An interpolation theorem between one-sided Hardy spaces

In this paper we generalize an interpolation result due to J.-O. Strömberg and A. Torchinsky to the case of one-sided Hardy spaces. This generalization is important in the study of the weak type (1,1) for lateral strongly singular operators. We shall need an atomic decomposition in which for every atom there exists another atom supported contiguously at its right. In order to obtain this decomposition we have developed a rather simple technique to break up an atom into a sum of others atoms. © 2006 by Institut Mittag-Leffler. All rights reserved.Fil:Ombrosi, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Testoni, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina

A choice of Sobolev spaces associated with ultraspherical expansions

We discuss two possible definitions for Sobolev spaces associated with ultraspherical expansions. These definitions depend on the notion of higher order derivative. We show that in order to have an isomorphism between Sobolev and potential spaces, the higher order derivatives to be considered are not the iteration of the first order derivatives. Some discussions about higher order Riesz transforms are involved. Also we prove that the maximal operator for the Poisson integral in the ultraspherical setting is bounded on the Sobolev spaces

Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease. Although genetic predisposition and epigenetic factors contribute to the development of NAFLD, our understanding of the molecular mechanism involved in the pathogenesis of the disease is still emerging. Here we investigated a possible role of a microRNAs-STAT3 pathway in the induction of hepatic steatosis. Differentiated HepaRG cells treated with the fatty acid sodium oleate (fatty dHepaRG) recapitulated features of liver vesicular steatosis and activated a cell-autonomous inflammatory response, inducing STAT3-Tyrosine-phosphorylation. With a genome-wide approach (Chromatin Immunoprecipitation Sequencing), many phospho-STAT3 binding sites were identified in fatty dHepaRG cells and several STAT3 and/or NAFLD-regulated microRNAs showed increased expression levels, including miR-21. Innovative CARS (Coherent Anti-Stokes Raman Scattering) microscopy revealed that chemical inhibition of STAT3 activity decreased lipid accumulation and deregulated STAT3-responsive microRNAs, including miR-21, in lipid overloaded dHepaRG cells. We were able to show in vivo that reducing phospho-STAT3-miR-21 levels in C57/BL6 mice liver, by long-term treatment with metformin, protected mice from aging-dependent hepatic vesicular steatosis. Our results identified a microRNAs-phosphoSTAT3 pathway involved in the development of hepatic steatosis, which may represent a molecular marker for both diagnosis and therapeutic targeting

Systemic sclerosis cutaneous expression: Management of skin fibrosis and digital ulcers

Systemic sclerosis is a connective tissue disease with cutaneous involvement. Clinical manifestations result from the balance of inflammations/autoimmunity process and fibrogenesis. Patients suffer from skin ulcers, non-ulcerative lesions including digital pitting scars, telangiectasias, subungual hyperkeratosis, abrasions, fissures, and subcutaneous calcinosis. A review about the pathophysiology of the disease, the physical examination of the patients, the instrumental assessment, and possible treatments is performed

Information Literacy Needs Open Access or: Open Access is not Only for Researchers

The Open Access was initially (blandly) conceived in view not only of researchers but also of lay readers, then this perspective slowly faded out. The Information Literacy movement wants to teach citizens how to arrive at trustable information but the amount of paywalled knowledge is still big. So, their lines of development are somehow complementary: Information Literacy needs Open Access for the citizens to freely access high quality information while Open Access truly fulfils its scope when it is conceived and realized not only for the researchers (an aristocratic view which was the initial one) but for the whole society