Vertical copy camera system provides photographs from ERTS-1 imagery

Versatility of commercially-available camera system permits wide range of enlargement (up to 10X) and reduction (down to 1/8) to be achieved with standard lenses. Use of easily interchangeable camera backs permits photographic formats from 35 mm to 10.2 X 12.7 cm (4 x 5 in) and permits easy use of black and white and color films and Polaroid materials

Synthesizing Photorealistic Virtual Humans Through Cross-modal Disentanglement

Over the last few decades, many aspects of human life have been enhanced with virtual domains, from the advent of digital assistants such as Amazon's Alexa and Apple's Siri to the latest metaverse efforts of the rebranded Meta. These trends underscore the importance of generating photorealistic visual depictions of humans. This has led to the rapid growth of so-called deepfake and talking-head generation methods in recent years. Despite their impressive results and popularity, they usually lack certain qualitative aspects such as texture quality, lips synchronization, or resolution, and practical aspects such as the ability to run in real-time. To allow for virtual human avatars to be used in practical scenarios, we propose an end-to-end framework for synthesizing high-quality virtual human faces capable of speaking with accurate lip motion with a special emphasis on performance. We introduce a novel network utilizing visemes as an intermediate audio representation and a novel data augmentation strategy employing a hierarchical image synthesis approach that allows disentanglement of the different modalities used to control the global head motion. Our method runs in real-time, and is able to deliver superior results compared to the current state-of-the-art

Left Extended Hemihepatectomy With Preservation of Large Inferior Right Hepatic Vein: A Case Report

For hepatic function to be preserved after an extended hemihepatectomy adequate venous drainage of the remaining liver is required. Most metastases close to the confluence of the superior hepatic veins are considered unresectable because hepatic venous outflow after resection would be compromised. In 10–25% of people, the inferior right hepatic vein is of large calibre. Thus the superior hepatic veins may be sacrificed and hepatic function preserved if a large inferior right hepatic vein is present

Electrolytic ablation of the rat pancreas: a feasibility trial

BACKGROUND: Pancreatic cancer is a biologically aggressive disease with less than 20% of patients suitable for a "curative" surgical resection. This, combined with the poor 5-year survival indicates that effective palliative methods for symptom relief are required. Currently there are no ablative techniques to treat pancreatic cancer in clinical use. Tissue electrolysis is the delivery of a direct current between an anode and cathode to induce localised necrosis. Electrolysis has been shown to be safe and reliable in producing hepatic tissue and tumour ablation in animal models and in a limited number of patients. This study investigates the feasibility of using electrolysis to produce localised pancreatic necrosis in a healthy rat model. METHOD: Ten rats were studied in total. Eight rats were treated with variable "doses" of coulombs, and the systemic and local effects were assessed; 2 rats were used as controls. RESULTS: Seven rats tolerated the procedure well without morbidity or mortality, and one died immediately post procedure. One control rat died on induction of anaesthesia. Serum amylase and glucose were not significantly affected. CONCLUSION: Electrolysis in the rat pancreas produced localised necrosis and appears both safe, and reproducible. This novel technique could offer significant advantages for patients with unresectable pancreatic tumours. The next stage of the study is to assess pancreatic electrolysis in a pig model, prior to human pilot studies

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors1,2, yet the relevant antigens remain unknown. Here we use genetic, immunohistochemical and transcriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell antigens in long-term survivors of pancreatic cancer. Using whole-exome sequencing and in silico neoantigen prediction, we found that tumours with both the highest neoantigen number and the most abundant CD8+ T-cell infiltrates, but neither alone, stratified patients with the longest survival. Investigating the specific neoantigen qualities promoting T-cell activation in long-term survivors, we discovered that these individuals were enriched in neoantigen qualities defined by a fitness model, and neoantigens in the tumour antigen MUC16 (also known as CA125). A neoantigen quality fitness model conferring greater immunogenicity to neoantigens with differential presentation and homology to infectious disease-derived peptides identified long-term survivors in two independent datasets, whereas a neoantigen quantity model ascribing greater immunogenicity to increasing neoantigen number alone did not. We detected intratumoural and lasting circulating T-cell reactivity to both high-quality and MUC16 neoantigens in long-term survivors of pancreatic cancer, including clones with specificity to both high-quality neoantigens and predicted cross-reactive microbial epitopes, consistent with neoantigen molecular mimicry. Notably, we observed selective loss of high-quality and MUC16 neoantigenic clones on metastatic progression, suggesting neoantigen immunoediting. Our results identify neoantigens with unique qualities as T-cell targets in pancreatic ductal adenocarcinoma. More broadly, we identify neoantigen quality as a biomarker for immunogenic tumours that may guide the application of immunotherapies

