Phenotypic heterogeneity in cystic fibrosis

We have confirmed heterogenity in CF using a different combination of primary clinical variables than those used in previous studies. Subgroupings of individuals with similar levels of sweat chloride were independent of the clustering based on level of pancreatic enzyme supplementation and degree of pulmonary involvement. Data from families with multiple CF children are consistent with the hypothesis that the genetic etiology of CF involves two or more genes that modify the expression of the primary gene defect.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38234/1/1320130209_ftp.pd

National Foundation of the March of Dimes Plaque

Wood, metal, and velvet plaque. The plaque reads, Presented to The Honorable Kenneth M. Curtis 1967 State Chairman for Outstanding Leadership in the fight against birth defects Basil O\u27Connor President .https://digitalcommons.usm.maine.edu/gov_curtis/1020/thumbnail.jp