Detection of delta Scuti-like pulsation in H254, a pre-main sequence F-type star in IC 348

We present time series observations of intermediate mass PMS stars belonging to the young star cluster IC 348. The new data reveal that a young member of the cluster, H254, undergoes periodic light variations with delta Scuti-like characteristics. This occurrence provides an unambiguous evidence confirming the prediction that intermediate-mass pre-main sequence (PMS) stars should experience this transient instability during their approach to the main-sequence. On the basis of the measured frequency f=7.406 c/d, we are able to constrain the intrinsic stellar parameters of H254 by means of linear, non adiabatic, radial pulsation models. The range of the resulting luminosity and effective temperature permitted by the models is narrower than the observational values. In particular, the pulsation analysis allows to derive an independent estimate of the distance to IC 348 of about 320 pc. Further observations could either confirm the monoperiodic nature of H254 or reveal the presence of other frequencies.Comment: 7 pages, including 7 postscript figures, accepted for publication on A&

The GSC-II-based survey of ancient cool white dwarfs I. The sample of spectroscopically confirmed WDs

The GSC-II white dwarf survey was designed to identify faint and high proper motion objects, which we used to define a new and independent sample of cool white dwarfs. With this survey we aim to derive new constraints on the halo white dwarf space density. Also, these data can provide information on the age of thick disk and halo through the analysis of the luminosity function. On the basis of astrometric and photometric parameters, we selected candidates with mu > 0.28 as/yr and R_F > 16 in an area of 1150 square degrees. Then, we separated white dwarfs from late type dwarfs and subdwarfs by means of the reduced proper motion diagram. Finally, spectroscopic follow-up observations were carried out to confirm the white dwarf nature of the selected candidates. We found 41 white dwarfs of which 24 are new discoveries. Here we present the full sample and for each object provide positions, absolute proper motions, photometry, and spectroscopy.Comment: 14 pages, 7 figures, submitted to A&

Potential Nutrigenomic Approaches to Reduce the High Incidence of Obesity in Qatar

Obesity prevalence has been growing exponentially over the last few decades, with a high impact in high-income countries, like Qatar. Several approaches are attempting to understand the causes of this phenomenon however more important is what to do to reverse the trends. Obesity is widely studied, mostly in Europe and the Unites States, and a number of studies have demonstrate the role of specific gene patterns, transcriptome and proteome pathways, and gut microbiome strains. The Omics sciences have a great potential to investigate the determinants of non-communicable diseases, such as obesity. Nutritional genomics sciences apply all the Omics approaches to address nutrition-related diseases, investigating the interaction between genes and diet. To date, few data are available from nutrigenomic studies conducted in Middle East and particularly in Qatar to help the design of targeted interventions. The high incidence of obesity and the peculiar genetic make-up of the Qatari population provide opportunities for exploring nutrigenomic approaches to help addressing the problem

Describing astronomy identity of upper primary and middle school students through structural equation modeling

We describe how young students situate themselves with respect to astronomy through an identity framework that features four dimensions: interest, utility value, confidence, and conceptual knowledge. Overall, about 900 Italian students, from 5th to 9th grade (9-14 years old), were involved in the study. We tested our model using confirmatory factor analysis and structural equation modeling. Differences between girls and boys and across school levels were also investigated. Results show that interest has both a direct and an indirect effect on astronomy identity. The indirect effect of interest on identity is mediated by utility value. Moreover, confidence mediates the effect of interest on conceptual knowledge. Concerning differences between girls and boys, we found that the effect of interest on identity is greater for girls than for boys and that the utility value mediates the effect of interest on identity for boys but not for girls. Finally, our findings show also that the students' interest in astronomy and confidence in their performance decrease with age, with a potential negative impact on conceptual knowledge and future career choice in astronomy. The astronomy identity framework can be employed to examine the role of affective variables on performance and persistence in astronomy and to improve the design of teaching-learning activities that can potentially stimulate a lasting interest in astronomy

