475 research outputs found
Optimized Two-Baseline Beta-Beam Experiment
We propose a realistic Beta-Beam experiment with four source ions and two
baselines for the best possible sensitivity to theta_{13}, CP violation and
mass hierarchy. Neutrinos from 18Ne and 6He with Lorentz boost gamma=350 are
detected in a 500 kton water Cerenkov detector at a distance L=650 km (first
oscillation peak) from the source. Neutrinos from 8B and 8Li are detected in a
50 kton magnetized iron detector at a distance L=7000 km (magic baseline) from
the source. Since the decay ring requires a tilt angle of 34.5 degrees to send
the beam to the magic baseline, the far end of the ring has a maximum depth of
d=2132 m for magnetic field strength of 8.3 T, if one demands that the fraction
of ions that decay along the straight sections of the racetrack geometry decay
ring (called livetime) is 0.3. We alleviate this problem by proposing to trade
reduction of the livetime of the decay ring with the increase in the boost
factor of the ions, such that the number of events at the detector remains
almost the same. This allows to substantially reduce the maximum depth of the
decay ring at the far end, without significantly compromising the sensitivity
of the experiment to the oscillation parameters. We take 8B and 8Li with
gamma=390 and 656 respectively, as these are the largest possible boost factors
possible with the envisaged upgrades of the SPS at CERN. This allows us to
reduce d of the decay ring by a factor of 1.7 for 8.3 T magnetic field.
Increase of magnetic field to 15 T would further reduce d to 738 m only. We
study the sensitivity reach of this two baseline two storage ring Beta-Beam
experiment, and compare it with the corresponding reach of the other proposed
facilities.Comment: 17 pages, 3 eps figures. Minor changes, matches version accepted in
JHE
, and the neutrino mass hierarchy at a double baseline Li/B -Beam
We consider a -Beam facility where Li and B ions are
accelerated at , accumulated in a 10 Km storage ring and let
decay, so as to produce intense and beams. These beams
illuminate two iron detectors located at Km and
Km, respectively. The physics potential of this setup is analysed in full
detail as a function of the flux. We find that, for the highest flux ( ion decays per year per baseline), the sensitivity to
reaches ; the sign of
the atmospheric mass difference can be identified, regardless of the true
hierarchy, for ; and, CP-violation
can be discovered in 70% of the -parameter space for , having some sensitivity to CP-violation down to
for .Comment: 35 pages, 20 figures. Minor changes, matches the published versio
BGWM as Second Constituent of Complex Matrix Model
Earlier we explained that partition functions of various matrix models can be
constructed from that of the cubic Kontsevich model, which, therefore, becomes
a basic elementary building block in "M-theory" of matrix models. However, the
less topical complex matrix model appeared to be an exception: its
decomposition involved not only the Kontsevich tau-function but also another
constituent, which we now identify as the Brezin-Gross-Witten (BGW) partition
function. The BGW tau-function can be represented either as a generating
function of all unitary-matrix integrals or as a Kontsevich-Penner model with
potential 1/X (instead of X^3 in the cubic Kontsevich model).Comment: 42 page
Agency and exploitation:Two sides of one coin? Women’s experiences of selling sex and engaging with NGOs in Dhaka
Neutrino Probes of the Nature of Light Dark Matter
Dark matter particles gravitationally trapped inside the Sun may annihilate
into Standard Model particles, producing a flux of neutrinos. The prospects of
detecting these neutrinos in future multi-\kton{} neutrino detectors designed
for other physics searches are explored here. We study the capabilities of a
34/100 \kton{} liquid argon detector and a 100 \kton{} magnetized iron
calorimeter detector. These detectors are expected to determine the energy and
the direction of the incoming neutrino with unprecedented precision allowing
for tests of the dark matter nature at very low dark matter masses, in the
range of 5-50 GeV. By suppressing the atmospheric background with angular cuts,
these techniques would be sensitive to dark matter - nucleon spin dependent
cross sections at the fb level, reaching down to a few ab for the most
favorable annihilation channels and detector technology.Comment: Minor changes and clarifications, matches JCAP versio
Intercalibration of the barrel electromagnetic calorimeter of the CMS experiment at start-up
Calibration of the relative response of the individual channels of the barrel electromagnetic calorimeter of the CMS detector was accomplished, before installation, with cosmic ray muons and test beams. One fourth of the calorimeter was exposed to a beam of high energy electrons and the relative calibration of the channels, the intercalibration, was found to be reproducible to a precision of about 0.3%. Additionally, data were collected with cosmic rays for the entire ECAL barrel during the commissioning phase. By comparing the intercalibration constants obtained with the electron beam data with those from the cosmic ray data, it is demonstrated that the latter provide an intercalibration precision of 1.5% over most of the barrel ECAL. The best intercalibration precision is expected to come from the analysis of events collected in situ during the LHC operation. Using data collected with both electrons and pion beams, several aspects of the intercalibration procedures based on electrons or neutral pions were investigated
A review of diagnostic and functional imaging in headache
The neuroimaging of
headache patients has revolutionised
our understanding of the pathophysiology
of primary headaches and provided
unique insights into these syndromes.
