Diagnostic and prognostic value of plasma volume status at emergency department admission in dyspneic patients: results from the PARADISE cohort

International audienceBackground:Systemic congestion, evaluated by estimated plasma volume status (ePVS), is associated with in-hospital mortality in acute heart failure (AHF). However, the diagnostic and prognostic value of ePVS in patients with acute dyspnea has been insufficiently studied.-- Objectives:To assess the association between the first ePVS calculated from blood samples on admission in the emergency department (ED) and discharge diagnosis of AHF and in-hospital mortality in patients admitted for acute dyspnea.-- Methods:The study included 1369 patients admitted for dyspnea in the ED in 2015. ePVS was calculated from hematocrit and hemoglobin values at admission. Comparisons of baseline characteristics according to ePVS tertiles were carried out and then associations between ePVS and the two outcomes “AHF diagnosis” and “intra-hospital mortality” were assessed using a logistic regression model.-- Results:36.6% had a BNP > 400 pg/mL and median ePVS was 4.58 dL/g [3.96–5.55]. Overall in-hospital mortality was 11.1% (n = 149). In multivariable analysis, the third ePVS tertile (> 5.12 dL/g) had a significantly increased risk of having AHF (OR = 1.64 [1.16–2.33], p = 0.005). In-hospital mortality rose across ePVS tertiles (8.4–13.8% p < 0.01). ePVS greater than the first or second tertile threshold (respectively, 4.17 dL/g and 5.12 dL/g) were both significantly associated with a higher risk of in-hospital mortality (OR for 2nd/3rd tertile = 2.06 [1.25–3.38], p = 0.004 and OR for 3rd tertile = 1.54 [1.01–2.36], p = 0.04).-- Conclusion:Higher ePVS values determined from first blood sample at admission are associated with a higher probability of AHF and in-hospital mortality in patients admitted in the ED for acute dyspnea

First measurement of the ∣t∣|t|-dependence of incoherent J/ψ\psi photonuclear production

International audienceThe first measurement of the cross section for incoherent photonuclear production of J/$\psi$ vector meson as a function of the Mandelstam $|t|$ variable is presented. The measurement was carried out with the ALICE detector at midrapidity, $|y|<0.8$, using ultra-peripheral collisions of Pb nuclei at a centre-of-mass energy per nucleon pair $\sqrt{s_{\mathrm{NN}}} = 5.02$ TeV. This rapidity interval corresponds to a Bjorken-$x$ range $(0.3$$-$$1.4)\times 10^{-3}$. Cross sections are reported in five $|t|$ intervals in the range $0.04<|t|<1$~GeV$^2$ and compared to the predictions of different models. Models that ignore quantum fluctuations of the gluon density in the colliding hadron predict a $|t|$-dependence of the cross section much steeper than in data. The inclusion of such fluctuations in the same models provides a better description of the data

Charged-particle production as a function of the relative transverse activity classifier in pp, p−-Pb, and Pb−-Pb collisions at the LHC

International audienceMeasurements of charged-particle production in pp, p$-$Pb, and Pb$-$Pb collisions in the toward, away, and transverse regions with the ALICE detector are discussed. These regions are defined event-by-event relative to the azimuthal direction of the charged trigger particle, which is the reconstructed particle with the largest transverse momentum ($p_{\mathrm{T}}^{\rm trig}$) in the range $8<p_{\mathrm{T}}^{\rm trig}<15$ GeV$/c$. The toward and away regions contain the primary and recoil jets, respectively; both regions are accompanied by the underlying event (UE). In contrast, the transverse region perpendicular to the direction of the trigger particle is dominated by the so-called UE dynamics, and includes also contributions from initial- and final-state radiation. The relative transverse activity classifier, $R_{\mathrm{T}}=N_{\mathrm{ch}}^{\mathrm{T}}/\langle N_{\mathrm{ch}}^{\mathrm{T}}\rangle$, is used to group events according to their UE activity, where $N_{\mathrm{ch}}^{\mathrm{T}}$ is the charged-particle multiplicity per event in the transverse region and $\langle N_{\mathrm{ch}}^{\mathrm{T}}\rangle$ is the mean value over the whole analysed sample. The energy dependence of the $R_{\mathrm{T}}$ distributions in pp collisions at $\sqrt{s}=2.76$, 5.02, 7, and 13 TeV is reported, exploring the Koba-Nielsen-Olesen (KNO) scaling properties of the multiplicity distributions. The first measurements of charged-particle $p_{\rm T}$ spectra as a function of $R_{\mathrm{T}}$ in the three azimuthal regions in pp, p$-$Pb, and Pb$-$Pb collisions at $\sqrt{s_{\rm NN}}=5.02$ TeV are also reported. Data are compared with predictions obtained from the event generators PYTHIA 8 and EPOS LHC. This set of measurements is expected to contribute to the understanding of the origin of collective-like effects in small collision systems (pp and p$-$Pb)

