Reductive Dechlorination of Toxic Chlorocarbons

The sodium hydride based reducing agents were prepared the method of Caubere (Angew. Chem. Int. Ed. Engl., 1983, 22, 599-613). Reagents were prepared containing nickel, iron and zinc metals. All were effective in dechlorinating 1,3-dichlorobenzene, 4-methoxy-chlorobenzene, and arochlor 1254. Most work focused on nickel based reagents, the most active. The nickel-based reducing agent used in THF at 65°C reduced to 200 ppm 1,3-dichlorobenzene (to benzene) and arochlor 1254 (to biphenyl) to below 0.2 ppm in less than 15 minutes. A two stage reduction reduced arochlor 1254 to below a detectable level as determined by gas chromatography using f.i.d. detector. Using 1,3-dichlorobenzene as a model showed that the first halogen is reduced more rapidly. Accordingly, 4-methoxy-chlorobenzne was reduced to methoxybenzene less efficiently--but polychlorinated ethers are expected to react rapidly. The presence of water reduced the activity of the Ni catalyst--i.e.--reduced the rate of dechlorination. Two staged reductions of 1,3-dichlorobenzene using iron and zinc based catalysts at 65°, 1 hr per stage, gave more than 99% reduction. Use of the Ni based reagent as catalyst with hydrogen at 2 atm as reducing agent converted 1,3-dichlorobenzene to benzene; rate data have yet to be taken. The overall results provide a base for some additional pilot studies using the iron and zinc based reagents with the aim of increasing the reagent activity. The results are expected to give clearer directions for a planned comprehensive study

Polarized Radio Sources: A Study of Luminosity, Redshift and Infrared Colors

The Dominion Radio Astrophysical Observatory Deep Field polarization study has been matched with the Spitzer Wide-Area Infrared Extragalactic survey of the European Large Area Infrared Space Observatory Survey North 1 field. We have used VLA observations with a total intensity rms of 87 microJy beam^-1 to match SWIRE counterparts to the radio sources. Infrared color analysis of our radio sample shows that the majority of polarized sources are elliptical galaxies with an embedded active galactic nucleus. Using available redshift catalogs, we found 429 radio sources of which 69 are polarized with redshifts in the range of 0.04 < z <3.2. We find no correlation between redshift and percentage polarization for our sample. However, for polarized radio sources, we find a weak correlation between increasing percentage polarization and decreasing luminosity.Comment: 35 pages, 12 figures, accepted for publication in The Astrophysical Journa

Safety of dietary camelina oil supplementation in healthy, adult dogs

This study aimed to determine whether camelina oil is safe for use in canine diets, using canola oil and flax oil as controls, as they are similar and generally regarded as safe (GRAS) for canine diets. A total of thirty privately-owned adult dogs of various breeds (17 females; 13 males), with an average age of 7.2 ± 3.1 years (mean ± SD) and a body weight (BW) of 27.4 ± 14.0 kg were used. After a 4-week wash-in period using sunflower oil and kibble, the dogs were blocked by breed, age, and size and were randomly allocated to one of three treatment oils (camelina (CAM), flax (FLX), or canola (OLA)) at a level of 8.2 g oil/100 g total dietary intake. Body condition score (BCS), BW, food intake (FI), and hematological and select biochemical parameters were measured at various timepoints over a 16-week feeding period. All of the data were analyzed with ANOVA using the PROC GLIMMIX of SAS. No biologically significant differences were seen between the treatment groups in terms of BW, BCS, FI, and hematological and biochemical results. Statistically significant differences noted among some serum biochemical results were considered small and were due to normal biological variation. These results support the conclusion that camelina oil is safe for use in canine nutrition

Short-term changes in nightlife attendance and patron intoxication following alcohol restrictions in Queensland, Australia