A companion candidate in the gap of the T Cha transitional disk

T Cha is a young star surrounded by a cold disk. The presence of a gap within its disk, inferred from fitting to the spectral energy distribution, has suggested on-going planetary formation. We observed T Cha in L' and K_s with NAOS-CONICA, the adaptive optics system at the VLT, using sparse aperture masking. We detected a source in the L' data at a separation of 62+-7 mas, position angle of 78+-1 degrees, and a contrast of delta L' = 5.1+-0.2 mag. The object is not detected in the Ks band data, which show a 3-sigma contrast limit of 5.2 mag at the position of the detected L' source. For a distance of 108 pc, the detected companion candidate is located at 6.7 AU from the primary, well within the disk gap. If T Cha and the companion candidate are bound, the comparison of the L' and Ks photometry with evolutionary tracks shows that the photometry is inconsistent with any unextincted photosphere at the age and distance of T Cha. The detected object shows a very red Ks-L' color for which a possible explanation would be a significant amount of dust around it. This would imply that the companion candidate is young, which would strengthen the case for a physical companion, and moreover that the object would be in the substellar regime, according to the Ks upper limit. Another exciting possibility would be that this companion is a recently formed planet within the disk. Additional observations are mandatory to confirm that the object is bound and to properly characterize it.Comment: 4 pages, 4 figures; accepted for publication by A&

Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients

Calcium-sensing receptor (CaSR) is a plasma membrane protein that regulates tubular reabsorption of Ca. To establish its role in idiopathic hypercalciuria, the association of urinary Ca excretion with the polymorphisms of CASR gene has been studied in healthy subjects and in hypercalciuric and normocalciuric Ca stone formers. CASR exon 7 single nucleotide polymorphisms (SNP), G/T at codon 986, G/A at codon 990, and C/G at codon 1011, were evaluated by PCR amplification and direct sequencing in 97 normocalciuric stone formers, 134 hypercalciuric stone formers, and 101 normocalciuric healthy controls. Four haplotypes were defined on the basis of CASR gene SNP: haplotype 1 was characterized by the most frequent sequence; haplotypes 2, 3, or 4 by the presence of a single polymorphic variant at codon 986, 990, or 1011, respectively. The relative risk of hypercalciuria was calculated with multinomial logistic regression and was significantly increased only in individuals carrying haplotype 3 (Odds ratio, 13.0 [95% confidence interval, 1.7 to 99.4]). Accordingly, Ca excretion was higher in subjects bearing haplotype 3, whereas those bearing haplotype 2 showed a slight increase of plasma Ca concentration. Multiple regression analysis showed that haplotype 3 explained 4.1% of the total variance of Ca excretion and 12.6% of the variance explained by the variables considered in the study. In conclusion, CASR gene could be a component of the complex genetic background regulating Ca excretion. Arg990Gly polymorphism could facilitate activation of CaSR and increase Ca excretion and susceptibility to idiopathic hypercalciuria

Relation between the luminosity of young stellar objects and their circumstellar environment

We present a new model-independent method of comparison of NIR visibility data of YSOs. The method is based on scaling the measured baseline with the YSO's distance and luminosity, which removes the dependence of visibility on these two variables. We use this method to compare all available NIR visibility data and demonstrate that it distinguishes YSOs of luminosity >1000L_sun (low-L) from YSOs of <1000L_sun (high-L). This confirms earlier suggestions, based on fits of image models to the visibility data, for the difference between the NIR sizes of these two luminosity groups. When plotted against the ``scaled'' baseline, the visibility creates the following data clusters: low-L Herbig Ae/Be stars, T Tauri stars, and high-L Herbig Be stars. The T Tau cluster is similar to the low-L Herbig Ae/Be cluster, which has ~7 times smaller ``scaled'' baselines than the high-L Herbig Be cluster. We model the shape and size of clusters with different image models and find that low-L Herbig stars are the best explained by the uniform brightness ring and the halo model, T Tauri stars with the halo model, and high-L Herbig stars with the accretion disk model. However, the plausibility of each model is not well established. Therefore, we try to build a descriptive model of the circumstellar environment consistent with various observed properties of YSOs. We argue that low-L YSOs have optically thick disks with the optically thin inner dust sublimation cavity and an optically thin dusty outflow above the inner disk regions. High-L YSOs have optically thick accretion disks with high accretion rates enabling gas to dominate the NIR emission over dust. Although observations would favor such a description of YSOs, the required dust distribution is not supported by our current understanding of dust dynamics.Comment: 20 pages, 12 figures, Accepted for publication in the Astrophysical Journa