Charm production and fragmentation fractions at midrapidity in pp collisions at s=13\sqrt{s} = 13 TeV

International audienceMeasurements of the production cross sections of prompt ${\rm D^0}$, ${\rm D^+}$, ${\rm D^{\ast +}}$, ${\rm D_s^+}$, ${\rm \Lambda_{c}^{+}}$, and ${\rm \Xi_{c}^{+}}$ charm hadrons at midrapidity in proton$-$proton collisions at $\sqrt{s}=13$ TeV with the ALICE detector are presented. The D-meson cross sections as a function of transverse momentum ($p_{\rm T}$) are provided with improved precision and granularity. The ratios of $p_{\rm T}$-differential meson production cross sections based on this publication and on measurements at different rapidity and collision energy provide a constraint on gluon parton distribution functions at low values of Bjorken-$x$ ($10^{-5}-10^{-4}$). The measurements of ${\rm \Lambda_{c}^{+}}$ (${\rm \Xi_{c}^{+}}$) baryon production extend the measured $p_{\rm T}$ intervals down to $p_{\rm T}=0(3)$~GeV$/c$. These measurements are used to determine the charm-quark fragmentation fractions and the ${\rm c\overline{c}}$ production cross section at midrapidity ($|y|<0.5$) based on the sum of the cross sections of the weakly-decaying ground-state charm hadrons ${\rm D^0}$, ${\rm D^+}$, ${\rm D_s^+}$, ${\rm \Lambda_{c}^{+}}$, ${\rm \Xi_{c}^{0}}$ and, for the first time, ${\rm \Xi_{c}^{+}}$, and of the strongly-decaying J/$psi$ mesons. The first measurements of ${\rm \Xi_{c}^{+}}$ and ${\rm \Sigma_{c}^{0,++}}$ fragmentation fractions at midrapidity are also reported. A significantly larger fraction of charm quarks hadronising to baryons is found compared to e$^+$e$^-$ and ep collisions. The ${\rm c\overline{c}}$ production cross section at midrapidity is found to be at the upper bound of state-of-the-art perturbative QCD calculations

Dielectron production in central Pb−-Pb collisions at sNN\sqrt{s_\mathrm{NN}} = 5.02 TeV

International audienceThe first measurement of the e$^+$e$^-$ pair production at midrapidity and low invariant mass in central Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV at the LHC is presented. The yield of e$^+$e$^-$ pairs is compared with a cocktail of expected hadronic decay contributions in the invariant mass ($m_{\rm ee}$) and pair transverse momentum ($p_{\rm T,ee}$) ranges $m_{\rm ee} < 3.5$ GeV$/c^2$ and $p_{\rm T,ee} < 8$ GeV$/c$. For $0.18 < m_{\rm ee} < 0.5$ GeV$/c^2$ the ratio of data to the cocktail of hadronic contributions without $\rho$ mesons amounts to $1.42 \pm 0.12 \ ({\rm stat.}) \pm 0.17 \ ({\rm syst.}) \pm 0.12 \ ({\rm cocktail})$ and $1.44 \pm 0.12 \ ({\rm stat.}) \pm 0.17 \ ({\rm syst.}) ^{+0.17}_{-0.21} \ ({\rm cocktail})$, including or not including medium effects in the estimation of the heavy-flavor background, respectively. It is consistent with predictions from two different models for an additional contribution of thermal e$^+$e$^-$ pairs from the hadronic and partonic phases. In the intermediate-mass range ($1.2 < m_{\rm ee} < 2.6$ GeV$/c^2$), the pair transverse impact parameter of the e$^+$e$^-$ pairs (DCA$_{\rm ee}$) is used for the first time in Pb$-$Pb collisions to separate displaced dielectrons from heavy-flavor hadron decays from a possible (thermal) contribution produced at the interaction point. The data are consistent with a suppression of e$^+$e$^-$ pairs from ${\rm c\overline{c}}$ and an additional prompt component. Finally, the first direct-photon measurement in the 10% most central Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV is reported via the study of virtual direct photons in the transverse momentum range $1 < p_{\rm T} < 5$ GeV$/c$. A model including prompt photons, as well as photons from the pre-equilibrium and fluid-dynamic phases, can reproduce the result, while being at the upper edge of the data uncertainties

