High lateral portal for sparing the infrapatellar fat-pad during ACL reconstruction

SummaryDuring arthroscopic ACL reconstruction, intra-articular visualization can be compromised by the interposition of the infrapatellar fat pad (IPFP) between the scope and the notch. In this technical note, we describe our technique of using lateral higher arthroscopic portal, starting arthroscopy with the resection of the ligamentum mucosum and performing the tibial tunnel in 40° of knee flexion to optimise the intra-articular view without IPFP debridement. This technique was performed in 112 consecutive arthroscopic ACL reconstructions and compared to that in the previous 112 cases in which a conventional method was used. The use of this technique was associated with a shorter operative time and no increase in the difficulty in performing associated meniscal procedures

Arthrogenic muscle inhibition after ACL reconstruction: a scoping review of the efficacy of interventions

Objective: To determine whether reported therapeutic interventions for arthrogenic muscle inhibition (AMI) in patients with ACL injuries, following ACL reconstruction, or in laboratory studies of AMI, are effective in improving quadriceps activation failure when compared with standard therapy in control groups. Design: A scoping review of the efficacy of interventions was conducted in accordance with the methodological framework of Arksey and O'Malley and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Search terms included 'arthrogenic muscle inhibition', 'quadriceps activation following knee injuries', 'anterior cruciate' or 'knee’ combined with 'quadriceps activation', 'quadriceps inhibition', 'corticomotor', 'arthrogenic', 'brain activation' and 'neuroplasticity'. Articles were evaluated for risk of bias using the PEDro (Physiotherapy Evidence Database) criteria. The overall quality of evidence for each intervention was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE). Data sources: PubMed, EMBASE and Cumulative Index to Nursing and Allied Health Literature databases. Eligibility criteria for selecting studies: Isolated case reports and articles reporting outcomes in patients with chronic disease or major trauma were excluded. All other original research articles were included. Results: 780 potential articles were identified. 20 met the inclusion criteria. These studies provided a moderate quality of evidence to support the efficacy of cryotherapy and physical exercises in the management of AMI. There was low-quality evidence for efficacy of neuromuscular electrical stimulation and transcutaneous electrical nerve stimulation, and very low-quality evidence for efficacy of ultrasound and vibration. Conclusions: This scoping review demonstrated moderate-quality evidence for the efficacy of cryotherapy and physical exercises in improving quadriceps activation failure after ACL injury and reconstruction. These therapeutic modalities are therefore recommended in the management of AMI

Anterolateral ligament reconstruction protects the repaired medial meniscus: a comparative study of 383 anterior cruciate ligament reconstructions from the SANTI study group with a minimum follow-up of 2 years

Background: The prevalence of osteoarthritis after successful meniscal repair is significantly less than that after failed meniscal repair. Study Design: Cohort study; Level of evidence, 3. Purpose: The aim of this study was to determine whether the addition of anterolateral ligament reconstruction (ALLR) confers a protective effect on medial meniscal repair performed at the time of anterior cruciate ligament reconstruction (ACLR). Methods: Retrospective analysis of prospectively collected data was performed to include all patients who had undergone primary ACLR with concomitant posterior horn medial meniscal repair through a posteromedial portal between January 2013 and August 2015. ACLR autograft choice was bone–patellar tendon–bone, hamstring tendons (or quadrupled hamstring tendons), or quadrupled semitendinosus tendon graft with or without ALLR. At the end of the study period, all patients were contacted to determine if they had undergone reoperation. A Kaplan-Meier survival curve was plotted, and a Cox proportional hazards regression model was used to perform multivariate analysis. Results: 383 patients (mean ± SD age, 27.4 ± 9.2 years) were included with a mean follow-up of 37.4 months (range, 24-54.9 months): 194 patients underwent an isolated ACLR, and 189 underwent a combined ACLR + ALLR. At final follow-up, there was no significant difference between groups in postoperative side-to-side laxity (isolated ACLR group, 0.9 ± 0.9 mm [min to max, –1 to 3]; ACLR + ALLR group, 0.8 ± 1.0 mm [min to max, –2 to 3]; P = .2120) or Lysholm score (isolated ACLR group, 93.0 [95% CI, 91.3-94.7]; ACLR + ALLR group, 93.7 [95% CI, 92.3-95.1]; P = .556). Forty-three patients (11.2%) underwent reoperation for failure of the medial meniscal repair or a new tear. The survival rates of meniscal repair at 36 months were 91.2% (95% CI, 85.4%-94.8) in the ACLR + ALLR group and 83.8% (95% CI, 77.1%-88.7%; P = .033) in the ACLR group. The probability of failure of medial meniscal repair was >2 times lower in patients with ACLR + ALLR as compared with patients with isolated ACLR (hazard ratio, 0.443; 95% CI, 0.218-0.866). No other prognosticators of meniscal repair failure were identified. Conclusion: Combined ACLR and ALLR is associated with a significantly lower rate of failure of medial meniscal repairs when compared with those performed at the time of isolated ACLR