Modern imaging studies
point, together with the clinical picture,
towards a central triggering
cause. The early functional imaging
work using positron emission
tomography shed light on the genesis
of some syndromes, and has
recently been refined, implying that
the observed activation in migraine
(brainstem) and in several trigeminal-autonomic headaches (hypothalamic
grey) is involved in the pain
process in either a permissive or
triggering manner rather than simply
as a response to first-division nociception
per se. Using the advanced
method of voxel-based morphometry,
it has been suggested that there
is a correlation between the brain
area activated specifically in acute
cluster headache — the posterior
hypothalamic grey matter — and an
increase in grey matter in the same
region. No structural changes have
been found for migraine and medication
overuse headache, whereas
patients with chronic tension-type
headache demonstrated a significant
grey matter decrease in regions
known to be involved in pain processing.
Modern neuroimaging thus
clearly suggests that most primary
headache syndromes are predominantly
driven from the brain, activating
the trigeminovascular reflex and
needing therapeutics that act on both
sides: centrally and peripherally
Analysis of the heart rate variability in negative functional states in the course of psychological relaxation sessions
Exome sequencing of family trios from the National Birth Defects Prevention Study: Tapping into a rich resource of genetic and environmental data
Background: The National Birth Defects Prevention Study (NBDPS) is a multisite, population-based, case–control study of genetic and nongenetic risk factors for major structural birth defects. Eligible women had a pregnancy affected by a birth defect or a liveborn child without a birth defect between 1997 and 2011. They were invited to complete a telephone interview to collect pregnancy exposure data and were mailed buccal cell collection kits to collect specimens from themselves, their child (if living), and their child's father. Over 23,000 families representing more than 30 major structural birth defects provided DNA specimens. Methods: To evaluate their utility for exome sequencing (ES), specimens from 20 children with colonic atresia were studied. Evaluations were conducted on specimens collected using cytobrushes stored and transported in open versus closed packaging, on native genomic DNA (gDNA) versus whole genome amplified (WGA) products and on a library preparation protocol adapted to low amounts of DNA. Results: The DNA extracted from brushes in open packaging yielded higher quality sequence data than DNA from brushes in closed packaging. Quality metrics of sequenced gDNA were consistently higher than metrics from corresponding WGA products and were consistently high when using a low input protocol. Conclusions: This proof-of-principle study established conditions under which ES can be applied to NBDPS specimens. Successful sequencing of exomes from well-characterized NBDPS families indicated that this unique collection can be used to investigate the roles of genetic variation and gene–environment interaction effects in birth defect etiologies, providing a valuable resource for birth defect researchers
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study
Comprehensivemetabolite profiling capturesmany highly heritable traits, including amino acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better understand the contribution of genetic variation to amino acid levels, we performed single variant and gene-based tests of association between nine serumamino acids (alanine, glutamine, glycine, histidine, isoleucine, leucine, phenylalanine, tyrosine, and valine) and 16.6million genotyped and imputed variants in 8545 nondiabetic Finnishmen fromtheMETabolic Syndrome In Men (METSIM) study with replication in Northern Finland Birth Cohort (NFBC1966).We identified five novel loci associated with amino acid levels (P = < 5×10-8): LOC157273/PPP1R3B with glycine (rs9987289, P = 2.3×10-26); ZFHX3 (chr16:73326579,minor allele frequency (MAF) = 0.42%, P = 3.6×10-9), LIPC (rs10468017, P = 1.5×10-8), and WWOX (rs9937914, P = 3.8×10-8) with alanine; and TRIB1 with tyrosine (rs28601761, P = 8×10-9). Gene-based tests identified two novel genes harboringmissense variants ofMAF < 1% that show aggregate association with amino acid levels: PYCR1 with glycine (Pgene = 1.5×10-6) and BCAT2 with valine (Pgene = 7.4×10-7); neither gene was implicated by single variant association tests. These findings are among the first applications of gene-based tests to identify new loci for amino acid levels. In addition to the seven novel gene associations, we identified five independent signals at established amino acid loci, including two rare variant signals at GLDC (rs138640017,MAF=0.95%, Pconditional = 5.8×10-40) with glycine levels and HAL (rs141635447,MAF = 0.46%, Pconditional = 9.4×10-11) with histidine levels. Examination of all single variant association results in our data revealed a strong inverse relationship between effect size and MAF (Ptrend < 0.001). These novel signals provide further insight into the molecularmechanisms of amino acidmetabolismand potentially, their perturbations in disease
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