Dielectron production in central Pb−-Pb collisions at sNN\sqrt{s_\mathrm{NN}} = 5.02 TeV

International audienceThe first measurement of the e$^+$e$^-$ pair production at midrapidity and low invariant mass in central Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV at the LHC is presented. The yield of e$^+$e$^-$ pairs is compared with a cocktail of expected hadronic decay contributions in the invariant mass ($m_{\rm ee}$) and pair transverse momentum ($p_{\rm T,ee}$) ranges $m_{\rm ee} < 3.5$ GeV$/c^2$ and $p_{\rm T,ee} < 8$ GeV$/c$. For $0.18 < m_{\rm ee} < 0.5$ GeV$/c^2$ the ratio of data to the cocktail of hadronic contributions without $\rho$ mesons amounts to $1.42 \pm 0.12 \ ({\rm stat.}) \pm 0.17 \ ({\rm syst.}) \pm 0.12 \ ({\rm cocktail})$ and $1.44 \pm 0.12 \ ({\rm stat.}) \pm 0.17 \ ({\rm syst.}) ^{+0.17}_{-0.21} \ ({\rm cocktail})$, including or not including medium effects in the estimation of the heavy-flavor background, respectively. It is consistent with predictions from two different models for an additional contribution of thermal e$^+$e$^-$ pairs from the hadronic and partonic phases. In the intermediate-mass range ($1.2 < m_{\rm ee} < 2.6$ GeV$/c^2$), the pair transverse impact parameter of the e$^+$e$^-$ pairs (DCA$_{\rm ee}$) is used for the first time in Pb$-$Pb collisions to separate displaced dielectrons from heavy-flavor hadron decays from a possible (thermal) contribution produced at the interaction point. The data are consistent with a suppression of e$^+$e$^-$ pairs from ${\rm c\overline{c}}$ and an additional prompt component. Finally, the first direct-photon measurement in the 10% most central Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV is reported via the study of virtual direct photons in the transverse momentum range $1 < p_{\rm T} < 5$ GeV$/c$. A model including prompt photons, as well as photons from the pre-equilibrium and fluid-dynamic phases, can reproduce the result, while being at the upper edge of the data uncertainties

Study of flavor dependence of the baryon-to-meson ratio in proton-proton collisions at s=13\sqrt{s} = 13 TeV

International audienceThe production cross sections of ${\rm D^0}$ and $\Lambda^+_{\rm c}$ hadrons originating from beauty-hadron decays (i.e. non-prompt) were measured for the first time at midrapidity ($|y|<0.5$) by the ALICE Collaboration in proton-proton collisions at a center-of-mass energy $\sqrt{s}=13$ TeV. They are described within uncertainties by perturbative QCD calculations employing the fragmentation fractions of beauty quarks to baryons measured at forward rapidity by the LHCb Collaboration. The ${\rm b\overline{b}}$ production cross section per unit of rapidity at midrapidity, estimated from these measurements, is ${\rm d}\sigma_{\rm b\overline{b}}/{\rm d}y|_{|y|<0.5} = 83.1 \pm 3.5 (\mathrm{stat.}) \pm 5.4(\mathrm{syst.}) ^{+12.3}_{-3.2} (\mathrm{extrap.})\,\mu$b. The baryon-to-meson ratios are computed to investigate the hadronization mechanism of beauty quarks. The non-prompt $\Lambda^+_{\rm c}/{\rm D^0}$ production ratio has a similar trend to the one measured for the promptly produced charmed particles and to the p$/\pi^+$ and $\Lambda/{\rm K^0_S}$ ratios, suggesting a similar baryon-formation mechanism among light, strange, charm, and beauty hadrons. The $p_{\rm T}$-integrated non-prompt $\Lambda_{\rm c}/{\rm D^0}$ ratio is found to be significantly higher than the one measured in e$^+$e$^-$ collisions