How to rapidly abolish knee extension deficit after injury or surgery: a practice-changing video pearl from the Scientific Anterior Cruciate Ligament Network International (SANTI) Study Group

Knee extension deficit is frequently observed after anterior cruciate ligament reconstruction or rupture and other acute knee injuries. Loss of terminal extension often occurs because of hamstring contracture and quadriceps inactivation rather than mechanical intra-articular pathology. Failure to regain full extension in the first few weeks after anterior cruciate ligament reconstruction is a recognized risk factor for adverse long-term outcomes, and therefore, it is important to try to address it. In this technical note, a simple, rapid, and effective technique to help regain full knee extension and abolish quadriceps activation failure is described

Immune Responses Elicited in Tertiary Lymphoid Tissues Display Distinctive Features

During chronic inflammation, immune effectors progressively organize themselves into a functional tertiary lymphoid tissue (TLT) within the targeted organ. TLT has been observed in a wide range of chronic inflammatory conditions but its pathophysiological significance remains unknown. We used the rat aortic interposition model in which a TLT has been evidenced in the adventitia of chronically rejected allografts one month after transplantation. The immune responses elicited in adventitial TLT and those taking place in spleen and draining lymph nodes (LN) were compared in terms of antibody production, T cell activation and repertoire perturbations. The anti-MHC humoral response was more intense and more diverse in TLT. This difference was associated with an increased percentage of activated CD4+ T cells and a symmetric reduction of regulatory T cell subsets. Moreover, TCR repertoire perturbations in TLT were not only increased and different from the common pattern observed in spleen and LN but also “stochastic,” since each recipient displayed a specific pattern. We propose that the abnormal activation of CD4+ T cells promotes the development of an exaggerated pathogenic immune humoral response in TLT. Preliminary findings suggest that this phenomenon i) is due to a defective immune regulation in this non-professional inflammatory-induced lymphoid tissue, and ii) also occurs in human chronically rejected grafts

Combined ACL and anterolateral ligament reconstruction

Background: Clinical results of combined anterior cruciate ligament (ACL) and anterolateral ligament (ALL) reconstruction demonstrate a significant reduction in ACL graft rupture rates and improved return to sport when compared to isolated ACL reconstruction (ACLR). This is supported by laboratory studies which demonstrate that combined ACLR and lateral extra-articular tenodesis (LET) procedures protect the ACL graft by load sharing with it and also by more reliably restoring normal knee kinematics, when compared to isolated ACLR. Description: The ACL graft is formed from a tripled semitendinosus tendon and a single strand of gracilis. The femoral tunnel is drilled to provide an anatomic location intra-articularly and exit the femur just posterior and proximal to the lateral epicondyle. The additional length of gracilis therefore exits the femoral tunnel at the anatomic origin of the ALL and is then routed (under the iliotibial band) through a tibial tunnel, and back to the femoral origin, to reconstruct the ALL. Alternatives: A large number of different types of non- anatomic LET have been reported. The most frequently performed were the Lemaire and MacIntosh procedures but these, and others, were widely abandoned after reports of poor results in the 1980’s. Rationale: ALL reconstruction differs from other lateral extra-articular tenodesis type procedures by virtue of the fact that the procedure is anatomically based and can be percutaneously performed. Nonanatomical procedures (typically with a strand of ITB passed under the LCL) are associated with reports of overconstraint, early arthritis and an increased risk of infection. In contrast, ALLR has been shown to restore normal knee kinematics and avoid overconstraint, when correctly fixed in full extension and neutral rotation. The main concern with any type of LET is based on historical reports of poor outcomes. However, contemporary study demonstrates that combined ACL and ALLR is associated with a re-operation rate that is comparable to the rate seen after isolated ACLR, and a very low rate of complications. This makes a compelling argument for anatomic ALL+ACLR being considered as the procedure of choice when considering an extra-articular procedure. This is further supported by the fact that even though previous studies have demonstrated a trend to reduced ACL graft rupture with non anatomic LETs they have not shown a statistically significant improvement in outcomes. Combined ACL and ALLR is currently the only type of lateral extra- articular procedure that has been demonstrated to significantly reduce ACL graft rupture risk and improve return to sport

