Semantics and Completeness for Schematic Logic

This paper gives a semantics for schematic logic, proving soundness and completeness. The argument for soundness is carried out in ontologically innocent fashion, relying only on the existence of formulae which are actually written down in the course of a derivation in the logic. This makes the logic available to a nominalist, even a nominalist who does not wish to rely on modal notions, and who accepts the possibility that the universe may in fact be finite

The NSD1 and EZH2 overgrowth genes, similarities and differences.

NSD1 and EZH2 are SET domain-containing histone methyltransferases that play key roles in the regulation of transcription through histone modification and chromatin modeling: NSD1 preferentially methylates lysine residue 36 of histone 3 (H3K36) and is primarily associated with active transcription, while EZH2 shows specificity for lysine residue 27 (H3K27) and is associated with transcriptional repression. Somatic dysregulation of NSD1 and EZH2 have been associated with tumorigenesis. NSD1, as a fusion transcript with NUP98, plays a key role in leukemogenesis, particularly childhood acute myeloid leukemia. EZH2 is a major proto-oncogene and mono- and biallelic activating and inactivating somatic mutations occur as early events in the development of tumors, particularly poor prognosis hematopoietic malignancies. Constitutional NSD1 and EZH2 mutations cause Sotos and Weaver syndromes respectively, overgrowth syndromes with considerable phenotypic overlap. NSD1 mutations that cause Sotos syndrome are loss-of-function, primarily truncating mutations or missense mutations at key residues in functional domains. EZH2 mutations that cause Weaver syndrome are primarily missense variants and the rare truncating mutations reported to date are in the last exon, suggesting that simple haploinsufficiency is unlikely to be generating the overgrowth phenotype although the exact mechanism has not yet been determined. Many additional questions about the molecular and clinical features of NSD1 and EZH2 remain unanswered. However, studies are underway to address these and, as more cases are ascertained and technology improves, it is hoped that these will, in time, be answered

Baring it all : Hot Girls' representation of workers' experiences in internet pornography production : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Media Studies, Massey University, New Zealand

This thesis uses the Netflix feature documentary, Hot Girls Wanted (2015), and Netflix TV series, Hot Girls Wanted: Turned On (2017), as a lens for exploring the issues and challenges faced by workers in the contemporary internet pornography industries. It analyses connected representational concerns, both in terms of how these individuals’ workplace experiences are framed in the documentary and TV series, and in terms of the representational implications in online pornography and broader ‘pornified’ culture. The documentary and the TV series episodes (including “Money Shot”, “Take Me Private”, “Owning It”, and “Women on Top”) have been utilised as case studies to focus the discussion in each chapter around the representational issues they raise, including those related to gender, race, violence, coercion and mediated intimacy. I have examined interviews with the subjects, mise-en-scène, and cinematography and editing techniques chosen by the filmmakers, to highlight the ways in which Hot Girls represents the various emotional and physical struggles experienced by workers in the pornography industry. I then compare and contextualise this close scene analysis with what academic literature evidences about the experiences and representations of these workers, arguing that along with the proliferation of opportunities in the expanded internet pornography industries, there has also been an expansion of workplace and representational concerns

The cognitive profile of Sotos syndrome

Sotos syndrome is a congenital overgrowth disorder, associated with intellectual disability. Previous research suggests that Sotos syndrome may be associated with relative strength in verbal ability and relative weakness in non-verbal reasoning ability but this has not been explicitly assessed. To date, the cognitive profile of Sotos syndrome is unknown. Cognitive abilities of a large and representative sample of individuals with Sotos syndrome (N = 52) were assessed using the British Ability Scales (BAS3). The majority of participants had intellectual disability or borderline intellectual functioning. The cluster score profile analysis revealed a consistent verbal ability > non-verbal reasoning ability profile. Four specific criteria were proposed as the Sotos syndrome cognitive profile (SSCP): verbal ability > non-verbal reasoning ability; quantitative reasoning T-score or matrices T-score mean T-score. Of the 35 participants included in the profile analysis, 28 met all four SSCP criteria, yielding a sensitivity of 0.8. The sensitivity of each of the SSCP criteria was >0.9. Individuals with Sotos syndrome display a clear and consistent cognitive profile, characterized by relative strength in verbal ability and visuospatial memory but relative weakness in non-verbal reasoning ability and quantitative reasoning. This has important implications for the education of individuals with Sotos syndrome