Erdwolf oder Schwein? Ein Vergleich von Archäologie und schriftlichem Material

The article lists the occurrences of the Egyptian word HDr, which so far has remained an enigmatic term for some kind of animal. Mainly on the basis of the analogies with other words, it is argued here that this animal is not an aardwolf but rather a pig or a wild boar. In support of this, a number of examples are cited from various Semitic languages of the Ancient Near East

Searching for a Source of the Coptic Hemerology

The article offers a study of the known Coptic calendars with favorable and unfavorable days, entitled hemerologies, and compares the given information with the information presented in earlier calendars from Egypt and Mycenaean Greece and also with later sources written in Arabic and Latin. The starting point of this study is Pap. Heidelberg Inv. Kopt. 236, a newly edited Coptic hemerology which forms the second oldest example of this type known so far. In comparison, the material clearly shows that predictions for certain days are not necessarily results of direct influences and can be seen as examples of cultural convergences.Der vorliegende Beitrag bietet eine Studie zu den bisher bekannten koptischen Kalendern mit günstigen und ungünstigen Tagen, welche als Hemerologien bezeichnet werden, und vergleicht diese sowie die in ihnen vorliegenden Informationen mit früheren Kalendern aus Ägypten und der mykenischen Kultur wie auch mit späteren Quellen auf Arabisch und Latein. Den Ausgangspunkt der Studie bildet Pap. Heidelberg Inv. Kopt. 236, eine neu edierte koptische Hemerologie und bisher das zweitälteste Exemplar dieser Gattung. Im Vergleich zeigen die heute bekannten Texte klar, dass Vorhersagen für bestimmte Tage nicht zwangsläufig auf direkte Einflüsse zwischen Kulturen zurückzuführen sein müssen, sondern als Beispiele für kulturelle Gemeinsamkeiten gelten können

Long-term patient-important outcomes after septic shock : A protocol for 1-year follow-up of the CLASSIC trial

BackgroundIn patients with septic shock, mortality is high, and survivors experience long-term physical, mental and social impairments. The ongoing Conservative vs Liberal Approach to fluid therapy of Septic Shock in Intensive Care (CLASSIC) trial assesses the benefits and harms of a restrictive vs standard-care intravenous (IV) fluid therapy. The hypothesis is that IV fluid restriction improves patient-important long-term outcomes. AimTo assess the predefined patient-important long-term outcomes in patients randomised into the CLASSIC trial. MethodsIn this pre-planned follow-up study of the CLASSIC trial, we will assess all-cause mortality, health-related quality of life (HRQoL) and cognitive function 1 year after randomisation in the two intervention groups. The 1-year mortality will be collected from electronic patient records or central national registries in most participating countries. We will contact survivors and assess EuroQol 5-Dimension, -5-Level (EQ-5D-5L) and EuroQol-Visual Analogue Scale and Montreal Cognitive Assessment 5-minute protocol score. We will analyse mortality by logistic regression and use general linear models to assess HRQoL and cognitive function. DiscussionWith this pre-planned follow-up study of the CLASSIC trial, we will provide patient-important data on long-term survival, HRQoL and cognitive function of restrictive vs standard-care IV fluid therapy in patients with septic shock.Peer reviewe

Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial-Protocol and statistical analysis plan

Introduction Intravenous (IV) fluid is a key intervention in the management of septic shock. The benefits and harms of lower versus higher fluid volumes are unknown and thus clinical equipoise exists. We describe the protocol and detailed statistical analysis plan for the conservative versus liberal approach to fluid therapy of septic shock in the Intensive Care (CLASSIC) trial. The aim of the CLASSIC trial is to assess benefits and harms of IV fluid restriction versus standard care in adult intensive care unit (ICU) patients with septic shock. Methods CLASSIC trial is an investigator-initiated, international, randomised, stratified, and analyst-blinded trial. We will allocate 1554 adult patients with septic shock, who are planned to be or are admitted to an ICU, to IV fluid restriction versus standard care. The primary outcome is mortality at day 90. Secondary outcomes are serious adverse events (SAEs), serious adverse reactions (SARs), days alive at day 90 without life support, days alive and out of the hospital at day 90 and mortality, health-related quality of life (HRQoL), and cognitive function at 1 year. We will conduct the statistical analyses according to a pre-defined statistical analysis plan, including three interim analyses. For the primary analysis, we will use logistic regression adjusted for the stratification variables comparing the two interventions in the intention-to-treat (ITT) population. Discussion The CLASSIC trial results will provide important evidence to guide clinicians' choice regarding the IV fluid therapy in adults with septic shock.Peer reviewe

Furosemide versus placebo for fluid overload in intensive care patients—The randomised GODIF trial second version : Statistical analysis plan

Publisher Copyright: © 2023 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.Background: Fluid overload is associated with increased mortality in intensive care unit (ICU) patients. The GODIF trial aims to assess the benefits and harms of fluid removal with furosemide versus placebo in stable adult patients with moderate to severe fluid overload in the ICU. This article describes the detailed statistical analysis plan for the primary results of the second version of the GODIF trial. Methods: The GODIF trial is an international, multi-centre, randomised, stratified, blinded, parallel-group, pragmatic clinical trial, allocating 1000 adult ICU patients with moderate to severe fluid overload 1:1 to furosemide versus placebo. The primary outcome is days alive and out of hospital within 90 days post-randomisation. With a power of 90% and an alpha level of 5%, we may reject or detect an improvement of 8%. The primary analyses of all outcomes will be performed in the intention-to-treat population. For the primary outcome, the Kryger Jensen and Lange method will be used to compare the two treatment groups adjusted for stratification variables supplemented with sensitivity analyses in the per-protocol population and with further adjustments for prognostic variables. Secondary outcomes will be analysed with multiple linear regressions, logistic regressions or the Kryger Jensen and Lange method as suitable with adjustment for stratification variables. Conclusion: The GODIF trial data will increase the certainty about the effects of fluid removal using furosemide in adult ICU patients with fluid overload. Trial Registrations: EudraCT identifier: 2019-004292-40 and ClinicalTrials.org: NCT04180397.Peer reviewe

Searching for a Source of the Coptic Hemerology

The article offers a study of the known Coptic calendars with favorable and unfavorable days, entitled hemerologies, and compares the given information with the information presented in earlier calendars from Egypt and Mycenaean Greece and also with later sources written in Arabic and Latin. The starting point of this study is Pap. Heidelberg Inv. Kopt. 236, a newly edited Coptic hemerology which forms the second oldest example of this type known so far. In comparison, the material clearly shows that predictions for certain days are not necessarily results of direct influences and can be seen as examples of cultural convergences

Zur Frage des Mäzens im Prolog des Lucidarius

The present article offers a discussion of the opinions of Joachim Bumke and Georg Steer, whether Prolog A or Prolog B of the Lucidarius is the more original version; furthermore, the opinions are compared with an approach by Marlies Heinz. The question of 'one Duke Henry' can be asked with a special focus on the attribution of medieval works

Erdwolf oder Schwein? Ein Vergleich von Archäologie und schriftlichem Material

The article lists the occurrences of the Egyptian word HDr, which so far has remained an enigmatic term for some kind of animal. Mainly on the basis of the analogies with other words, it is argued here that this animal is not an aardwolf but rather a pig or a wild boar. In support of this, a number of examples are cited from various Semitic languages of the Ancient Near East