Restsim

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68439/2/10.1177_104687818301400404.pd

Cup products in the etale cohomology of number fields

This paper concerns cup product pairings in \'etale cohomology related to work of M. Kim and of W. McCallum and R. Sharifi. We will show that by considering Ext groups rather than cohomology groups, one arrives at a pairing which combines invariants defined by Kim with a pairing defined by McCallum and Sharifi. We also prove a formula for Kim's invariant in terms of Artin maps in the case of cyclic unramified Kummer extensions. One consequence is that for all $n > 1$, there are infinitely many number fields $F$ over which there are both trivial and non-trivial Kim invariants associated to cyclic groups of order $n$.Comment: 21 pages; in version 3 we changed the title of the paper and we restructured the pape

Combinatorial metabolic engineering platform enabling stable overproduction of lycopene from carbon dioxide by cyanobacteria

Cyanobacteria are simple, efficient, genetically-tractable photosynthetic microorganisms representing ideal biocatalysts for CO2 capture and conversion, in principle. In practice, genetic instability and low productivity are key, linked problems in engineered cyanobacteria. We took a massively parallel approach, generating and characterising libraries of synthetic promoters and RBSs for the cyanobacterium Synechocystis, and assembling a sparse combinatorial library of millions of metabolic pathway-encoding construct variants. Laboratory evolution suppressed variants causing metabolic burden in Synechocystis, leading to expected genetic instability. Surprisingly however, in a single combinatorial round without iterative optimisation, 80% of variants chosen at random overproduced the valuable terpenoid lycopene from atmospheric CO2 over many generations, apparently overcoming the trade-off between stability and productivity. This first large-scale parallel metabolic engineering of cyanobacteria provides a new platform for development of genetically stable cyanobacterial biocatalysts for sustainable light-driven production of valuable products directly from CO2, avoiding fossil carbon or competition with food production

Folic acid in pregnancy and mortality from cancer and cardiovascular disease : further follow-up of the Aberdeen folic acid supplementation trial

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. Acknowledgements The authors wish to acknowledge Professor Marion Hall, who set up the original randomised trial of folic acid supplementation. The authors also thank Ms Katie Wilde and the Data Management Team, University of Aberdeen, for their help with the extraction and linking of data and the data analysts from ISD Scotland.Peer reviewedPublisher PD

It\u27s a Way That They Have in Chicago

https://digitalcommons.library.umaine.edu/mmb-vp/5500/thumbnail.jp

A thrips vector of tomato spotted wilt virus responds to tomato acylsugar chemical diversity with reduced oviposition and virus inoculation.

There is increasing evidence that acylsugars deter insect pests and plant virus vectors, including the western flower thrips (WFT), Frankliniella occidentalis (Pergande), vector of tomato spotted wilt virus (TSWV). Acylsugars are sugar-polyesters composed of saturated, un-saturated, and variously branched short and long chain fatty acids (FAs) esterified to a glucose (acylglucose) or sucrose (acylsucrose) moiety. We sought to understand how acylsucrose amount and composition of associated FA profiles interacted to mediate resistance to WFT oviposition and TSWV inoculation on tomato leaves. Towards this goal, we examined WFT oviposition and TSWV inoculation behavior on tomato lines bred to exude varying amounts of acylsucrose in association with diverse FA profiles. Our data show that as acylsucrose amounts increased, WFT egg-laying (oviposition) decreased and TSWV inoculation was suppressed. Western flower thrips also responded to FA profiles that included iC4, iC11, nC12 and nC10 FA. These findings support improving acylsugar-mediated resistance against WFT by breeding tomatoes exuding greater amounts of acylsucrose associated with specific FA profiles. We show that increasing acylsucrose amount output by type IV trichomes and selecting for particular FA profiles through advanced breeding profoundly affects WFT behavior in ways that benefit management of WFT as direct pests and as TSWV vectors

Radio galaxies and their magnetic fields out to z <= 3

We present polarisation properties at $1.4\,$GHz of two separate extragalactic source populations: passive quiescent galaxies and luminous quasar-like galaxies. We use data from the {\it Wide-Field Infrared Survey Explorer} data to determine the host galaxy population of the polarised extragalactic radio sources. The quiescent galaxies have higher percentage polarisation, smaller radio linear size, and $1.4\,$GHz luminosity of $6\times10^{21}<L_{\rm 1.4}<7\times10^{25}\,$W Hz$^{-1}$, while the quasar-like galaxies have smaller percentage polarisation, larger radio linear size at radio wavelengths, and a $1.4\,$GHz luminosity of $9\times10^{23}<L_{\rm 1.4}<7\times10^{28}\,$W Hz$^{-1}$, suggesting that the environment of the quasar-like galaxies is responsible for the lower percentage polarisation. Our results confirm previous studies that found an inverse correlation between percentage polarisation and total flux density at $1.4\,$GHz. We suggest that the population change between the polarised extragalactic radio sources is the origin of this inverse correlation and suggest a cosmic evolution of the space density of quiescent galaxies. Finally, we find that the extragalactic contributions to the rotation measures (RMs) of the nearby passive galaxies and the distant quasar-like galaxies are different. After accounting for the RM contributions by cosmological large-scale structure and intervening Mg\,{II} absorbers we show that the distribution of intrinsic RMs of the distant quasar-like sources is at most four times as wide as the RM distribution of the nearby quiescent galaxies, if the distribution of intrinsic RMs of the WISE-Star sources itself is at least several rad m$^{-2}$ wide.Comment: 12 pages, 8 figures, accepted for publication into MNRA

Biosensor-based engineering of biosynthetic pathways

Biosynthetic pathways provide an enzymatic route from inexpensive renewable resources to valuable metabolic products such as pharmaceuticals and plastics. Designing these pathways is challenging due to the complexities of biology. Advances in the design and construction of genetic variants has enabled billions of cells, each possessing a slightly different metabolic design, to be rapidly generated. However, our ability to measure the quality of these designs lags by several orders of magnitude. Recent research has enabled cells to report their own success in chemical production through the use of genetically encoded biosensors. A new engineering discipline is emerging around the creation and application of biosensors. Biosensors, implemented in selections and screens to identify productive cells, are paving the way for a new era of biotechnological progress

Real-time auditing of domotic robotic cleaners

Domotic Robotic Cleaners are autonomous devices that are designed to operate almost entirely unattended. In this paper we propose a system that aims to evaluate the performance of such devices by analysis of their trails. This concept of trails is central to our approach, and it encompasses the traditional notion of a path followed by a robot between arbitrary numbers of points in a physical space. We enrich trails with context-specific metadata, such as proximity to landmarks, frequency of visitation, duration, etc. We then process the trail data collected by the robots, we store it an appropriate data structure and derive useful statistical information from the raw data. The usefulness of the derived information is twofold: it can primarily be used to audit the performance of the robotic cleaner –for example, to give an accurate indication of how well a space is covered (cleaned). And secondarily information can be analyzed in real-time to affect the behavior of specific robots – for example to notify a robot that specific areas have not been adequately covered. Towards our first goal, we have developed and evaluated a prototype of our system that uses a particular commercially available robotic cleaner. Our implementation deploys adhoc wireless local networking capability available through a surrogate device mounted onto this commodity robot; the device senses relative proximity to a grid of RFID tags attached to the floor. We report on the performance of this system in experiments conducted in a laboratory environment, which highlight the advantages and limitations of our approach