associated with HIV serostatus. Our HIV prevalence estimates were not significantly different from those using standard methods to control for bias due to selection on observed factors: 15.1% (95% confidence interval (CI) 12.1 - 18.6) v. 14.5% (95% CI 12.8 - 16.3) for 15 - 49-year-old males; 23.3% (95% CI 21.7 - 25.8) v. 23.2% (95% CI 21.3 - 25.1) for 15 - 49-year-old females. Conclusion. The most recent SA HIV prevalence estimates are robust under the strongest available test for selection bias due to missing data. Our findings support the reliability of inferences drawn from such data

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: A phase 1 dose-escalation study

BackgroundThis phase 1 dose-escalation trial studied MM-302, a novel HER2-targeted PEGylated antibody-liposomal doxorubicin conjugate, in HER2-positive locally advanced/metastatic breast cancer.MethodsPatients were enrolled in four cohorts: MM-302 monotherapy (8, 16, 30, 40, and 50 mg/m2 every 4 weeks [q4w]); MM-302 (30 or 40 mg/m2 q4w) plus trastuzumab (4 mg/kg q2w); MM-302 (30 mg/m2) plus trastuzumab (6 mg/kg) q3w; MM-302 (30 mg/m2) plus trastuzumab (6 mg/kg) and cyclophosphamide (450 mg/m2) q3w.ResultsSixty-nine patients were treated. The most common adverse events (AEs) were fatigue and nausea. Grade 3/4 AEs of special interest included neutropenia, fatigue, mucosal inflammation, anemia, thrombocytopenia, febrile neutropenia, and palmar-plantar erythrodysesthesia. The MTD was not reached. With MM-302 ≥ 30 mg/m2, overall response rate (ORR) was 13% and median progression-free survival (mPFS) 7.4 months (95% CI: 3·5-10·9) in all arms. In 25 anthracycline-naïve patients, ORR was 28·0% and mPFS 10·9 months (95% CI: 1·8-15·3). Imaging with 64Cu-labeled MM-302 visualized tumor-drug penetrance in tumors throughout the body, including the brain.ConclusionMM-302 monotherapy, in combination with trastuzumab, or trastuzumab plus cyclophosphamide, was well tolerated and showed promising efficacy. The selected phase 2 MM-302 dose was 30 mg/m2 plus 6 mg/kg trastuzumab q3w

Validating Intelligent Power and Energy Systems { A Discussion of Educational Needs

Traditional power systems education and training is flanked by the demand for coping with the rising complexity of energy systems, like the integration of renewable and distributed generation, communication, control and information technology. A broad understanding of these topics by the current/future researchers and engineers is becoming more and more necessary. This paper identifies educational and training needs addressing the higher complexity of intelligent energy systems. Education needs and requirements are discussed, such as the development of systems-oriented skills and cross-disciplinary learning. Education and training possibilities and necessary tools are described focusing on classroom but also on laboratory-based learning methods. In this context, experiences of using notebooks, co-simulation approaches, hardware-in-the-loop methods and remote labs experiments are discussed.Comment: 8th International Conference on Industrial Applications of Holonic and Multi-Agent Systems (HoloMAS 2017