Przypadek 65-letniej chorej na czerniaka w stadium rozsiewu wieloogniskowego leczonej pembrolizumabem

Niniejsze opracowanie przedstawia przypadek 65-letniej pacjentki, u której w 2013 roku zdiagnozowano czerniaka skóry w stadium zlokalizowanym. W lipcu 2016 roku stwierdzono następnie rozsiew choroby do płuc, brzucha oraz ośrodkowego układu nerwowego. Chora została zakwalifikowana do leczenia przeciwciałami anty-PD1 i w październiku 2016 roku otrzymała pierwszy wlew pembrolizumabu. W wyniku leczenia osiągnięto częściową remisję wszystkich opisywanych wcześniej zmian. Pacjentka w dalszym ciągu jest w trakcie leczenia. Niniejsza praca obrazuje aktywność pembrolizumabu w przypadku rozsiewu czerniaka do ośrodkowego układu nerwowego, niemniej jednak leczenie w takich przypadkach pozostaje wyzwaniem

Przekształcenia konwersyjne form architektury sakralnej pogranicza po II wojnie światowej na przykładzie wybranych świątyń poewangelickich

Предметом исследования является архитектурное переустройство евангелических храмов, расположенных на территории Вармии и Мазур. Цель исследования – представление главных изменений, возникающих в архитектуре храмов в результате их конверсии и отражающих различие между реформаторскими и римско-католическими святынями. Статья является попыткой ответить на вопрос – возможно ли использование сакральных объектов представителями различных вероисповеданий христианства при уважении к особенностям каждой из конфессий? Как далеко могут заходить перестройки, происходящие при конверсии храмов

Deposition of Zinc Oxide on the Materials Used in Medicine. Preliminary Results

This paper presents preliminary results of the direct deposition of nano- and microstructures of zinc oxide on materials used in medicine. The coatings were deposited on cotton gauze and polyamide fabric. During the research the biological activity of these materials was defined. Performed were also tests of doping the ZnO structures with silver obtained. The research has proved that there is a growth of zinc oxide structures both on the gauze and polyamide fabric. The nanostructures deposited on it did not become detached from the surface, even though the material was subjected to ultrasonic rinsing. In addition, good biocidal properties of both of the textile materials modified were found. Furthermore a complex surface analysis of catheters: vascular and urological was made. ZnO was deposited on catheters, but they were characterised by low adhesion

Kobiety z warstwy rycerskiej w świetle dokumentów mazowieckich z XII i XIII wieku

The article poses the question of the legal status of a woman of the knightly class in the 12th and 13th centuries in Masovia. Due to the scarcity of source materials, studies on the subject have been undertaken so far in a very limited scope. An analysis was conducted of ten documents that were drawn up in Masovia or issued by Masovian dukes in which women are mentioned during the period under discussion. They appeared in the documents most often together with their husbands or as widows granting charters mainly for the benefit of the Church. It is interesting to note that women mentioned in the documents, made property dispositions either together with their husbands or by themselves and the grants were made for the benefit of ecclesiastical institutions. The women who were mentioned in the article appeared in the documents, in most cases, made grants by themselves. In two instances, women were mentioned in their husbands’ documents. In one instance, as many as three documents concern the case where a woman was involved. As a matter of fact, all the women except for one were mentioned by their names. In light of known documents, it should be concluded that during the period of feudal fragmentation in the province of Masovia women had the possibility of disposing of their property and their property rights were recognized. However, what is noticeable is that the number of documents from Masovia in which dispositions of property were made by women, is much smaller as compared to the number of documents coming from other parts of Poland.W artykule postawiono pytanie, jaka była pozycja prawna kobiety z warstwy rycerskiej w XII i XIII wieku na Mazowszu. Tego typu badania, ze względu na słabą podstawę źródłową, były dotąd podejmowane w znikomym stopniu. Przeprowadzono analizę 10 dokumentów powstałych na Mazowszu lub wystawionych przez władców rządzących Mazowszem w wyżej wskazanym czasie, w których wzmiankowane są kobiety. Występowały one w nich najczęściej z mężami lub jako wdowy, dokonując nadań na rzecz Kościoła. Wymienione w artykule kobiety pojawiały się w dokumentach, w większości przypadków czyniąc nadania samodzielnie. W dwóch przypadkach zostały wspomniane w dokumentach swoich mężów. W jednym przypadku sprawy, w którą zaangażowana była kobieta, dotyczą aż trzy dokumenty. Właściwie wszystkie kobiety, z wyjątkiem jednego dokumentu, zostały wymienione z imienia. W świetle znanych dokumentów należy stwierdzić fakt uznawania praw kobiet do własności majątkowej i możliwości rozporządzania nią w dzielnicy mazowieckiej w okresie rozbicia dzielnicowego, uwagę zwraca natomiast bardzo mała ilość dokumentów, w których dyspozycje majątkowe czyniły kobiety, szczególnie w stosunku do sytuacji na innych ziemiach polskich

Oxidation of Hydrocarbons on the Surface of Tin Dioxide Chemical Sensors

The paper presents the results of our investigation on the effect of the molecular structure of organic vapors on the characteristics of resistive chemical gas sensors. The sensors were based on tin dioxide and prepared by means of thick film technology. The electrical and catalytic examinations showed that the abstraction of two hydrogen atoms from the organic molecule and formation of a water in result of reaction with a chemisorbed oxygen ion, determine the rate of oxidation reactions, and thus the sensor performance. The rate of the process depends on the order of carbon atoms and Lewis acidity of the molecule. Therefore, any modification of the surface centers of a sensor material, modifies not only the sensor sensitivity, but also its selectivity

Value of planar lymphoscintigraphy (PL) versus SPECT/CT in evaluation of sentinel lymph node in trunk melanoma — one center, large series retrospective study

BACKGROUND: Localization and histopathological examination of sentinel lymph node is a standard of melanoma treatment. The first stage of identification of the SLN is the preoperative lymphoscintigraphy. The aim of this study was to assess and compare diagnostic value of planar lymphoscintigraphy and SPECT/CT in sentinel lymph node biopsy procedure performed in patients with cutaneous trunk melanoma. MATERIAL AND METHODS: Between 2015 and 2016, patients with trunk melanoma (N = 255, F/M 95/160), aged from 17 to 88 after an excisional biopsy, with primary tumor ≥ pT1b (AJCC 2009, median Breslow thickness 2.0 ± 3.13) were included in the study. In all the patients PL was followed by SPECT/CT 1–3 hours after injection of 99mTc- colloid particles, and SLNB was performed the next day. RESULTS: SPECT-CT revealed 78 (18.6%) SLN more than PL, and in 40 patients showed additional lymph drainage regions leading to surgical adjustments. In 18 patients (7.1%) SPECT-CT revealed SLN not visible in the PL (false-negative PL) and in 22 patients (8.6%), foci of uptake interpreted in PL as hot SLNs were found to be non-nodal sites of uptake when assessed on SPECT/CT (false positive PL). SPECT-CT vs. PL mismatch was observed in 31 patients (12.2%) and was the most common in patients with primary lesions located in the anterior inferior medial region (75%). CONCLUSIONS: Results of the presented study indicates the high diagnostic value of SPECT-CT in assessment of SLNs and proved that SPECT-CT increases the sensitivity and accuracy of SLN identification as compared to PL even in very experienced hands