Jerónimo Martins valuation through the lens of esg

This report reviews the literature about environmental, social, and governance investing, examines the correlation between the ESG ratings and cost of equity, and assesses the impact of ESG considerations on Jeronimo Martins’ Valuation. The results on Jeronimo Martins’ share price are mixed with two scenarios decreasing the share value to 21.28€ and 21.60€ and two scenarios increasing to 24.85€ and 28.24€

The Portuguese version of the RhinoQOL Questionnaire: validation and clinical application

AbstractIntroductionRhinosinusitis constitutes an important health problem, with significant interference in personal, professional, and social functioning. This study presents the validation process of the Portuguese version of the RhinoQOL, to be used as a routine procedure in the assessment of patients with chronic rhinosinusitis.ObjectiveTo demonstrate that the Portuguese version of the RhinoQOL is as valid as the English version to measure symptoms and health-related quality of life in chronic rhinosinusitis.MethodsThe Portuguese version of the RhinoQOL was administered consecutively to 58 patients with chronic rhinosinusitis with and without nasal polyps, assessed for endoscopic sinus surgery. A follow-up survey was completed three months after surgery. Statistical analysis was performed to determine its psychometric properties.ResultsFace and content validity were confirmed by similar internal consistency as the original questionnaire for each sub-scale, and strong correlation between individual items and total score. The questionnaire was easy and quick to administer (5.5min). At three months, there was a significant decrease from baseline for all sub-scale scores, indicating clinical improvement, with an effect size considered as large.ConclusionThis study provides a questionnaire that is equivalent to the original English version, with good responsiveness to change, which can be especially valuable to measure the outcome of surgery

Complexidade do método de ponto interior para o problema de rastreio regido pela equação de calor

Dissertação de mestrado em MatemáticaNeste trabalho são estudadas algumas questões relativas à complexidade de um método de caminho interior para o problema de rastreio regido pela equação do calor. Os resultados são ilustrados por um exemplo.In this work some complexity issues concerning the path-following method for the tracking problem for heat equation are studied. The results are illustrated by an example.Fundação para a Ciência e a Tecnologia (FCT) - Projeto de investigação PTDC/MAT/111809/2009.Fundo Europeu de Desenvolvimento Regional (FEDER).COMPETE - Programa Operacional Fatores de Competitividade (POFC)

Complexidade de métodos de ponto interior aplicados a problemas de otimização de dimensão infinita

Tese de Doutoramento em Ciências (Especialização em Matemática)Neste trabalho, são estudadas algumas questões relativas à regularidade da solução de problemas de cálculo das variações e de Lagrange. Como resultado desse estudo, apresentamos algumas estimativas explicitas para o controlo ótimo de alguns problemas específicos. Estas estimativas são ainda utilizadas para derivar um limite para a complexidade de um método de ponto interior aplicado a um problema de Lagrange convexo. Além disso, é ainda estudado o problema de rastreio regido pela equação do calor. Obtivemos uma aproximação por um problema de otimização de dimensão finita e, baseando-nos nessa aproximação, encontramos um limite para a complexidade do método de ponto interior aplicado ao problema de rastreio regido pela equação do calor.In this work, some questions regarding the regularity of solution for calculus of variations and Lagrange problems are studied. As a result of this study, we present some explicit estimates for the optimal control of some specific problems. These estimates are used to obtain bound to the complexity of an interior point method applied to a convex Lagrange problem. In addition, we study a tracking problem governed by the heat equation. We obtained an approximation by a finite-dimensional optimization problem and, based on this approximation, we find a bound for the complexity of the interior point method applied to the tracking problem governed by heat equation

Programação da produção: Otimização de Layouts Industriais

O problema conhecido na literatura como “Facility layout problem (FLP)”, em que se pretende determinar a disposição de recursos de produção e a sua interação num determinado espaço, é um problema estratégico para a implementação do chão de fábrica de uma empresa pelo impacto que tem na performance da produção. O problema consiste em encontrar um posicionamento único entre instalações (departamentos, máquinas, células de produção, armazéns, etc.) e localizações no chão de fábrica, de forma a otimizar um ou mais objetivos de produção. O objetivo da criação de layout consiste na otimização do espaço existente, minimização do tempo de produção, redução do custo de manuseamento de matérias, aumento do grau de flexibilidade, entre outros. A solução do problema deverá especificar a localização relativa de cada departamento (layout em bloco) e numa fase posterior poderá especificar o layout detalhado dentro de cada departamento. Na presente tese serão apresentados alguns modelos matemáticos para criação de um layout, neste caso vamos usar uma formulação matemática Quadratic Assignment Problem (QAP), uma formulação matemática Mixed Integer Programming (MIP) e uma heurística de Particle Swarm Optimization (PSO) para resolver problemas de layout. Todas estas formulações e modelos serão postos em prática para a resolução de problemas fictícios. Numa primeira abordagem iremos resolver problemas fictícios onde abordaremos a formulação QAP para problemas de atribuição de espaço de duas dimensões (x,y) e MIP e em seguida iremos usar a heurística PSO para a resolução de problemas em escala maior e real.The problem known in the literature as "Facility layout problem (FLP)", which is intended to determine the physical layout of industrial facilities, is a strategic problem for the implementation of a company by the impact it has on the production performance. The problem is to find an unambiguous allocation between facilities (departments, machines, production cells, warehouses, etc.) and locations on the shop floor in order to optimize one or more production goals. The objectives often considered are the optimization of the space, minimizing production time, reduce the handling costs of materials, increased flexibility, among others. The solution of the problem should specify the relative location of each department (block layout) and at a later stage it can specify the detailed layout within each department. In this thesis will be presented some methods of resolution in this case we use a discrete Quadratic Assignment formulation (QAP), a Mixed Integer Linear Programming formulation (MIP) and a Particle Swarm Optimization heuristic (PSO) to solve layout problems. All these heuristics will be implemented for solving fictitious problems. In a first approach we will solve simpler problems where we use the QAP and MIP formulation and following we will use the PSO heuristic to solve problems on a larger scale

