2,114 research outputs found
Effective population size in relation to genetic modification of Anopheles gambiae sensu stricto
Effective population size (Ne) is a single number which allows us to relate a large part of population-genetics theory built around ideal populations to real populations. In the case of Anopheles gambiae, Ne is important to interpreting the temporal and spatial distribution of genes. These patterns are in turn used to explore the structure of (typically non-ideal) natural populations. We discuss the complex structure of An. gambiae s.s. in and around Banambani, Mali, as it is currently understood, based on estimates of Ne. This reveals a population that is structured temporally between and within years, spatially between villages and non-dimensionally into chromosomal forms. We suggest that the subpopulations of this species might usefully be viewed as a metapopulation. Successful and efficient genetic modification of An. gambiae will require as complete an understanding of their population structure as possible, which we believe can be attained through the convergence of multiple population-genetic techniques and the application of new method
Observational constraints on the neutron star mass distribution
Radio observations of neutron star binary pulsar systems have constrained
strongly the masses of eight neutron stars. Assuming neutron star masses are
uniformly distributed between lower and upper bounds and , the
observations determine with 95\% confidence that and . These limits give observational
support to neutron star formation scenarios that suggest that masses should
fall predominantly in the range , and will also be
important in the interpretation of binary inspiral observations by the Laser
Interferometer Gravitational-wave Observatory.Comment: Postscript, 4 pages, NU-GR-
WHIRLY proteins maintain seed longevity by effects on seed oxygen signalling during imbibition
The WHIRLY (WHY) family of DNA/RNA binding proteins fulfil multiple but poorly characterised functions in plants. We analysed WHY protein functions in the Arabidopsis Atwhy1, Atwhy3, Atwhy1why3 single and double mutants and wild type controls. The Atwhy3 and Atwhy1why3 double mutants showed a significant delay in flowering, having more siliques per plant but with fewer seeds per silique than the wild type. While germination was similar in the unaged high-quality seeds of all lines, significant decreases in vigour and viability were observed in the aged mutant seeds compared with the wild type. Imbibition of unaged high-quality seeds was characterised by large increases in transcripts that encode proteins involved in oxygen sensing and responses to hypoxia. Seed aging resulted in a disruption of the imbibition-induced transcriptome profile such that transcripts encoding RNA metabolism and processing became the most abundant components of the imbibition signature. The imbibition-related profile of the Atwhy1why3 mutant seeds, was characterised by decreased expression of hypoxia-related and oxygen metabolism genes even in the absence of aging. Seed aging further decreased the abundance of hypoxia-related and oxygen metabolism transcripts relative to the wild type. These findings suggest that the WHY1 and WHY3 proteins regulate the imbibition-induced responses to oxygen availability and hypoxia. Loss of WHY1 and WHY3 functions decreases the ability of Arabidopsis seeds to resist the adverse effects of seed aging
Segmentation of Loops from Coronal EUV Images
We present a procedure which extracts bright loop features from solar EUV
images. In terms of image intensities, these features are elongated ridge-like
intensity maxima. To discriminate the maxima, we need information about the
spatial derivatives of the image intensity. Commonly, the derivative estimates
are strongly affected by image noise. We therefore use a regularized estimation
of the derivative which is then used to interpolate a discrete vector field of
ridge points ``ridgels'' which are positioned on the ridge center and have the
intrinsic orientation of the local ridge direction. A scheme is proposed to
connect ridgels to smooth, spline-represented curves which fit the observed
loops. Finally, a half-automated user interface allows one to merge or split,
eliminate or select loop fits obtained form the above procedure. In this paper
we apply our tool to one of the first EUV images observed by the SECCHI
instrument onboard the recently launched STEREO spacecraft. We compare the
extracted loops with projected field lines computed from
almost-simultaneously-taken magnetograms measured by the SOHO/MDI Doppler
imager. The field lines were calculated using a linear force-free field model.
