Treatment of multidrug-resistant tuberculosis in a remote, conflict-affected area of the Democratic Republic of Congo.

The Democratic Republic of Congo is a high-burden country for multidrug-resistant tuberculosis. Médecins Sans Frontières has supported the Ministry of Health in the conflict-affected region of Shabunda since 1997. In 2006, three patients were diagnosed with drug-resistant TB (DR-TB) and had no options for further treatment. An innovative model was developed to treat these patients despite the remote setting. Key innovations were the devolving of responsibility for treatment to non-TB clinicians remotely supported by a TB specialist, use of simplified monitoring protocols, and a strong focus on addressing stigma to support adherence. Treatment was successfully completed after a median of 24 months. This pilot programme demonstrates that successful treatment for DR-TB is possible on a small scale in remote settings

Assessment of RNAi-induced silencing in banana (Musa spp.)

In plants, RNA- based gene silencing mediated by small RNAs functions at the transcriptional or post-transcriptional level to negatively regulate target genes, repetitive sequences, viral RNAs and/or transposon elements. Post-transcriptional gene silencing (PTGS) or the RNA interference (RNAi) approach has been achieved in a wide range of plant species for inhibiting the expression of target genes by generating double-stranded RNA (dsRNA). However, to our knowledge, successful RNAi-application to knock-down endogenous genes has not been reported in the important staple food crop banana

First occurrence of the little-known genus Noteriades (Hymenoptera, Megachilidae) from Vietnam: discovery of a new species and a key to the Southeast Asian fauna

The little-known megachiline genus Noteriades Cockerell, 1931 is recorded from Vietnam for the first time. A new species, Noteriades hangkia Tran, Engel & Nguyen sp. nov. is described and figured based on a series of females collected from the provinces of the northern and central highlands of Vietnam. The genus is briefly discussed and a new subtribe is established, Noteriadina Engel, Tran & Nguyen subtrib. nov. of Megachilini. Lastly, an identification key and distribution map are provided for those species occurring in Southeast Asia

Analysis and development prospects of electronic and mobile payments in Russia

The article analyses electronic systems development, its impact on the development of the economy and a number of sectors of life. It enumerates and analyses basic forms of ecash circulation. The article demonstrates the need for development of this sphere of economy as well as financial systems

Tuberculosis treatment in a refugee and migrant population: 20 years of experience on the Thai-Burmese border.

Although tuberculosis (TB) is a curable disease, it remains a major global health problem and an important cause of morbidity and mortality among vulnerable populations, including refugees and migrants

Developing trends in showrooming, webrooming, and omnichannel shopping behaviors: Performance analysis, conceptual mapping, and future directions

In an omnichannel era, businesses and marketers need insights into the dynamics of customer shopping behaviors, particularly the interplay between omnichannel, showrooming, and webrooming behaviors. This study investigates the evolution and trends of the research and channel shopping behaviors (RCSB) domain, spanning from 1998 to 2022, including the Covid-19 era. The study performed a bibliometric review of 500 papers in the Scopus database. The performance analysis reveals an annual growth rate of nearly 16%, with average citations per document of 44, indicating sustained and growing research interest. Science mapping revealed five distinct cluster themes, including showrooming and webrooming in multi- and omni-channel contexts; consumer behavior in online retail and shopping; customer satisfaction and trust in multi-channel retailing; mobile commerce in a multi-channel environment; and the interplay between online shopping, channel choice, and supply chain management. Furthermore, topics, such as showrooming, e-commerce, retailing, and omnichannel retailing, remain popular before and during the pandemic, as seen in the thematic evolution. Our examination of the thematic maps revealed various topics that gained significance during the pandemic, such as multichannel, channel choice, customer experience, social commerce, purchase behavior, and covid-19. Among these, the thematic maps indicate that customer experience, channel choice, multichannel, and covid-19 are emerging and basic topics. These topics can steer research directions in the RCSB domain toward examining customer experiences using digital innovations, e-commerce (including mobile and social commerce), and omnichannel strategy and management

Water depletion in the disk atmosphere of Herbig AeBe stars

We present high resolution (R = 100,000) L-band spectroscopy of 11 Herbig AeBe stars with circumstellar disks. The observations were obtained with the VLT/CRIRES to detect hot water and hydroxyl radical emission lines previously detected in disks around T Tauri stars. OH emission lines are detected towards 4 disks. The OH P4.5 (1+,1-) doublet is spectrally resolved as well as the velocity profile of each component of the doublet. Its characteristic double-peak profile demonstrates that the gas is in Keplerian rotation and points to an emitting region extending out to ~ 15-30 AU. The OH, emission correlates with disk geometry as it is mostly detected towards flaring disks. None of the Herbig stars analyzed here show evidence of hot water vapor at a sensitivity similar to that of the OH lines. The non-detection of hot water vapor emission indicates that the atmosphere of disks around Herbig AeBe stars are depleted of water molecules. Assuming LTE and optically thin emission we derive a lower limit to the OH/H2O column density ratio > 1 - 25 in contrast to T Tauri disks for which the column density ratio is 0.3 -- 0.4.Comment: Accepted for publication in Ap

Herschel evidence for disk flattening or gas depletion in transitional disks

Transitional disks are protoplanetary disks characterized by reduced near- and mid-infrared emission with respect to full disks. This characteristic spectral energy distribution indicates the presence of an optically thin inner cavity within the dust disk believed to mark the disappearance of the primordial massive disk. We present new Herschel Space Observatory PACS spectra of [OI] 63 micron for 21 transitional disks. Our survey complements the larger Herschel GASPS program "Gas in Protoplanetary Systems" (Dent et al. 2013) by quadrupling the number of transitional disks observed with PACS at this wavelength. [OI] 63 micron traces material in the outer regions of the disk, beyond the inner cavity of most transitional disks. We find that transitional disks have [OI] 63 micron line luminosities two times fainter than their full disk counterparts. We self consistently determine various stellar properties (e.g. bolometric luminosity, FUV excess, etc.) and disk properties (e.g. disk dust mass, etc.) that could influence the [OI] 63 micron line luminosity and we find no correlations that can explain the lower [OI] 63 micron line luminosities in transitional disks. Using a grid of thermo-chemical protoplanetary disk models, we conclude that either transitional disks are less flared than full disks or they possess lower gas-to-dust ratios due to a depletion of gas mass. This result suggests that transitional disks are more evolved than their full disk counterparts, possibly even at large radii.Comment: Accepted for publication in ApJ; 52 pages, 16 figures, 8 table

The potter wasp genus Allorhynchium from Vietnam, with descriptions of three new species and a new country record (Hymenoptera, Vespidae, Eumeninae)

Species of the potter wasp genus Allorhynchium van der Vecht (Eumeninae: Odynerini) occurring in Vietnam are presented. Seven species have been recorded from Vietnam. Of them, three species are described as new to science: Allorhynchium latum Nguyen, Tran & MT Nguyen, sp. nov., A. moerum Nguyen & AD Nguyen, sp. nov., and A. setosum Nguyen & Engel, sp. nov., and one species, A. argentatum (Fabricius, 1804), is recorded from Vietnam for the first time. An updated key to the Oriental species of the genus is presented