62 research outputs found
Trying Cases in the Media: Legal Ethics, Fair Trials and Free Press
The 2000 symposium consisted of a panel discussion which used role-playing and a mock trial to highlight the issues of lawyer/litigant comments to the press before and during trial and the dilemma of journalists confronted by court demands for documents, testimony, or sources of information obtained in the course of gathering news on pending trials. Participants included:
As United States Attorney for the Eastern District of Freedonia: John Douglas, Associate Professor of Law at the University of Richmond.
As Freedonia criminal defense lawyer: Gerald Zerkin, Private Defense Attorney.
As investigative journalist: Steve Nash, Associate Professor of Journalism at the University of Richmond.
As federal judge: Judge Margaret P. Spencer, Virginia Circuit Court Judge.
As media attorney: Craig Thomas Merritt, Attorney.
As first amendment attorney: J. Joshua Wheeler, Attorney and Director of Programs for the Thomas Jefferson Center for the Protection of Free Expression, and adjunct professor at University of Virginia.
As Chief Justice: Paul D. Carrington, The Chadwick Professor of Law at Duke University.
As Associate Justices of the United States Supreme Court: C. Thomas Dienes, Patricia Roberts Harris Professor of Law at George Washington University\u27s Law School; John E. Nowak, David C. Baum Professor of Law at the University of Illinois; Molly Delea, third-year law student, University of Richmond School of Law; Kate Murray, third-year law student, University of Richmond School of Law; Thomas Queen, third-year law student, University of Richmond School of Law; and Courtney Sydnor, third-year law student, University of Richmond School of Law
Impact of Skeletal Complications on Total Medical Care Costs among Patients with Bone Metastases of Lung Cancer
IntroductionPrevious studies have estimated the costs of skeletal-related events (SREs) for patients with bone metastases of solid tumors by tallying costs for services specifically attributable to these events. This approach may underestimate costs if SREs indirectly increase use of other services.MethodsThis is a retrospective observational study using a large health insurance claims database. Patients with bone metastases of lung cancer who experienced ≥1 SRE were matched to similar patients without SREs based on propensity scores. Kaplan-Meier estimated total medical care costs were compared for propensity-matched samples of patients with SREs and without SREs.ResultsWe identified 534 patients with lung cancer and bone metastases, including 295 (55%) with ≥1 SRE. After matching, there were 162 patients each in the SRE and no-SRE groups with mean follow-up of 5.3 and 3.9 months, respectively. In the SRE group, costs of treatment of SREs were 7,625 to 27,982 (95% CI 40,625) greater for SRE versus no-SRE patients (p < 0.001).ConclusionsThe costs of SREs in patients with lung cancer and bone metastases are substantial and potentially greater than previously estimated
Efficacy and safety of fluticasone/formoterol combination therapy in patients with moderate-to-severe asthma
Background: The inhaled corticosteroid, fluticasone propionate, and the long-acting b2-adrenergic agonist, formoterol fumarate, are both highly effective treatments for bronchial asthma.
This study (NCT00393952/EudraCT number: 2006-005989-39) compared the efficacy and safety
of fluticasone/formoterol combination therapy (flutiform®; 250/10 mg) administered twice
daily (b.i.d.) via a single aerosol inhaler, with the individual components (fluticasone 250 mg
b.i.d.; formoterol 10 mg b.i.d.), in adult and adolescent patients with moderate-to-severe
asthma.
Methods: This was a 12-week, double-blind, randomised, parallel-group, multicentre, placebocontrolled phase 3 study. The co-primary efficacy endpoints were: i) the mean change in
the forced expiratory volume in the first second (FEV1) from morning pre-dose at baseline to
pre-dose at week 12 (fluticasone/formoterol 250/10 mg vs. formoterol), ii) the mean change
in FEV1 from morning pre-dose at baseline to 2 h post-dose at week 12 (fluticasone/formoterol
250/10 mg vs. fluticasone), and iii) the number of patients who discontinued prematurely due
to lack of treatment efficacy (fluticasone/formoterol 250/10 mg vs. placebo). The secondary
endpoints included measures of lung function, disease control, and asthma symptoms. Safety
was assessed based on adverse events, vital signs, and clinical laboratory evaluations.
Results: Overall, 395 (70.9%) patients completed the study. Fluticasone/formoterol 250/10 mg
b.i.d. was superior to the individual components and placebo for all three co-primary endpoints and demonstrated numerically greater improvements for multiple secondary
efficacy analyses. Fluticasone/formoterol combination therapy had a good safety profile over
the 12 weeks.
Conclusion: Fluticasone/formoterol combination therapy will provide clinicians with an efficacious alternative treatment option for patients with moderate-to-severe asthma
Preferences of Canadian Patients and Physicians for Adjuvant Treatments for Melanoma
Background: Past research suggests that patients with early- and late-stage melanoma will endure adverse events and inconvenient treatment regimens for improved survival. Evidence about the preferences of Canadian patients and physicians for novel adjuvant treatments for melanoma is unavailable. Methods: Patient and physician preferences for adjuvant treatments for melanoma were assessed in an online discrete choice experiment (dce). Treatment alternatives were characterized by 8 attributes with respect to dosing regimen, efficacy, and toxicities, with levels corresponding to those for dabrafenib–trametinib, nivolumab, pembrolizumab, and interferon. For patients, the effects of melanoma on quality of life and ability to work and perform activities of daily living were also assessed. Patients were recruited by Canadian melanoma patient advocacy groups through e-mail and social media. Physicians were recruited by e-mail. Results: Of 94 patients who started the survey, 51 completed 1 or more dce questions. Of 166 physicians sent the e-mail invitation, 18 completed 1 or more dce questions. For patients, an increased probability of remaining cancer-free over 21 months was the most important attribute. For physicians, an increased chance of the patient’s remaining alive over 36 months was the most important attribute. Patients and physicians chose active treatment over no treatment 85% and 86% of the time respectively and a treatment with attributes consistent with dabrafenib–trametinib 71% and 67% of the time respectively. A substantial proportion of patients reported worrying about future diagnostic tests and their cancer coming back. Conclusions: Canadian patients and physicians are generally concordant in their preferences for adjuvant melanoma treatments, preferring active treatment to no treatment and dabrafenib–trametinib to other options
Network Meta-analysis of Progression-Free Survival and Overall Survival in First-Line Treatment of BRAF Mutation-Positive Metastatic Melanoma
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