Technical considerations in lateral extra-articular reconstruction coupled with anterior cruciate ligament reconstruction: a simulation study evaluating the influence of surgical parameters on control of knee stability

Background: Surgical parameters such as the selection of tibial and femoral attachment site, graft tension, and knee flexion angle at the time of fixation may influence the control of knee stability after lateral extra-articular reconstruction. This study aimed to determine how sensitive is the control of knee rotation and translation, during simulated pivot-shift scenarios, to these four surgery settings. Methods: A computer model was used to simulate 625 lateral extra-articular reconstructions based upon five different variations of each of the following parameters: femoral and tibial attachment sites, knee flexion angle and graft tension at the time of fixation. For each simulated surgery, the lateral extra-articular reconstruction external rotation moment at the knee joint center was computed during simulated pivot-shift scenarios. The sensitivity of the control of knee rotation and translation to a given surgery setting was assessed by calculating the coefficient of variation of the lateral extra-articular reconstruction external rotation moment. Findings: Graft tension had minimal influence on the control of knee rotation and translation with less than 2.4% of variation across the scenarios tested. Control of knee rotation and translation was the least affected by the femoral attachment site if the knee was close to full extension at the time of graft fixation. The choice of the tibial attachment site was crucial when the femoral fixation was proximal and posterior to the femoral epicondyle since 15 to 67% of variation was observed in the control of knee rotation and translation. Interpretation: Femoral and tibial attachment sites as well as knee flexion angle at the time of fixation should be considered by surgeons when performing lateral extra-articular reconstruction. Variation in graft tension between the ranges 20–40 N has minimal influence on the control of knee rotation and translation

European Consensus on the Management of Sensitized Kidney Transplant Recipients:A Delphi Study

An increasing number of sensitized patients awaiting transplantation face limited options, leading to fatalities during dialysis and higher costs. The absence of established evidence highlights the need for collaborative consensus. Donor-specific antibodies (DSA)-triggered antibody-mediated rejection (AMR) significantly contributes to kidney graft failure, especially in sensitized patients. The European Society for Organ Transplantation (ESOT) launched the ENGAGE initiative, categorizing sensitized candidates by AMR risk to improve patient care. A systematic review assessed induction and maintenance regimens as well as antibody removal strategies, with statements subjected to the Delphi methodology. A Likert-scale survey was distributed to 53 European experts (Nephrologists, Transplant surgeons and Immunologists) with experience in kidney transplant recipient care. A rate ≥75% with the same answer was considered consensus. Consensus was achieved in 95.3% of statements. While most recommendations aligned, two statements related to complement inhibitors for AMR prophylaxis lacked consensus. The ENGAGE consensus presents contemporary recommendations for desensitization and immunomodulation strategies, grounded in predefined risk categories. The adoption of tailored, patient-specific measures is anticipated to streamline the care of sensitized recipients undergoing renal allografts. While this approach holds the promise of enhancing transplant accessibility and fostering long-term success in transplantation outcomes, its efficacy will need to be assessed through dedicated studies.</p

The popliteus tendon provides a safe and reliable location for all-inside meniscal repair device placement

