Influence of Oxygen at Atmospheric and High Pressure on the Developing Tooth Germ in Rat Embryos

Repeated exposure of pregnant rats to oxygen at high pressure (65 psi) twice a day for seven days increased the height of the tooth germ and ameloblastic layer of the embryo, but the width and odontoblastic layer were not changed. Exposure of pregnant rats to oxygen at atmospheric pressure stimulated the body growth of the embryo in utero.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68256/2/10.1177_00220345720510052501.pd

Differences in growth pattern of bone and incisor of rats exposed to O2 atmospheric and high pressure

Three groups of young rats (age 22 days) were exposed intermittently (49 times), over a period of 44 days, group 1 to O2 at atmospheric pressure (OAP), group 2 to O2 at high pressure (OHP) (60 psig) and the third to air at atmospheric pressure (AAP) as controls. The average food consumption for the AAP group was 18.85 g, for the OAP 17.55 g and for the OHP 17.07 g per rat per day. The change in the body weights of each of these groups was followed throughout the experiment which continued 13 days after the last exposures. Bone growth of the maxilla, mandible and femur diaphysis and incisor growth were not altered by the OAP exposures, but were decreased by the OHP exposures; incisor growth, however, was increased. Hardness of the bone (by Tukon Hardness Tester) was increased in the OAP and OHP exposures as compared with that of the AAP, but the hardness of the incisors was not altered.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34114/1/0000398.pd

ACCURACY IN DETERMINING KINETIC PARAMETERS WITH FORCE PLATES EMBEDDED UNDER SOIL-FILLED BASEBALL MOUND

We developed a force measurement system embedded in a soil-filled mound for measuring ground reaction forces (GRF) acting on baseball pitchers and examined the accuracy of determining the point of force application (PFA) and kinetic parameters computed from GRF. Three 1.0 x 0.9 m2 force platforms were placed on the concrete foundation of an indoor sports facility and three bays were fixed onto the aluminum plates of the force plateorms. In each tray, clay-blocks were laid tightly and a mixture of red sand and volcanic-ash was used to make a smooth surface layer. The mean absolute error was 6.0 f 4.0 mm in determining PFA, less than 15.5 Ns (5% of the true value) in determining linear impulse. These results suggest that the present method is valid for measuring the PFA and GRF acting on the pitcher's legs for analyzing kinetics of pitching performances

Guideline on the use of new anticancer drugs for the treatment of Hepatocellular Carcinoma 2010 update

The "Guideline on the Use of New Anticancer Drugs for the Treatment of Hepatocellular Carcinoma" was prepared by the Study Group on New Liver Cancer Therapies established by the "Research Project on Emergency Measures to Overcome Hepatitis" under the auspices of the Health and Labour Sciences Research Grant. The Guideline brings together data collected by the Study Group on the use and incidence of adverse events in 264 patients with advanced hepatocellular carcinoma (HCC) treated using sorafenib and in 535 patients with advanced HCC treated using miriplatin at 16 participating institutions up until 22 December 2010, as well as referring to the published studies, academic presentations, and reports from the private sector. The aim of this Guideline is to facilitate understanding and current thinking regarding the proper usage of new anticancer drugs towards actual use in therapy. In terms of the format, the Guideline presents "clinical questions" on issues pertaining to medical care, makes "recommendations" on diagnosis and treatment in response to each of these clinical questions, and provides a rationale for these recommendations in the form of "scientific statements". © 2012 The Japan Society of Hepatology

Magnetic Fields toward Ophiuchus-B Derived from SCUBA-2 Polarization Measurements

We present the results of dust emission polarization measurements of Ophiuchus-B (Oph-B) carried out using the Submillimetre Common-User Bolometer Array 2 (SCUBA-2) camera with its associated polarimeter (POL-2) on the James Clerk Maxwell Telescope in Hawaii. This work is part of the B-fields in Star-forming Region Observations survey initiated to understand the role of magnetic fields in star formation for nearby star-forming molecular clouds. We present a first look at the geometry and strength of magnetic fields in Oph-B. The field geometry is traced over ~0.2 pc, with clear detection of both of the sub-clumps of Oph-B. The field pattern appears significantly disordered in sub-clump Oph-B1. The field geometry in Oph-B2 is more ordered, with a tendency to be along the major axis of the clump, parallel to the filamentary structure within which it lies. The degree of polarization decreases systematically toward the dense core material in the two sub-clumps. The field lines in the lower density material along the periphery are smoothly joined to the large-scale magnetic fields probed by NIR polarization observations. We estimated a magnetic field strength of 630 ± 410 μG in the Oph-B2 sub-clump using a Davis–Chandrasekhar–Fermi analysis. With this magnetic field strength, we find a mass-to-flux ratio λ = 1.6 ± 1.1, which suggests that the Oph-B2 clump is slightly magnetically supercritical

A Laboratory Study of Alginate Impressions

Master of ScienceProsthodonticshttps://deepblue.lib.umich.edu/bitstream/2027.42/147956/1/ot_013.pd

Growth of the Tooth Germ in Newborn Rats Exposed to Oxygen at Atmospheric and High Pressure

Newborn rats were exposed intermittently to oxygen at high pressure (93 psig) 15 times for a period of eight days. Growth of the tooth germs was the same as that of the control rats in air at atmospheric pressure, with the exception of the enamel and dentin layers, which grew less. The width of the tooth germ of rats exposed to oxygen at atmospheric pressure increased.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67876/2/10.1177_00220345730520033001.pd

The Contrasting Effects between Caffeine and Theobromine on Crystallization: How the Non-fluoride Dentifrice Was Developed

Caffeine and theobromine are members of the xanthine family. Coffee and soft drinks contain caffeine, whereas, in cacao, theobromine is the main ingredient. The mineral contents of the tooth which sucked the caffeine-containing dam’s milk were decreased. To determine if caffeine would affect enamel, dams were fed with a caffeine and pups were killed and first and second molars were extracted. Enamel was exposed to the acid solution and dissolved minerals from the enamel were measured. Calcium, phosphorus and magnesium from the first molars of the caffeine group were significantly dissolved. To determine why minerals were released, enamel was separated. The crystallite size of the enamel from the caffeine group showed decreased. If the pups with the same dietary regimen, but given a cariogenic diet, the caffeine group should show a higher incidence of dental caries. The caffeine group revealed higher caries scores. An in vitro experiment to grow apatite crystals was conducted, adding the various members of the xanthine. Theobromine produced larger crystal sizes than caffeine. Theobromine was added to the maternal diet. Dissolution experiments revealed that these minerals were far less dissolved. Comparative studies of the various parameters between theobromine and fluoride were conducted. Theobromine was superior to fluoride in every aspect