This comparison allows one to verify faint and spurious loop connections
produced by our segmentation tool and it also helps to prove the quality of the
magnetic-field model where well-identified loop structures comply with
field-line projections. We also discuss further potential applications of our
tool such as loop oscillations and stereoscopy.Comment: 13 pages, 9 figures, Solar Physics, online firs
Steroid-Induced Sigmoid Diverticular Perforation in a Patient with Temporal Arteritis: A Rare Clinical Pathology
Corticosteroids are used in the treatment of many rheumatological diseases including temporal arteritis. The gastrointestinal perforation during corticosteroid treatment is a serious complication. Colon perforation after steroid use was first reported by Beck et al in 1950.1 Although the pathophysiological mechanism is not understood clearly, it is claimed that steroids probably by disturbing the intestinal mucosal barrier, facilitate the intestinal perforation. The long term treatment with corticosteroids increases the risk of colon perforation. We are presenting a patient who was taking corticosteroid due to temporal arteritis for two years and operated with sigmoid diverticular perforation
Possible Effects of Noncommutative Geometry on Weak CP Violation and Unitarity Triangles
Possible effects of noncommutative geometry on weak CP violation and
unitarity triangles are discussed by taking account of a simple version of the
momentum-dependent quark mixing matrix in the noncommutative standard model. In
particular, we calculate nine rephasing invariants of CP violation and
illustrate the noncommutative CP-violating effect in a couple of charged
D-meson decays. We also show how inner angles of the deformed unitarity
triangles are related to CP-violating asymmetries in some typical B_d and B_s
transitions into CP eigenstates. B-meson factories are expected to help probe
or constrain noncommutative geometry at low energies in the near future.Comment: RexTev 16 pages. Modifications made. References added. Accepted for
publication in Phys. Rev.
The effect of Ganges river basin irrigation on preâmonsoon rainfall
The first experiment studying the effect of irrigation on pre-monsoon rainfall in India using a high-resolution convection-permitting model has been carried out. This study includes both short (3-day) experiments and month-long free-running simulations, enabling investigation of the effect of irrigation on mesoscale circulations and associated rainfall.
In the pre-monsoon, it is found that irrigation increases rainfall in our simulations. Intriguingly, the rainfall increase found in the high-resolution model mostly occurs on the mountains near the irrigation rather than over the irrigated region itself. This is because our applied irrigation is in low-lying regions, and so it enhances the mountain-valley flows leading to enhancement of diurnally driven orographic rainfall. Because Ganges basin irrigation occurs near mountains which already have some of the highest rainfall rates in the world, and which are subject to flash flooding and landslides, this has significant implications for hazards in mountainous regions during the pre-monsoon and early monsoon period
New polymorphic microsatellite markers for California sea lions (Zalophus californianus)
Nine microsatellite loci were isolated and characterized from California sea lions (Zalophus californianus). In addition, two of five loci tested from harbour seal (Phoca vitulina) produced a single, clear band in Z. californianus, as did one out of five loci from grey seal (Halichoerus grypus) and one out of two loci from elephant seal (Mirounga sp.). No locus tested from South American fur seal (Arctocephalus australis) amplified in Z. californianus. Locus variability was assessed in California sea lions from Los Islotes rookery, Baja California Sur, Mexico. All loci were variable, with allele numbers ranging from three to 12. © 2005 Blackwell Publishing Ltd.Peer Reviewe
Synchronous biological feedbacks in parrotfishes associated with pantropical coral bleaching
Biological feedbacks generated through patterns of disturbance are vital for sustaining ecosystem states. Recent ocean warming and thermal anomalies have caused pantropical episodes of coral bleaching, which has led to widespread coral mortality and a range of subsequent effects on coral reef communities. Although the response of many reefâassociated fishes to major disturbance events on coral reefs is negative (e.g., reduced abundance and condition), parrotfishes show strong feedbacks after disturbance to living reef structure manifesting as increases in abundance. However, the mechanisms underlying this response are poorly understood. Using biochronological reconstructions of annual otolith (ear stone) growth from two ocean basins, we tested whether parrotfish growth was enhanced following bleachingârelated coral mortality, thus providing an organismal mechanism for demographic changes in populations. Both major feeding guilds of parrotfishes (scrapers and excavators) exhibited enhanced growth of individuals after bleaching that was decoupled from expected thermal performance, a pattern that was not evident in other reef fish taxa from the same environment. These results provide evidence for a more nuanced ecological feedback systemâone where disturbance plays a key role in mediating parrotfishâbenthos interactions. By influencing the biology of assemblages, disturbance can thereby stimulate change in parrotfish grazing intensity and ultimately reef geomorphology over time. This feedback cycle operated historically at withinâreef scales; however, our results demonstrate that the scale, magnitude, and severity of recent thermal events are entraining the biological responses of disparate communities to respond in synchrony. This may fundamentally alter feedbacks in the relationships between parrotfishes and reef systems
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