Simulating peculiar X-shaped extragalactic radio sources

Peculiar morphologies have been observed among extragalactic radio sources, which present important sideways features that are yet to be explained. After obtaining the region in the parameter space for which the intended lateral extensions appear, further 2D simulations using PLUTO code were performed. For some selected sets of parameters the effect of resolution on the simulated morphology, and the effect of a toroidal magnetic field on the propagation of the simulated jet in the stratified medium, were considered

Young stellar object jet models: From theory to synthetic observations

Astronomical observations, analytical solutions and numerical simulations have provided the building blocks to formulate the current theory of young stellar object jets. Although each approach has made great progress independently, it is only during the last decade that significant efforts are being made to bring the separate pieces together. Building on previous work that combined analytical solutions and numerical simulations, we apply a sophisticated cooling function to incorporate optically thin energy losses in the dynamics. On the one hand, this allows a self-consistent treatment of the jet evolution and on the other, it provides the necessary data to generate synthetic emission maps. Firstly, analytical disk and stellar outflow solutions are properly combined to initialize numerical two-component jet models inside the computational box. Secondly, magneto-hydrodynamical simulations are performed in 2.5D, following properly the ionization and recombination of a maximum of $29$ ions. Finally, the outputs are post-processed to produce artificial observational data. The first two-component jet simulations, based on analytical models, that include ionization and optically thin radiation losses demonstrate promising results for modeling specific young stellar object outflows. The generation of synthetic emission maps provides the link to observations, as well as the necessary feedback for the further improvement of the available models.Comment: accepted for publication A&A, 20 pages, 11 figure

Peculiar morphologies of extended extragalactic radio sources from numerical simulations

Among the extragalactic radio sources there are objects with unusual morphologies. We investigated the possibility that the propagation of jets in a stratified distribution of density may produce such effects. A numerical setup was worked out and hydrodynamical 2D simulations were performed using the PLUTO code. We carried out a parametric study of a jet launched along the main axis of the mass distribution in order to obtain important sideways features

Exploring the multi-humped fission barrier of 238U via sub-barrier photofission

The photofission cross-section of 238U was measured at sub-barrier energies as a function of the gamma-ray energy using, for the first time, a monochromatic, high-brilliance, Compton-backscattered gamma-ray beam. The experiment was performed at the High Intensity gamma-ray Source (HIgS) facility at beam energies between E=4.7 MeV and 6.0 MeV and with ~3% energy resolution. Indications of transmission resonances have been observed at gamma-ray beam energies of E=5.1 MeV and 5.6 MeV with moderate amplitudes. The triple-humped fission barrier parameters of 238U have been determined by fitting EMPIRE-3.1 nuclear reaction code calculations to the experimental photofission cross section.Comment: 5 pages, 3 figure

Nuclear astrophysics measurements with ELISSA at ELI-NP

ELISSA is a new silicon-strip detector array under development at the Extreme Light Infrastructure - Nuclear Physics facility in collaboration with INFN-LNS, Catania. ELI-NP will provide very intense, brilliant gamma beams, tunable from 200keV to 19.5MeV. Several reactions important for the astrophysical p-process, Big Bang Nucleosynthesis and supernova explosion have been selected for the first measurement campaigns starting in 2019

The EMA Assessment of Asciminib for the Treatment of Adult Patients With Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase Who Were Previously Treated With at Least Two Tyrosine Kinase Inhibitors

Asciminib is an allosteric high-affinity tyrosine kinase inhibitor (TKI) of the BCR-ABL1 protein kinase. This kinase is translated from the Philadelphia chromosome in chronic myeloid leukemia (CML). Marketing authorization for asciminib was granted on August 25, 2022 by the European Commission. The approved indication was for patients with Philadelphia chromosome-positive CML in the chronic phase which have previously been treated with at least 2 TKIs. Clinical efficacy and safety of asciminib were evaluated in the open-label, randomized, phase III ASCEMBL study. The primary endpoint of this trial was major molecular response (MMR) rate at 24 weeks. A significant difference in MRR rate was shown between the asciminib treated population and the bosutinib control group (25.5% vs. 13.2%, respectively, P=.029). In the asciminib cohort, adverse reactions of at least grade 3 with an incidence≥5% were thrombocytopenia, neutropenia, increased pancreatic enzymes, hypertension, and anemia. The aim of this article is to summarize the scientific review of the application which led to the positive opinion by the European Medicines Agency's Committee for Medicinal Products for Human Use.</p

Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors

We report on the first measurement of 39Ar in argon from underground natural gas reservoirs. The gas stored in the US National Helium Reserve was found to contain a low level of 39Ar. The ratio of 39Ar to stable argon was found to be <=4x10-17 (84% C.L.), less than 5% the value in atmospheric argon (39Ar/Ar=8x10-16). The total quantity of argon currently stored in the National Helium Reserve is estimated at 1000 tons. 39Ar represents one of the most important backgrounds in argon detectors for WIMP dark matter searches. The findings reported demonstrate the possibility of constructing large multi-ton argon detectors with low radioactivity suitable for WIMP dark matter searches.Comment: 6 pages, 2 figures, 2 table