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Background and aims: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress and novel therapeutic response in PC to develop a biomarker driven therapeutic strategy targeting DDR and replication stress in PC. Methods: We interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel PC patient-derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient derived xenografts and human PC organoids. Results: Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors including previously described molecular subtypes. Biomarkers of DDR deficiency, including a novel signature of homologous recombination deficiency, co-segregates with response to platinum (P < 0.001) and PARP inhibitor therapy (P < 0.001) in vitro and in vivo. We generated a novel signature of replication stress with which predicts response to ATR (P < 0.018) and WEE1 inhibitor (P < 0.029) treatment in both cell lines and human PC organoids. Replication stress was enriched in the squamous subtype of PC (P < 0.001) but not associated with DDR deficiency. Conclusions: Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR proficient PC, and post-platinum therapy

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups of PanNETs, termed T1, T2 and T3, with distinct patterns of methylation. The T1 subgroup was enriched for functional tumors and ATRX, DAXX and MEN1 wild-type genotypes. The T2 subgroup contained tumors with mutations in ATRX, DAXX and MEN1 and recurrent patterns of chromosomal losses in half of the genome with no association between regions with recurrent loss and methylation levels. T2 tumors were larger and had lower methylation in the MGMT gene body, which showed positive correlation with gene expression. The T3 subgroup harboured mutations in MEN1 with recurrent loss of chromosome 11, was enriched for grade G1 tumors and showed histological parameters associated with better prognosis. Our results suggest a role for methylation in both driving tumorigenesis and potentially stratifying prognosis in PanNETs

Complex Monitoring of the Vehicle Movement and Technical State

V rámci této bakalářské práce jsem analyzoval a navrhl systém na komplexní monitorování technického stavu a pohybu vozidel - Fleet Management. Dále jsem implementoval prototyp serverové části systému. Zadavatelem tématu této práce je firma Telematix. Moje bakalářská práce se zabývá analýzou konkurenčních systémů, dále robustním návrhem celého systému, který vyhovuje všem požadavkům zadavatele a následně prototypovou implementací serverové části systému. Výsledek mojí práce bude sloužit jako podklad pro vytvoření rozsáhlého systému na monitorování vozidel ve zmiňované firmě.In this thesis I analyzed and designed a complex system for monitoring the technical condition and the movement of vehicles - Fleet Management. Furthermore, I have implemented a prototype server part of the system. The project owner of the topic of this work is Telematix company. My thesis deals with the analysis of competitive systems, further robust design of the entire system which meets all requirements of the project owner and then a prototype implementation of the server. The result of my work will serve as a basis for the creation of an extensive system for monitoring vehicles in the mentioned company

Aetiology of tumour cell movement during laparoscopic surgery : patterns of movement and influencing factors / by Michael Lutz Texler

Accompanying CD-ROM contains image files and software.Bibliography: leaves 259-286.xvi, 286 leavesExplores the factors affecting the movement of tumour cells from a primary malignancy across the peritoneal cavity to the port-site following laparoscopic intervention. Filter methods and radio-labelled tumour cells provided the most useful way of following cell movement. Concludes spread of tumour cells to the port-site is more likely in the presence of disseminated disease, as well as with inappropriate surgical technique. Metastasis may be reduced by the use of intraperitoneal lavage and appropriate surgical technique.Thesis (M.D) -- University of Adelaide, Dept. of Surgery, 199