Diversidade de insetos coletados com armadilha luminosa em plantio de mogno no interior de São Paulo.

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Dinâmica populacional da broca-do-mogno, Hypsipyla grandella (Lepidoptera: Pyralidae) em Garça, SP.

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Study of the impact of breeding seasons in the dynamics of dairy goat herds.

Abstract: The competitiveness in the animal production field has forced the smaller activities to be more efficient when compared to big business of the agro-industries. The dairy goat production is one of those market niches that need a better understand of its sector. For those reasons it has been proposed that by changing the number of reproduction seasons would increase income of the producers. The objectives of this study were to evaluate the impact of 1 or 2 annual reproductive cycles on production and economical health of dairy goats and to identify differences of production costs and revenues associated with changes in the herd dynamics as predicted by a mathematical model. A previously developed goat model using the System Dynamics approach to study long-term changes in the dynamics of the herd was used in these simulations. The model simulations used feeds, labor, and fixed costs as inputs and the outputs were revenues from milk production sales and sales of animals from all categories of the herd. The simulation time unit was ?month? and a long-term horizon of 10 years was considered for these simulations. The model was set up to simulate a freestall facility of a herd in equilibrium with 100 does in lactation. All parameters considered in this model assumed average values reported in production systems in the Southeast region of Brazil. The simulations results indicated that improvements of 10% in the fertility rate would increase the number animals in the herd up to 185% and 35% for one and two breeding season, respectively. Establishing a milk price as US$0.68 the break even for one and two breeding seasons was respectively US$0.62, and US$0.50, giving the systems with two breeding a capacity to support reductions on milk price up to 26% against 9% with one breeding season. When comparing the models with 1 or 2 breeding seasons was found that models with 2 breeding seasons was considerably more profitable and had a higher turnover than the model with 1 breeding season. The results indicate that the use of a second (artificial) breeding season might be an important management strategy to improve the efficiency of the dairy goat production systems. [Estudio del impacto de la estación reproductiva sobre la dinâmica de los rebaños lecheros]

A dairy goat model to study the impacts on herd dynamics.

The understanding of a dairy goat production system is crucial to establish a more competitive activity. Therefore, a simulation model was built to evaluate the dynamics of dairy goat herd under different scenarios of production. A System Dynamics approach was used to identify management policies that affect the behavior of the herd. All parameters considered in this model assumed average values reported in production systems in the Southeast region of Brazil. To simulate a herd in dynamic equilibrium, the culling and retention rates were used. Thereafter, simulations were performed based on changes in reproductive and mortality rates. All the simulations were planned to take the variation in herd development based on simple management strategies over 10 years of simulation. The dynamic equilibrium of 50 lactating does was obtained when fixed culling and retention rates of 20 and 70%, respectively, were assigned to the does after 36 months of simulation. A sensitivity analysis was made and indicated that an increase of 20% in the reproduction rates increased the number of animals in the herd in 56%. A decrease in the reproduction rate of 20% reduced the number of animals in 43%. A third simulation indicated that increasing mortality rate from 4 to 10% of the female kids decreased the number of lactating does by 36%. These results indicated that small changes in reproduction and mortality rates can considerably affect the dynamics of the herd, even though the herd may not be immediately affected because of the intrinsic delays in the system. This result is extremely important to justify the need of activity planning to consider the gap between a measurement taken and the consequences, preparing the producers to potential delays in the system. The use of mathematical models is important to understand the relationships between variables and the dynamic of the system and to assist in applying best management strategies to enhance productivity of dairy goats. [Modelo de cabras lecheras para evaluar el impacto de las estrategias de manejo en la dinámica del rebaño]

Insetos associados às sementes e frutos de espécies da arborização de Curitiba, PR.

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Indications, outcomes, and complications of neoumbilical reconstruction: A systematic review.