Vaginal microbiota and cytokine levels predict preterm delivery in Asian women

Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. Approximately half of PTBs is linked with microbial etiologies, including pathologic changes to the vaginal microbiota, which vary according to ethnicity. Globally more than 50% of PTBs occur in Asia, but studies of the vaginal microbiome and its association with pregnancy outcomes in Asian women are lacking. This study aimed to longitudinally analyzed the vaginal microbiome and cytokine environment of 18 Karen and Burman pregnant women who delivered preterm and 36 matched controls delivering at full term. Using 16S ribosomal RNA gene sequencing we identified a predictive vaginal microbiota signature for PTB that was detectable as early as the first trimester of pregnancy, characterized by higher levels of Prevotella buccalis, and lower levels of Lactobacillus crispatus and Finegoldia, accompanied by decreased levels of cytokines including IFNgamma, IL-4, and TNFalpha. Differences in the vaginal microbial diversity and local vaginal immune environment were associated with greater risk of preterm birth. Our findings highlight new opportunities to predict PTB in Asian women in low-resource settings who are at highest risk of adverse outcomes from unexpected PTB, as well as in Burman/Karen ethnic minority groups in high-resource regions

Glucagon-like peptide-1 receptor and sarcoglycan delta genetic variants can affect cardiovascular risk in chronic kidney disease patients under hemodialysis

Background Chronic kidney disease (CKD) patients under hemodialysis show a higher risk of cardiovascular (CV) mortality and morbidity than the general population. This study aims to identify genetic markers that could explain the increased CV risk in hemodialysis. Methods A total of 245 CKD patients under hemodialysis were recruited and followed up for 5\u2009years to record CV events. Genetic analysis was performed using single-nucleotide polymorphisms (SNPs) genotyping by Infinium Expanded Multi-Ethnic Genotyping Array (Illumina, San Diego, CA, USA) comparing patients with and without a history of CV events [161 cardiovascular diseases (CVDs) and 84 no CVDs]. The fixation index (Fst) measure was used to identify the most differentiated SNPs, and gene ontology analysis [Protein Analysis THrough Evolutionary Relationships (PANTHER) and Ingenuity Pathway Analysis (IPA)] was applied to define the biological/pathological roles of the associated SNPs. Partitioning tree analysis interrogated the genotype\u2013phenotype relationship between discovered genetic variants and CV phenotypes. Cox regression analysis measured the effect of these SNPs on new CV events during the follow-up (FU). Results Fst analysis identified 3218 SNPs that were significantly different between CVD and no CVD. Gene ontology analysis identified two of these SNPs as involved in cardiovascular disease pathways (Ingenuity Pathway) and heart development (Panther) and belonging to 2 different genes: Glucagon-like peptide-1 receptor (GLP1R) and Sarcoglycan delta (SGCD). The phenotype\u2013genotype analysis found a higher percentage of CVD patients carrying the GLP1R rs10305445 allele A (P\u2009=\u20090.03) and lower percentages of CVD patients carrying the SGCD rs145292439 allele A (P\u2009=\u20090.038). Moreover, SGCD rs145292439 was associated with higher levels of high-density lipoprotein (P\u2009=\u20090.015). Cox analysis confirmed the increased frequency of CV events during the 5-year FU in patients carrying GLP1R rs1035445 allele A but it did not show any significant association with SGCD rs145292439. Conclusions This study identified GLP1R rs10305445 and SCGD rs145292439 as potential genetic markers that may explain the higher risk of CVD in hemodialysis patients