Training oncology physicians to advise their patients on complementary and integrative medicine: An implementation study for a manual‐guided consultation

Background: The unmonitored use of complementary medicine in patients with cancer can be associated with an increased risk of safety-related issues, such as lower adherence to conventional cancer therapies. Training oncology physicians to advise their patients about the effectiveness and safety of these therapies could improve this situation. Methods: The objective of this study was to develop and pretest a consultation framework that has high potential to be widely implemented. The framework comprises: 1) a systematically developed and tested, manualized, guided consultation; and 2) blended learning training (e-learning and communication skills training workshop) to upskill oncology physicians in advising their patients on complementary and integrative medicine (CIM). For this implementation study, mixed methods were used to develop the manual (literature review, consensus procedure, pilot testing) and the training (questionnaires and interviews with oncology physicians and patients with cancer and an examination of the skills in a setting with standardized patients). Results: The training was tested with 47 oncology physicians from across Germany. The manual-guided consultation (context: general information on the setting and communication techniques; inform: consultation duration and content; capture: previous CIM use; prioritize: focus on consultation; advise: evidence-based CIM recommendations; discuss, advise, accept, or advise against other CIM; concretize advice: summary and implementation; and monitor: documentation) was considered suitable. The structure and time frame (maximum, 20 minutes) of the consultation as well as the training were feasible and well accepted. Conclusions: The current study demonstrates that the KOKON-KTO framework (a German acronym for Competence Network for Complementary Medicine - Consultation Training for Oncology Physicians) is suitable for training oncology physicians. Its implementation can lead to better physician-patient communication about CIM in cancer

A Selberg integral for the Lie algebra A_n

A new q-binomial theorem for Macdonald polynomials is employed to prove an A_n analogue of the celebrated Selberg integral. This confirms the g=A_n case of a conjecture by Mukhin and Varchenko concerning the existence of a Selberg integral for every simple Lie algebra g.Comment: 32 page

Thomae type formulae for singular Z_N curves

We give an elementary and rigorous proof of the Thomae type formula for singular $Z_N$ curves. To derive the Thomae formula we use the traditional variational method which goes back to Riemann, Thomae and Fuchs.Comment: 22 page

A Polynomial-Time Key-Recovery Attack on MQQ Cryptosystems

International audienceWe investigate the security of the family of MQQ public key cryptosystems using multivariate quadratic quasigroups (MQQ). These cryptosystems show especially good performance properties. In particular, the MQQ-SIG signature scheme is the fastest scheme in the ECRYPT benchmarking of cryptographic systems (eBACS). We show that both the signature scheme MQQ-SIG and the encryption scheme MQQ-ENC, although using different types of MQQs, share a common algebraic structure that introduces a weakness in both schemes. We use this weakness to mount a successful polynomial time key-recovery attack. Our key-recovery attack finds an equivalent key using the idea of so-called {\it good keys} that reveals the structure gradually. In the process we need to solve a MinRank problem that, because of the structure, can be solved in polynomial-time assuming some mild algebraic assumptions. We highlight that our theoretical results work in characteristic $2$ which is known to be the most difficult case to address in theory for MinRank attacks. Also, we emphasize that our attack works without any restriction on the number of polynomials removed from the public-key, that is, using the minus modifier. This was not the case for previous MinRank like-attacks against \MQ\ schemes. From a practical point of view, we are able to break an MQQ-SIG instance of $80$ bits security in less than $2$ days, and one of the more conservative MQQ-ENC instances of $128$ bits security in little bit over $9$ days. Altogether, our attack shows that it is very hard to design a secure public key scheme based on an easily invertible MQQ structure

Cryptanalysis of The Lifted Unbalanced Oil Vinegar Signature Scheme

In 2017, Ward Beullens \textit{et al.} submitted Lifted Unbalanced Oil and Vinegar (LUOV)\cite{beullens2017field}, a signature scheme based on the famous multivariate public key cryptosystem (MPKC) called Unbalanced Oil and Vinegar (UOV), to NIST for the competition for post-quantum public key scheme standardization. The defining feature of LUOV is that, though the public key $\mathcal{P}$ works in the extension field of degree $r$ of $\mathbb{F}_2$, the coefficients of $\mathcal{P}$ come from $\mathbb{F}_2$. This is done to significantly reduce the size of $\mathcal{P}$. The LUOV scheme is now in the second round of the NIST PQC standardization process. In this paper we introduce a new attack on LUOV. It exploits the lifted structure of LUOV to reduce direct attacks on it to those over a subfield. We show that this reduces the complexity below the targeted security for the NIST post-quantum standardization competition

Many Labs 5:Testing pre-data collection peer review as an intervention to increase replicability

Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect (p < .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3?9; median total sample = 1,279.5, range = 276?3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (?r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols (r = .05) was similar to that of the RP:P protocols (r = .04) and the original RP:P replications (r = .11), and smaller than that of the original studies (r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00?.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19?.50)

Development, Implementation, and Evaluation of an e-Learning in Integrative Oncology for Physicians and Students Involving Experts and Learners: Experiences and Recommendations

In this project, an e-Learning program for complementary and integrative medicine in oncology was systematically developed, implemented, and evaluated in a stepwise procedure. Learning objectives and content were defined within the KOKON project network, considering the educational competencies for integrative oncology. To design a valuable e-Learning, experts were involved in all relevant steps of the process, as well as stakeholders from various target groups (undergraduates: medicine students, postgraduates: oncology physicians). We used mixed methods including quantitative surveys, progress tests, and qualitative focus groups. The developed e-Learning program led to a significant measurable knowledge gain about complementary and integrative medicine. In parallel, physicians and students were subjectively satisfied with the training. For the majority of e-Learning elements, the needs of both target groups are comparable. Furthermore, both groups emphasized the value of formative assessment tools for gaining knowledge. From the various surveys and experiences collected in this project, we derive recommendations for others developing e-Learning programs