Kardioloogia

Eesti Arst 2012; 91(9):507–50

Ajuveresoonte seisund migreenihoo ajal. Magnetresonantstomograafia võimalused selle visualiseerimiseks

Eesti Arst 2016; 95(11):734–73

Silmahaigused

Eesti Arst 2016; 95(2):120–12

Militancy shines on the big screen, but democratic tactics actually won British women the vote

Dawn Langan Teele writes that although the recent film Suffragette bucks the elite perspective of the suffrage movement, any film which focusses exclusively on the militant wing ignores the key role played by the tens of thousands of non-militant suffragists. Her recent research focusses specifically on the alliance between the nascent Labour Party and the Liberal wing of the suffrage movement which was central to securing women’s inclusion in the 1918 Representation of the People Act

The only way is up: retail format saturation and the demise of the American five and dime store, 1914-1941

We examine a classic ‘wheel of retailing’ episode – the abandonment of the five and dime pricing formula by American variety chains. These switched from a conventional product lifecycle, focusing on cost reduction through standardisation, to a reverse path up the ‘service cost - unit value’ continuum. We show that, rather than reflecting deteriorating managerial acumen, this was a response to the continued imperative for growth following retail format saturation. Firm-specific (rather than format-specific) competitive advantages were too weak for any chain to be confident it could win a within-format price war, making inter-format competition through raising price points more attractive

Tidying up international nucleotide sequence databases

Sequence analysis of the ribosomal RNA operon, particularly the internal transcribed spacer (ITS) region, provides a powerful tool for identification of mycorrhizal fungi. The sequence data deposited in the International Nucleotide Sequence Databases (INSD) are, however, unfiltered for quality and are often poorly annotated with metadata. To detect chimeric and low-quality sequences and assign the ectomycorrhizal fungi to phylogenetic lineages, fungal ITS sequences were downloaded from INSD, aligned within family-level groups, and examined through phylogenetic analyses and BLAST searches. By combining the fungal sequence database UNITE and the annotation and search tool PlutoF, we also added metadata from the literature to these accessions. Altogether 35,632 sequences belonged to mycorrhizal fungi or originated from ericoid and orchid mycorrhizal roots. Of these sequences, 677 were considered chimeric and 2,174 of low read quality. Information detailing country of collection, geographical coordinates, interacting taxon and isolation source were supplemented to cover 78.0%, 33.0%, 41.7% and 96.4% of the sequences, respectively. These annotated sequences are publicly available via UNITE (http://unite.ut.ee/) for downstream biogeographic, ecological and taxonomic analyses. In European Nucleotide Archive (ENA; http://www.ebi.ac.uk/ena/), the annotated sequences have a special link-out to UNITE. We intend to expand the data annotation to additional genes and all taxonomic groups and functional guilds of fungi

Kaugisheemiline eelkohastamine – lihtne meetod elundikahjustuse vähendamiseks

Kaugisheemiline eelkohastamine (KIE) on meetod, mida kasutatakse sihtelundi isheemia-reperfusioonikahjustuse vähendamiseks. Meetod põhineb lühiajaliste isheemia- ja reperfusiooniepisoodide tekitamises, enamasti jäsemetel. KIE kaitsvat mõju ja mehhanisme on uuritud nii loomadel kui ka inimestel. Saadud on paljulubavaid tulemusi eelkõige südame ja neerude, kuid ka teiste elundite kaitses. Kõige rohkem on uuritud KIE rakendamise kasulikkust südameoperatsioonidel ja perkutaansetel koronaarinterventsioonidel, kuid ka kontrastainest põhjustatud nefropaatia vähendamisel. KIE täpsed mehhanismid ei ole teada, kuid on selge, et selles osaleb mitmeid signaalradasid. Uuringutes on leitud roll nii humoraalsetel, neuraalsetel faktoritel kui ka süsteemsel põletikulisel vastusel.Eesti Arst 2015; 94(11):661–66

The politics of immigration discourse among the contemporary British right: migration from East and Central Europe and societal security

http://tartu.ester.ee/record=b2655942~S1*es

CLIPPERS – haigusjuht ja kirjanduse ülevaade

CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids syndrome) on põletikuline, arvatavalt autoimmuunse geneesiga haigusseisund, millele on iseloomulik eeskätt ajutüve ja -silla piirkonna põletikuline aktiivsus, sageli perivaskulaarse ruumi kontrasteerumisega, ning hea ravivastus glükokortikoidravile. Lähtudes põletikukollete asukohast, on enam esinevad sümptomid kõnnakuataksia, diploopia, düsartria. Lisanduda võivad tinnitus, nüstagmid, paraparees ja iiveldus. Histoloogiliselt esineb valdavalt T-lümfotsüütide põhjustatud perivaskulaarse ruumi põletikuline haaratus nii valge- kui ka hallaines. Diagnoosimise eeldus on, et koos esinevad sobiv radioloogiline, kliiniline (sh ravivastus hormoonravile) ja histoloogiline leid. Tüüpiliselt on haigus kroonilise kuluga, ägenemistega ning sel juhul on vaja pikaaegset immuunsupressiivset ravi. CLIPPERSi diagnoosimiseks puuduvad spetsiifilised diagnostilised biomarkerid, mistõttu on selle eristamine teistest sarnastest haigusseisunditest oluliseks väljakutseks. Artiklis on käsitletud CLIPPERSi haigusjuhtu koos kirjanduse ülevaatega