Alternative regimens for treating prostate cancer using equivalent uniform dose and Monte Carlo methods

Introduction - Conventional radiotherapy treatments are administrated with 2 Gy external beam radiotherapy (EBRT) fractions. It has been postulated that prostate cancer would respond to radiotherapy as a slowly proliferating late-responding normal tissue, benefiting from hypo-fractionated regimens. Highly conformed brachytherapy is a treatment option either alone or combined with EBRT. Purpose - To identify alternative radiotherapy regimens for treating prostate cancer using EBRT and low dose-rate brachytherapy (LDRBT) with 125I implants, biologically equivalent to conventional treatments in terms of uniform equivalent dose (EUD). Materials and methods - The EUD concept was used, together with Monte Carlo (MC) methods. Two voxel phantoms were segmented from the computed tomography of patients to obtain the energy deposition derived from the MC simulations of EBRT and LDRBT treatments on a voxel-by-voxel basis. The energy deposition was converted in EUD. Equivalent regimens to EUDs of 72 Gy, 80 Gy, 90 Gy, and 100 Gy were determined for increasing fractions of 1.8–5.0 Gy and amounts of LDRBT from 0 Gy (EBRT exclusive) to 145 Gy. The resulting EUD for rectum was also evaluated. Results - Alternative schemes equivalent, in terms of EUD, were obtained. For example, it is equivalent to an EUD of 72 Gy, 38 × 2 Gy, 20 × 3 Gy or 9 × 5 Gy of EBRT, or 6 × 5 Gy of EBRT plus 50 Gy of LDRBT. The rectum benefits of higher amounts of LDRBT for EBRT fractionations <2.5 Gy and larger fractions for LDRBT dose <50 Gy. Conclusion - Alternative regimens for the treatment of prostate cancer with EBRT and LDRBT are proposed. The rational for the use of brachytherapy becomes less relevant with the increasing therapeutic ratio achieved with hypo-fractionated EBRT.info:eu-repo/semantics/publishedVersio

Leukocyte Imbalances in Mucopolysaccharidoses Patients

(This article belongs to the Special Issue Inherited Metabolic Disorders: From Bench to Bedside)Mucopolysaccharidoses (MPSs) are rare inherited lysosomal storage diseases (LSDs) caused by deficient activity in one of the enzymes responsible for glycosaminoglycans lysosomal degradation. MPS II is caused by pathogenic mutations in the IDS gene, leading to deficient activity of the enzyme iduronate-2-sulfatase, which causes dermatan and heparan sulfate storage in the lysosomes. In MPS VI, there is dermatan sulfate lysosomal accumulation due to pathogenic mutations in the ARSB gene, leading to arylsulfatase B deficiency. Alterations in the immune system of MPS mouse models have already been described, but data concerning MPSs patients is still scarce. Herein, we study different leukocyte populations in MPS II and VI disease patients. MPS VI, but not MPS II patients, have a decrease percentage of natural killer (NK) cells and monocytes when compared with controls. No alterations were identified in the percentage of T, invariant NKT, and B cells in both groups of MPS disease patients. However, we discovered alterations in the naïve versus memory status of both helper and cytotoxic T cells in MPS VI disease patients compared to control group. Indeed, MPS VI disease patients have a higher frequency of naïve T cells and, consequently, lower memory T cell frequency than control subjects. Altogether, these results reveal MPS VI disease-specific alterations in some leukocyte populations, suggesting that the type of substrate accumulated and/or enzyme deficiency in the lysosome may have a particular effect on the normal cellular composition of the immune system.This work was funded by National Funds through FCT—Fundação para a Ciência e a Tecnologia, I.P., under the project UIDB/04293/2020.info:eu-repo/semantics/publishedVersio