Neoumbilicoplasty aims to reconstruct an aesthetically pleasing new umbilicus following agenesis, malignancy, anatomical distortion, or umbilicus loss. Despite the wide variety of surgical techniques described, literature is scarce when it comes to standardized categorization of these as well as the clear definition of patients' selections, specific indications, final outcomes, and possible complications. According to available literature, this work aims to evaluate different surgical approaches, and correlate them to specific surgical needs, to simplify the surgical choice and patient management. A systematic review was performed in December 2020 in PubMed, Web of Science, and MedLine Ovid databases according to the PRISMA guidelines. A total of 41 studies and 588 patients were finally included. On the basis of the evidence of the literature collected, we divided the studies into four groups according to the neoumbilicoplasty techniques: single suture or purse-string suture, single flap, multiple flap, and skin graft. Patients' surgical comorbidities, neoumbilicoplasty indications, and aesthetic and surgical outcomes were investigated. Direct suture and single and multiple flap techniques assured overall, satisfactory cosmetic outcomes with a low rate of surgical complications. Whereas suture-only techniques were chosen mostly by general surgeons/urologists in laparoscopic surgery, the single flap was the preferred method to reconstruct the umbilicus in open abdominal surgery or combined abdominoplasty with herniorrhaphy. Multiple flap and skin grafts were adopted in abdominoplasty-related umbilicus reconstruction, although the latter option showed impactful aesthetic and surgical complications. Umbilicoplasty can assure generally pleasant aesthetic outcomes with relatively low complication rates. Indications for specific techniques correspond to different patient populations and surgical scenarios

A Proof of Concept of the Usefulness of a TDM-Guided Strategy for Optimizing Pharmacokinetic/Pharmacodynamic Target of Continuous Infusion Ampicillin-Based Regimens in a Case Series of Patients with Enterococcal Bloodstream Infections and/or Endocarditis

(1) Objective: To describe the usefulness of a real-time therapeutic drug monitoring (TDM)-based strategy for optimizing pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) ampicillin-based regimens in a case series of patients affected by suspected or documented enterococcal bloodstream infections (BSIs) and/or infective endocarditis (IE). (2) Methods: Patients treated with CI ampicillin-based regimens for documented or suspected enterococcal BSI/IE who underwent real-time therapeutic drug monitoring (TDM)-based expert clinical pharmacological advice (ECPA) between June 2021 and May 2022 were retrospectively assessed. Ampicillin concentrations were determined at steady state, and the free fraction (fC(ss)) was calculated according to a plasma protein binding of 20%. The fC(ss)/MIC ratio was selected as the PD parameter for ampicillin efficacy and was defined as optimal for values between 4 and 8. The requirement for TDM-guided ampicillin dosing adjustments was assessed. (3) Results: Data for 12 patients with documented (n = 10) or suspected (n = 2) enterococcal infections (7 with BSIs and 5 with IE) were retrieved. The ampicillin PK/PD target was optimal over time in all of the 10 documented infections. None of the enterococcal BSIs persisted. Following the first real-time TDM-based ECPA, ampicillin dosage was decreased by >50% in 11 out of 12 patients (91.7%). (4) Conclusions: CI may be helpful in attaining aggressive ampicillin PK/PD targets in patients affected by enterococcal BSIs and/or IE. Administration of CI ampicillin after loading coupled with real-time TDM-based ECPA could be a valuable strategy for managing enterococcal infections

The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs.

The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian orthologue DDX3 are critical for the initiation of translation1. Mutations in DDX3 are linked to tumorigenesis2-4 and intellectual disability5, and the enzyme is targeted by a range of viruses6. How Ded1p and its orthologues engage RNAs during the initiation of translation is unknown. Here we show, by integrating transcriptome-wide analyses of translation, RNA structure and Ded1p-RNA binding, that the effects of Ded1p on the initiation of translation are connected to near-cognate initiation codons in 5' untranslated regions. Ded1p associates with the translation pre-initiation complex at the mRNA entry channel and repressing the activity of Ded1p leads to the accumulation of RNA structure in 5' untranslated regions, the initiation of translation from near-cognate start codons immediately upstream of these structures and decreased protein synthesis from the corresponding main open reading frames. The data reveal a program for the regulation of translation that links Ded1p, the activation of near-cognate start codons and mRNA structure. This program has a role in meiosis, in which a marked decrease in the levels of Ded1p is accompanied by the activation of the alternative translation initiation sites that are seen when the activity of Ded1p is repressed. Our observations indicate that Ded1p affects translation initiation by controlling the use of near-cognate initiation codons that are proximal to mRNA structure in 5' untranslated regions

Neurology and the COVID-19 emergency

Following the COVID-19 outbreak, significant changes have been implemented on a national level in the organization of neurology units and associated stroke units. Regionallydesignated COVID-19 hospitals have implemented an aggressive policy to relocate as many beds as possible to COVID-19 patients. In order to do so, the preferred strategy has been to reduce the number of beds in neurology units, and in some cases several units have been consolidated into one. In other cases, particularly in the northern regions