ВОЕННАЯ ПУБЛИЦИСТИКА НАЧАЛА XX В.: ЯЗЫКОВЫЕ ОСОБЕННОСТИ ПУБЛИЦИСТИЧЕСКИХ СТАТЕЙ Л. АНДРЕЕВА В СБОРНИКЕ «В СЕЙ ГРОЗНЫЙ ЧАС» (1914-1916)

Purpose. The relevance of the given study is connected with studying L. Andreev’s social and political essays and prose that can be characterized as an excellent stylistic example of military journalism during the First World War. The purpose of the study is to analyze the language features of L. Andreev’s journalistic articles in the collection Аt this terrible hour (1914–1916) on the lexical, morphological, and syntactic levels. The authors pay attention to the language characteristics of the articles in terms of expressing the patriotic ideas.Methodology and research methods. The authors use the following research methods: the contextual method of text elements analysis in terms of the contents, stylistic method of language means analysis taking into account the spheres of functioning.The results of the study.1. The language levels of L. Andreev’s journalistic texts form patriotic ideas that express the author’s comprehensive understanding of the military events.2. The expressive means used by L. Andreev in the collection Аt this terrible hour convey the pathos of the military journalism.3. The collection Аt this terrible hour by L. Andreev has its own religious, philosophical, civil position and forms the public opinion on the world war.Practical implications. The results of the study can be applied in comparative-historical literary studies.Цель. Актуальность исследования связана с рассмотрением малоизученной в филологической науке публицистики Л. Андреева, которая является стилистическим образцом военной публицистики периода первой мировой войны. Цель исследования: лингвистический анализ статей сборника «В сей грозный час» (1914–1916) на лексическом, морфологическом, синтаксическом уровнях. Уделяется внимание языковой характеристике статей с точки зрения выражения патриотической идеи.Метод или методология проведения работы:1. Контекстуальный метод анализа элементов текста с точки зрения содержательной нагрузки.2. Стилистический метод анализа языковых средств с учётом сфер функционирования.Результаты исследования:1. Языковые уровни публицистического текста Л. Андреева формируют патриотические идеи, выражающие комплексное понимание военных событий автором.2. Выразительные средства художественной речи, используемые Л. Андреевым в сборнике «В сей грозный час», передают пафос военной публицистики.3. В сборнике «В сей грозный час» Л. Андреев высказывает собственную религиозно-философскую, гражданскую позицию, формирует общественное мнение по вопросу мировой войны.Область применения результатов. Результаты исследования могут быть применены в сравнительно-исторических литературоведческих исследованиях

Intonation of Russian Declarative Sentence: Methodology for Teaching Foreign Students

The article deals with teaching Russian intonation of declarative sentences to foreign students. The emphasis is placed on the way teaching materials are presented. In particular, the variable rows for intonation patterns in declarative sentences have been developed, as well as the teaching of syntagmatic segmentation and intonation patterns in complex utterances. This method of working with foreigners is efficient for teaching foreign students the Russian declarative intonation which manifests in verbal communication and reading

Teaching Russian Interrogative Intonation to Foreign Students

The article deals with teaching Russian intonation of interrogative sentences to foreign students. Mastering this complex aspect of the Russian language causes great difficulties, and Russian intonation is not studied at the origin countries of foreign students. That is why we propose to study interrogative intonation based on variable rows developed by E.A. Bryzgunova. The rows enable students to improve the intonation structure of interrogative sentences, as well as their communication skills

Genome Environment Browser (GEB): a dynamic browser for visualising high-throughput experimental data in the context of genome features

<p>Abstract</p> <p>Background</p> <p>There is accumulating evidence that the milieu of repeat elements and other non-genic sequence features at a given chromosomal locus, here defined as the genome environment, can play an important role in regulating chromosomal processes such as transcription, replication and recombination. The availability of whole-genome sequences has allowed us to annotate the genome environment of any locus in detail. The development of genome wide experimental analyses of gene expression, chromatin modification and chromatin proteins means that it is now possible to identify potential links between chromosomal processes and the underlying genome environment. There is a need for novel bioinformatic tools that facilitate these studies.</p> <p>Results</p> <p>We developed the Genome Environment Browser (GEB) in order to visualise the integration of experimental data from large scale high throughput analyses with repeat sequence features that define the local genome environment. The browser has incorporated dynamic scales adjustable in real-time, which enables scanning of large regions of the genome as well as detailed investigation of local regions on the same page without the need to load new pages. The interface also accommodates a 2-dimensional display of repetitive features which vary substantially in size, such as LINE-1 repeats. Specific queries for preliminary quantitative analysis of genome features can also be formulated, results of which can be exported for further analysis.</p> <p>Conclusion</p> <p>The Genome Environment Browser is a versatile program which can be easily adapted for displaying all types of genome data with known genomic coordinates. It is currently available at <url>http://web.bioinformatics.ic.ac.uk/geb/</url>.</p