Background: This study aims to explore short-term changes following the introduction of alcohol restrictions (most notably 2 am to 3 am last drinks). We examined patterns of nightlife attendance, intoxication, and alcohol use among patrons shortly before and after restrictions were introduced in Fortitude Valley, Brisbane: the largest nighttime entertainment precinct of Queensland. Methods: Street-intercept patron interviews were conducted in Fortitude Valley in June (n = 497) and July (n = 562) 2016. A pre-post design was used to assess changes in time spent out drinking/partying prior to the interview, time of arrival in the precinct, pre-drinking, and blood alcohol concentration (BAC). Results: Regression models indicated that after the policy introduction, the proportion of people arriving at Fortitude Valley before 10:00 pm increased (OR = 1.38; 95% CI = 1.04, 1.82). Participants reported going out, on average, one hour earlier after the intervention (β = − 0.17; 95% CI = 0.11, 0.22). There was a decrease (RRR = 0.58; 95% CI = 0.43, 0.79) in the proportion of participants who had a high level of intoxication (BAC ≥0.10 g/dL) postintervention. No other significant differences were found. Conclusions: Earlier cessation of alcohol sales and stopping the sale of rapid intoxication drinks after midnight was associated with people arriving in Fortitude Valley earlier. Though legislative loopholes allowed some venues to continue trading to 5 am, the proportion of people in the precinct who were highly intoxicated decreased after the restriction. Further measurement will be required to determine whether the reduction has persisted

Radio Polarimetry of the ELAIS N1 Field: Polarized Compact Sources

We present deep polarimetric observations at 1420 MHz of the European Large Area ISO Survey North 1 region (ELAIS N1) as part of the Dominion Radio Astrophysical Observatory Planck Deep Fields project. By combining closely spaced aperture synthesis fields, we image a region of 7.43 square degrees to a maximum sensitivity in Stokes Q and U of 78 microJy/beam, and detect 786 compact sources in Stokes I. Of these, 83 exhibit polarized emission. We find that the differential source counts (log N - log p) for polarized sources are nearly constant down to p > 500 microJy, and that these faint polarized radio sources are more highly polarized than the strong source population. The median fractional polarization is (4.8 +/- 0.7)% for polarized sources with Stokes I flux density between 1 and 30 mJy; approximately three times larger than sources with I > 100 mJy. The majority of the polarized sources have been identified with galaxies in the Spitzer Wide Area Infrared Extragalactic Survey (SWIRE) image of ELAIS N1. Most of the galaxies occupy regions in the IRAC 5.8/3.6 micron vs. 8.0/4.5 micron color-color diagram associated with dusty AGNs, or with ellipticals with an aging stellar population. A few host galaxies have colors that suggests significant PAH emission in the near-infrared. A small fraction, 12%, of the polarized sources are not detected in the SWIRE data. None of the polarized sources in our sample appears to be associated with an actively star-forming galaxy.Comment: 28 pages, 8 Figures. Figures 2 and 3 as separate gif images. Accepted for publication in the Astrophysical Journa

Structural basis for Fullerene geometry in a human endogenous retrovirus capsid

The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old. Many maintain intact open reading frames and provirus expression together with HML2 particle formation are observed in early stage human embryo development and are associated with pluripotency as well as inflammatory disease, cancers and HIV-1 infection. Here, we reconstruct the core structural protein (CA) of an HML2 retrovirus, assemble particles in vitro and employ single particle cryogenic electron microscopy (cryo-EM) to determine structures of four classes of CA Fullerene shell assemblies. These icosahedral and capsular assemblies reveal at high-resolution the molecular interactions that allow CA to form both pentamers and hexamers and show how invariant pentamers and structurally plastic hexamers associate to form the unique polyhedral structures found in retroviral cores

High levels of childhood obesity observed among 3- to 7-year-old New Zealand Pacific children is a public health concern.

