Synthesis and spectral characteristics of 2,2-bis(hydroxymethyl)propionic acid derivatives as model compounds for the estimation of properties of modified hyperbranched polyesters polyols

© 2015 Pleiades Publishing, Ltd. New amino and carboxy derivatives of methyl 2,2-bis(hydroxymethyl)propionate have been synthesized as models of terminal fragments of hyperbranched polyester polyamines and polyesters polycarboxylic acids, and their spectral characteristics have been studied

Маркетинговые методы в работе медицинской библиотеки

Application of marketing approaches in the Scientific Medical Library of the SSMU. The use of additional financial assets for library development. Informational and promotional activities. Library work on the formation and perfection of the image.Внедрение маркетинговых подходов в научно-медицинской библиотеке Сибирского государственного медицинского университета (НМБ СГМУ). Привлечение дополнительных финансовых средств на развитие библиотеки. Информационная и рекламная деятельность. Работа библиотеки по формированию и совершенствованию имиджа

ПРИМЕНЕНИЕ МЕТОДА ГЛАВНЫХ КОМПОНЕНТ ДЛЯ КЛАССИФИКАЦИИ УГЛЕРОД-МИНЕРАЛЬНЫХ МАТЕРИАЛОВ

Sapropels are multilayer deposits accumulating on the bottom of fresh water bodies. They are complex multicomponent systems containing both organic and mineral parts. The wide possibilities of using sapropels cause interest in studying their properties, processing methods and new sapropel-based materials. The specialized Sapropel Committee was established at the beginning of the last century. It carries out a large amount of work related to the study and processing of sapropels. In this paper we study the possibility of applying chemometric algorithms for the classification of carbon-mineral materials obtained by calcination of organic and mineral sapropels in an argon atmosphere, as well as products of acidic, alkali and steam treatment of initial carbon-mineral materials. For the chemometric data processing the principal component analysis is chosen as one of the most widely used chemometrical algorithms. In addition to the direct application, the principal component analysis serves as the basis for a group of other analogous chemometric algorithms. It is based on the decomposition of the initial data matrix into scores and loadings matrixes. In this paper, carbon-mineral materials chemometric classification possibilities by their physicochemical characteristics and elemental composition are studied. It is shown that carbon-mineral materials can be classified by initial sapropel type using any type of incomplete data set as well as data sets of various combinations. Based on the obtained results, it is concluded that it is possible to predict certain characteristics of carbon-mineral materials with use of the principal component analysis from the results of simpler and faster measurements.Keywords: principal component analysis, samples classification, carbon-mineral materials, sapropelDOI: http://dx.doi.org/10.15826/analitika.2018.22.3.002(Russian)E.N.Terekhova1, A.P.Komov2, I.V.Vlasosa21Institute of Hydrocarbons Processing SB RAS Russian Federation, 644040, Omsk, ul. Neftezavodskaya, 542F.M. Dostoevsky Omsk State University, Russian Federation, 644077, Omsk,ul. Mira, 55Сапропели – многослойные отложения, скапливающиеся на дне пресных водоёмов. Они представляют собой сложные многокомпонентные системы, содержащие органическую и минеральную части. Сапропели непрерывно накапливаются в водоёмах. Широкие возможности применения сапропелей вызывают интерес к изучению их свойств, способов обработки и переработки как самих сапропелей, так и полученных на их основе новых материалов. В данной работе изучена возможность хемометрической классификации углерод-минеральных материалов, полученных путем прокаливания в атмосфере аргона сапропелей двух типов – органического и минерального, а также продуктов кислотной, щелочной и паровой обработки исходных углерод-минеральных материалов. Для хемометрической обработки данных в работе использован метод главных компонент – наиболее распространённый хемометрический алгоритм, применяемый не только сам по себе, но и дающий основу ряду других аналогичных методов. Основной принцип данного метода – декомпозиция матрицы исходных данных с получением произведения матриц счетов и нагрузок. В качестве исходных данных для проведения классификации образцов углерод-минеральных материалов и продуктов их переработки использованы физико-химические показатели и данные о содержании ряда элементов в изучаемых образцах. Показано, что при классификации образцов с использованием даже неполного набора данных любого типа, а также их различных комбинаций наблюдается чёткое деление на группы по природе исходного сапропеля. На основании полученных результатов сделан вывод о возможности предсказания некоторых характеристик углерод-минеральных материалов с помощью метода главных компонент по результатам более простых и быстрых измерений.Ключевые слова: метод главных компонент, классификация образцов, углерод-минеральные материалы, сапропельDOI: http://dx.doi.org/10.15826/analitika.2018.22.3.00