Background: Tears of the posterior horn of the lateral meniscus are challenging to repair because, in contrast to medial meniscal repairs, the capsule and its attachment are thin. Purpose: To evaluate the clinical results of an arthroscopic all-inside repair technique for unstable, vertical, lateral meniscus tears, using a suture anchor device placed directly into the popliteus tendon. Study Design: Case Series; Level of evidence, 4. Methods: A retrospective analysis of prospectively collected data from the ***** database was performed. All patients who had undergone combined ACL reconstruction with lateral meniscus all-inside repair, using sutures placed in the popliteus tendon, between January 2011 and February 2015, were included. At final follow-up, all patients were contacted by telephone to identify if they underwent further surgery or had pain, locking or effusion. Symptomatic patients were recalled for clinical/imaging evaluation. Operative notes for those undergoing further surgery were reviewed and rates and type of re-operation, including for failed lateral meniscal repair were recorded. Results: Two hundred patients (mean age, 28.6 ± 10.2 years) with a mean follow-up of 45.5 ± 12.8 months (range, 24.7-75.2) were included. The mean Subjective International Knee Documentation Committee (IKDC) at final follow-up was 85.0 ± 11.3. The post-operative mean side-to-side laxity measured at one year was 0.6 ± 1.0 mm. Twenty-six patients underwent re-operation (13%) at a mean follow-up of 14.8 ± 7.8 months. The ACL graft rupture rate was 5.0%. Other causes for re-operation included medial meniscus tear (2.5%), cyclops lesion (1.5%) and septic arthritis (0.5%). The lateral meniscus repair failure rate was 3.5%. No specific complications relating to placement of suture anchors in the popliteusn tendon were identified. Conclusion: Arthroscopic all-inside repair of unstable, vertical, lateral meniscal tears using a suture anchor placed in the popliteus tendon is a safe, efficient and reproducible technique. It is associated with a very low failure rate without specific complications

Combined anterior cruciate and anterolateral ligament reconstruction in the professional athlete: clinical outcomes from the SANTI Group in a series of seventy patients with a minimum follow up of two years

Purpose: To evaluate clinical outcomes in professional athletes after combined anterior cruciate ligament (ACL) and anterolateral ligament (ALL) reconstruction, with a minimum follow-up of two years. Methods: All professional athletes who underwent primary combined ACL and ALL reconstruction between January 2011 and March 2016 were included. A retrospective analysis of prospectively collected data from the SANTI Study Group database was performed. Patient assessment included physical examination, pre- and postoperative subjective and objective IKDC, Tegner activity scale (TAS) and Lysholm score. Results: 72 professional athletes underwent primary ACL and ALL reconstruction, 70 (97%) were available with a mean follow-up of 3.9 years (range 2-7). The pre-operative side-to-side anteroposterior laxity difference was 7.1 ± 1.4mm and this decreased significantly after surgery to 0.40.9mm (p<0.0001). Pivot-shift grade evolved from 16 grade I (22.8%) and 54 grade II or III (77.2%) preoperatively, to 66 absent pivot shift (94.3%) and 4 grade I (5.7). By one-year post-operatively, sixty athletes (85.7%) returned to professional sport with a mean time interval of 7.9 months (range 5-12). At final follow up the mean subjective IKDC was 90.5 ± 7.6, Lysholm score 94.4 ± 7.5, Tegner 8.8 ± 1.5. 11 Patients (15,7%) underwent a subsequent ipsilateral re-operation including 4 (5.7%) revision ACL reconstructions. Subgroup analysis of early graft failures (within one year or 3 months of first match post-operatively) in professional soccer players demonstrated a significantly lower rate in the current series (0%) when compared against published rates (7%), chi2 8.457 p=0.0036. Conclusions: Combined ACL and ALL reconstruction is associated with excellent outcomes in professional athletes with respect to graft rupture rates, return to sport, knee stability, and re-operation rates after injury. Subgroup analysis in professional soccer players demonstrates that combined ACL and ALL reconstruction is associated with significantly reduced graft rupture rates when compared to isolated ACL reconstruction. Level of evidence: Level IV case series