The Knowledge Filter and Economic Growth: The Role of Scientist Entrepreneurship

Assesses the prevalence of and trends in the commercialization of research by university scientists funded by the National Cancer Institute. Analyzes levels of entrepreneurship in patenting choices and the role of university technology transfer offices

The Knowledge Filter and Economic Growth: The Role of Scientist Entrepreneurship

Assesses the prevalence of and trends in the commercialization of research by university scientists funded by the National Cancer Institute. Analyzes levels of entrepreneurship in patenting choices and the role of university technology transfer offices

Consulting with young people : informing guidelines for children's palliative care

Objective Increasingly the views of young people are sought when improving healthcare; however, it is unclear how they shape policy or practice. This paper presents a consultation with young people commissioned by the National Institute for Health and Care Excellence (NICE) to inform clinical guidelines for paediatric palliative care (end-of-life care for infants, children and young people). Methods The consultation involved qualitative thematic analysis of data from 14 young people (aged 12–18 years) with a life-limiting or life-threatening condition who took part in focus groups or interviews. The topics explored were predefined by NICE: information and communication; care planning; place of care; and psychological care. Data collection consisted of discussion points and activities using visual cues and was informed by a pilot consultation group with five young adults (aged 19–24 years). Findings were shared with participants, and feedback helped to interpret the findings. Results Four overarching themes were identified, cutting across the predetermined topic areas: being treated as individuals with individual needs and preferences; quality of care more important than place; emotional well-being; and living as a young person. Importantly, care planning was viewed as a tool to support living well and facilitate good care, and the young people were concerned less about where care happens but who provides this. Conclusion Young people’s priorities differ from those of parents and other involved adults. Incorporating their priorities within policy and practice can help to ensure their needs and preferences are met and relevant research topics identified

Control of Signaling in a MAP-kinase Pathway by an RNA-Binding Protein

Signaling-protein mRNAs tend to have long untranslated regions (UTRs) containing binding sites for RNA-binding proteins regulating gene expression. Here we show that a PUF-family RNA-binding protein, Mpt5, represses the yeast MAP-kinase pathway controlling differentiation to the filamentous form. Mpt5 represses the protein levels of two pathway components, the Ste7 MAP-kinase kinase and the Tec1 transcriptional activator, and negatively regulates the kinase activity of the Kss1 MAP kinase. Moreover, Mpt5 specifically inhibits the output of the pathway in the absence of stimuli, and thereby prevents inappropriate cell differentiation. The results provide an example of what may be a genome-scale level of regulation at the interface of signaling networks and protein-RNA binding networks

The lives of young carers in England omnibus survey report. Appendices to research report

The lives of young carers in England omnibus survey report. Appendices to research repor

Understanding the diverse needs of subtitle users in a rapidly evolving media landscape

Audiences are increasingly using services, such as video on demand and the Web, to watch television programs. Broadcasters need to make subtitles available across all these new platforms. These platforms also create new design opportunities for subtitles along with the ability to customize them to an individual’s needs. To explore these new opportunities for subtitles, we have begun the process of reviewing the guidance for subtitles on television and evaluating the original user research. We have found that existing guidelines have been shaped by a mixture of technical constraints, industry practice, and user research, constrained by existing technical standards. This paper provides an overview of the subtitle research at BBC R&D over the past two years. Our research is revealing significant diversity in the needs and preferences of frequent subtitle users, and points to the need for personalization in the way subtitles are displayed. We are developing a new approach to the authoring and display of subtitles that can respond to the user requirements by adjusting the subtitle layout on the client device

Comparison of engagement and emotional responses of older and younger adults interacting with 3D cultural heritage artefacts on personal devices

The availability of advanced software and less expensive hardware allows museums to preserve and share artefacts digitally. As a result, museums are frequently making their collections accessible online as interactive, 3D models. This could lead to the unique situation of viewing the digital artefact before the physical artefact. Experiencing artefacts digitally outside of the museum on personal devices may affect the user's ability to emotionally connect to the artefacts. This study examines how two target populations of young adults (18–21 years) and the elderly (65 years and older) responded to seeing cultural heritage artefacts in three different modalities: augmented reality on a tablet, 3D models on a laptop, and then physical artefacts. Specifically, the time spent, enjoyment, and emotional responses were analysed. Results revealed that regardless of age, the digital modalities were enjoyable and encouraged emotional responses. Seeing the physical artefacts after the digital ones did not lessen their enjoyment or emotions felt. These findings aim to provide an insight into the effectiveness of 3D artefacts viewed on personal devices and artefacts shown outside of the museum for encouraging emotional responses from older and younger people

OLES: An instrument for refining the design of e-learning environments

Designing and implementing effective e-learning is a complex process, which involves many factors. Lecturers need to constantly consider, evaluate and adjust these factors to provide effective e-learning environments for students. In this paper, we report on the design and development of the Online Learning Environment Survey (OLES), an instrument which can be used to gather and represent data on students' ‘actual’ (experienced) and ‘preferred’ (ideal) learning environments. We describe the use of this instrument in blended learning environments with university classes, illustrating how OLES can be used by educators striving for good practice in the design of effective online learning environments

Ambient temperature CO oxidation using palladium-platinum bimetallic catalysts supported on tin oxide/alumina

A series of Pt-based catalysts were synthesised and investigated for ambient temperature CO oxidation with the aim to increase catalytic activity and improve moisture resistance through support modification. Initially, bimetallic PtPd catalysts supported on alumina were found to exhibit superior catalytic activity compared with their monometallic counterparts for the reaction. Following an investigation into the effect of Pt/Pd ratio, a composition of 0.1% Pt/0.4% Pd was selected for further studies. Following this, SnO2/Al2O3 supports were synthesised from a variety of tin oxide sources. Catalytic activity was improved using sodium stannate and tin oxalate precursors compared with a traditional tin oxide slurry. Catalytic activity versus tin concentration was found to vary significantly across the three precursors, which was subsequently investigated by X-ray photoelectron spectroscopy (XPS) and energy-dispersive X-ray spectroscopy (EDX)