This cross-sectional, community-based survey was designed to assess attained growth and body composition of 3- to 7-y-old Pacific children (n = 21 boys and 20 girls) living in Dunedin, New Zealand, and to examine nondietary factors associated with the percentage of body fat. Fat mass, lean tissue mass and the percentage of body fat were measured using dual energy X-ray absorptiometry. One trained anthropometrist also measured height, weight, skinfolds (triceps, subscapular) and circumferences (mid-upper arm, chest, waist, calf). Compared with the National Center for Health Statistics and National Health and Examination Surveys I and II reference data, these Pacific children were tall and heavy for their age with high arm-muscle-area-for-height. Median (quartiles) Z-scores for height and BMI-for-age and arm-muscle-area-for-height were 1.33 (0.60, 2.15), 1.20 (0.74, 4.43) and 1.09 (0.63, 1.85), respectively. Their median (quartile) percentage of body fat was 21.8% (15.0, 35.5) of which 38.5% was located in the trunk. The estimated percentage of children classified as obese ranged from 34 to 49% depending on the criterion used. Over 60% of the children had levels of trunk fat above 1 SD of reported age- and sex-specific Z-scores for New Zealand children. The nondietary factors examined (hours of television viewing and hours playing organized sports, as reported by parents) were not associated with variations in the percentage of body fat, after adjusting for age, sex and birth weight. These extremely high levels of obesity and truncal fat among very young New Zealand children will have major public health implications as these children age

Anatomy of bubbling solutions

We present a comprehensive analysis of holography for the bubbling solutions of Lin-Lunin-Maldacena. These solutions are uniquely determined by a coloring of a 2-plane, which was argued to correspond to the phase space of free fermions. We show that in general this phase space distribution does not determine fully the 1/2 BPS state of N=4 SYM that the gravitational solution is dual to, but it does determine it enough so that vevs of all single trace 1/2 BPS operators in that state are uniquely determined to leading order in the large N limit. These are precisely the vevs encoded in the asymptotics of the LLM solutions. We extract these vevs for operators up to dimension 4 using holographic renormalization and KK holography and show exact agreement with the field theory expressions.Comment: 67 pages, 6 figures; v2: typos corrected, refs added; v3: expanded explanations, more typos correcte

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.

BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy. METHODS: Data from different in vivo studies of ACT treatment of uncomplicated falciparum malaria were combined in a single database. Efficacy at day 28 corrected by PCR genotyping was estimated using four methods. In the first two methods, failure rates were calculated as proportions with either (1a) reinfections excluded from the analysis (standard WHO per-protocol analysis) or (1b) reinfections considered as treatment successes. In the second two methods, failure rates were estimated using the Kaplan-Meier product limit formula using either (2a) WHO (2001) definitions of failure, or (2b) failure defined using parasitological criteria only. RESULTS: Data analysed represented 2926 patients from 17 studies in nine African countries. Three ACTs were studied: artesunate-amodiaquine (AS+AQ, N = 1702), artesunate-sulphadoxine-pyrimethamine (AS+SP, N = 706) and artemether-lumefantrine (AL, N = 518).Using method (1a), the day 28 failure rates ranged from 0% to 39.3% for AS+AQ treatment, from 1.0% to 33.3% for AS+SP treatment and from 0% to 3.3% for AL treatment. The median [range] difference in point estimates between method 1a (reference) and the others were: (i) method 1b = 1.3% [0 to 24.8], (ii) method 2a = 1.1% [0 to 21.5], and (iii) method 2b = 0% [-38 to 19.3].The standard per-protocol method (1a) tended to overestimate the risk of failure when compared to alternative methods using the same endpoint definitions (methods 1b and 2a). It either overestimated or underestimated the risk when endpoints based on parasitological rather than clinical criteria were applied. The standard method was also associated with a 34% reduction in the number of patients evaluated compared to the number of patients enrolled. Only 2% of the sample size was lost when failures were classified on the first day of parasite recurrence and survival analytical methods were used. CONCLUSION: The primary purpose of an in vivo study should be to provide a precise estimate of the risk of antimalarial treatment failure due to drug resistance. Use of survival analysis is the most appropriate way to estimate failure rates with parasitological recurrence classified as treatment failure on the day it occurs