Congenital and Acquired Interferonopathies: Differentiated Approaches to Interferon Therapy

This chapter reviews various interferon (IFN) system disturbances—interferonopathies. The authors describe clinical specifics of type I interferonopathy associated with overexpression of IFNα—which is a rare Mendelian genetic disease. Certain autoimmune diseases (systemic lupus erythematosus (SLE), vasculitis, immune dysregulation syndrome, etc.) are also characterized by overproduction of IFNα. Furthermore the most common interferonopathies are described—deficiencies of IFN, congenital or acquired IFNα/IFNβ and IFNγ deficiencies in children and adults. Deficiency of IFNα/IFNβ associated with severe recurrent viral infections and deficiency of IFNγ cause mycobacterial infection. Interferon-corrective therapy methods are described. The target therapy of type I interferonopathies (biologics) binds IFNα and normalizes the high level of IFNα. From the other side, patients with congenital IFNα deficiencies are needed in replacement IFN therapy. In case of acquired IFNα deficiency, the differentiated interferon-corrective therapy is performed. In both replacement and interferon-corrective therapies, recombinant human IFNα2b in complex with antioxidants (Viferon®) can be used, because their application is safe and has good clinical efficiency and no side effects

Remodeling of Phenotype CD16 + CD11b + Neutrophilic Granulocytes in Acute Viral and Acute Bacterial Infections

Neutrophilic granulocytes (NGs) are very important cells of innate immunity that can very quickly realize antibacterial and antiviral defense. Until the present time, the phenomenon of different levels of presentations of membrane receptors CD16 and CD11b NG in normal and pathological conditions wasn’t studied. We had studied the population of CD16+CD11b+NG in two groups of patients with acute viral and acute bacterial infections in the models of acute bacterial tonsillitis (ABT) and acute viral tonsillitis-EBV infection (AEBVI), having the same clinical symptoms in early stages of the disease. Comparative analysis of the redistribution of equipment intensity of CD16 and CD11b has detected three subpopulations of CD16+CD11b+NG population—CD16brightCD11bbright, CD16brightCD11bdim, and CD16dimCD11bbright—in normal and pathological conditions. It was found that subpopulation CD16brightCD11bdimNG dominates in healthy individuals; subpopulation CD16brightCD11bbrightNG dominates in patients with acute viral infection; subpopulation CD16dimCD11bbrightNG dominates in patients with acute bacterial infections. We had demonstrated that the study of CD16+CD11b+NG subpopulations allows in early stage of diseases to diagnose acute viral and acute bacterial infections. Our studies have demonstrated the positive effects of eukaryotic DNA sodium salt on the negatively altered phenotype subpopulation CD16+CD11b+NG, in particular, through the remodeling of the expression of CD11b on NG membrane

Structure and expression pattern of Oct4 gene are conserved in vole Microtus rossiaemeridionalis

<p>Abstract</p> <p>Background</p> <p>Oct4 is a POU-domain transcriptional factor which is essential for maintaining pluripotency in several mammalian species. The mouse, human, and bovine <it>Oct4 </it>orthologs display a high conservation of nucleotide sequence and genomic organization.</p> <p>Results</p> <p>Here we report an isolation of a common vole (<it>Microtus rossiaemeridionalis) Oct4 </it>ortholog. Organization and exon-intron structure of vole <it>Oct4 </it>gene are similar to the gene organization in other mammalian species. It consists of five exons and a regulatory region including the minimal promoter, proximal and distal enhancers. Promoter and regulatory regions of the vole <it>Oct4 </it>gene also display a high similarity to the corresponding regions of <it>Oct4 </it>in other mammalian species, and are active during the transient transfection within luciferase reporter constructs into mouse P19 embryonic carcinoma cells and TG-2a embryonic stem cells. The vole <it>Oct4 </it>gene expression is detectable starting from the morula stage and until day 17 of embryonic development.</p> <p>Conclusion</p> <p>Genomic organization of this gene and its intron-exon structure in vole are identical to those in all previously studied species: it comprises five exons and the regulatory region containing several conserved elements. The activity of the <it>Oct4 </it>gene in vole, as well as in mouse, is confined only to pluripotent cells.</p

The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells

A panel of mutant embryonic stem (ES) cell lines lacking important chromatin modifiers was used to dissect the relationship between chromatin structure and replication timing, revealing the importance of several chromatin modifiers for maintaining correct replication of satellite sequences in pluripotent ES cells