Improving the components of health-saving technologies in a modern university

Nowadays, one of the important missions of higher educational institutions is the organisation and introducing students to a culture of health. The purpose of this study is to propose a strategy for the development of health-saving technologies by implementation of project activities into the educational process based on the Physical Education Department at the State University of Management for the formation of competencies in the chosen professional activity. The sociological survey was carried out among students at the State University of Management. The questionnaires included questions on students’ attitudes towards physical culture as an integral component of a healthy lifestyle. The degree of interest of the respondents in project activities in general and on the basis of the Department of Physical Education at the university, in particular, to improve the acquired professional competences was determined. The results of the study point to the need to modernise approaches to the formation of healthy lifestyle values, including the organisation of physical culture events, the development of a marketing plan to attract mass attention to the sports life of the university, where the main role is given to self-education and the realisation of the individual’s potential through active participation in university sporting life

Innovative Methods in Management and Raising the Quality of Higher Professional Education in Russia

Economic and political changes in contemporary society lead to reforms of many social spheres. The system of education in general and higher professional education in particular is no exception. The issue of ensuring the quality of education has recently attracted great attention in all countries of the world. The key problem of reforming education is raising its quality. In this paper, the object of research was the quality of education provided by higher education institutions. The authors have conducted the analysis of models for raising the quality of education and qualimetry of the laboratory work quality based on a survey of teachers and students. The QFD method was described by the example of its application in five universities of the Russian Federation. It has been proved that this method can provide the university with a planning tool with which higher education institutions can provide services that fully meet the requirements of customers (students, parents, employers, the state and society as a whole), thereby ensuring the suitability of the system to meet external requirements – the Fitness-for-Purpose approach (building goals based on the external environment). In addition, it has also been substantiated that the application of this method in the system of higher professional education will ensure the suitability of the system to achieve its own goals - the Fitness-for-Purpose approach (development, improvement, effective management). Thus, the QFD method will make it possible to support of all types of coordinated activities for the leadership and management of higher education institutions in relation to quality, as well as a set of developed regulatory and methodological documents that determine the content, technologies, methods and means of work of all officials, teachers and students to further improve the quality of educational process, thereby ensuring the competitiveness of higher education institutions and effective development on the global market of educational service

Synthesis and Antimicrobial Activity of New Dialkyl(diaryl)-2-(5-chloro-2-hydroxyphenyl)-2-(phenylethenyl)pentylphosphonium Salts

© 2018, Pleiades Publishing, Ltd. New dialkyl(diaryl)-2-(5-chloro-2-hydroxyphenyl)-2-(phenylethenyl)pentylphosphonium salts bearing various substituents at the phosphorus atom were synthesized. Antimicrobial activity of the salts obtained was estimated. Derivatives with 2-methoxyphenyl substituents at the phosphorus atom are most active against grampositive bacteria. Herewith, dibenzyl-substituted phosphonium derivatives possess the best antifungal activity

Effect of CFP-10/ESAT-6 secretory proteins on long-term non-specific immunological memory in mouse macrophages

Innate immune cells (monocytes/macrophages, NK) can also develop immune memory, which means that these cells are trained after their first encounter with pathogens so that they exhibit a nonspecific immunological response to the same or another pathogen. Bacilli Calmette–Gu rin (BCG) induces nonspecific innate memory (trained immunity) in innate immune cells. We examined nonspecific innate memory in macrophages of BALB/c mice in response to mycobacteria with or without the RD1 region in the genome. Mice were immunized with BCG vaccine, and peritoneal macrophages were isolated on day 7, and then stimulated with bacterial lipopolysaccharide, CFP-10, or ESAT-6. In addition, mice were immunized with Mycobacterium tuberculosis uro-BCG vaccine (RD1-) and Mycobacterium tuberculosis strain H37Rv (RD1+) subcutaneously or intravenously; peritoneal macrophages were isolated and stimulated with lipopolysaccharide on day 4. Alveolar macrophages were obtained from lung explants of mice infected with Mycobacterium tuberculosis strain H37Rv mice, were expanded to confluence 70-80% and further stimulated with lipopolysaccharide. Lactate, cytokines, and glucose levels were examined in conditioned macrophage medium. Peritoneal macrophages from mice primed with BCG vaccine were shown to increase IL-1b, TNFa, and lactate production in response to CFP-6 and ESAT-10 (p < 0.05). Of note is the fact that lipopolysaccharide also increased production of IL-1b, TNFa, and also increased glucose uptake by peritoneal macrophages primed with BCG vaccine (p < 0.05). Peritoneal macrophages primed with Uro-BCG were shown to increase spontaneous production of IL-1b and decrease spontaneous production of TNFa (p < 0.05). When macrophages were primed by subcutaneous or intravenous administration of Mycobacterium tuberculosis strain H37Rv differentially affected cytokine production, by decreasing IL-1b production and increasing TNFa and IL-10, was observed. In response to lipopolysaccharide, peritoneal macrophages increased IL-1b, TNFa, IL-10 production and glucose consumption (p < 0.05). The mode of priming of macrophages with Mycobacterium tuberculosis strain H37Rv also led to multidirectional levels of cytokine production. Alveolar macrophages were shown to retain trained immunity, as they produced elevated levels of IL-1b, TNFa, and IL-10 (p < 0.05). Thus, mouse macrophages formed a trained immunity phenotype in response to different types of mycobacteria, which persists for a long time after primary contact with the pathogen, particularly in alveolar macrophages