Факторы инвестиционной привлекательности Калужской области

This article presents research of factors of investment attractiveness of the Kaluga region - a regional leader in formation of appealing investment climate for foreign investors and setting up  industrial technological parks. The indicators of the National  Investment Climate Ranking that has been used since 2016 are  discussed with regard to their content and structure. The author  argues that there is a need for extending the content-related  components of the Ranking by adding questions of the influence of  investment policy of the region on its socioeconomic development to  the major focus areas. The author has developed a methodology for  calculating an integrated investment climate indicator that  implements not only the basic idea of the need for additional  reviewing factors of investment climate, namely, development  potential of the region, performance of state administrative bodies and businesses, but also the basic requirements for monitoring - comparability of quantitative estimates over time and interregional  comparability of the indicators in question. Analysis of the statistical  information supports the author’s conclusion that effectiveness of  investment policy should be assessed not only by the results  achieved by the investors, but also by the socio-economic  development of the studied constituent entity.В статье приведены результаты исследования факторов инвестиционной привлекательности Калужской области - одного из региональных лидеров по формированию благоприятного  инвестиционного климата для иностранных инвесторов и созданию индустриальных парков  в России. Прокомментированы содержание и структура показателей применяемого с 2016 г.  Национального рейтинга состояния инвестиционного климата в субъектах Российской  Федерации. Аргументируется необходимость расширения содержательной составляющей  рейтинга за счет включения в группу рассматриваемых тем вопросов влияния инвестиционной политики региона на социально-экономическое развитие регионов. Автором разработана методология расчета интегрального индикатора инвестиционного климата,  реализующая не только основную идею относительно необходимости дополнительного  рассмотрения таких факторов инвестиционного климата, как потенциал развития региона,  результативность деятельности органов государственного управления и бизнеса, но и  основные требования к проведению мониторинга - сопоставимость количественных оценок  во времени и межрегиональная сопоставимость рассматриваемых показателей. На основе анализа статистической информации подтверждается авторский вывод относительно того,  что эффективность инвестиционной политики конкретного региона необходимо оценивать  не только с учетом достигаемых инвесторами результатов, но и социально-экономических результатов развития изучаемого субъекта Федерации

Tourism as a Factor of Increased Competitiveness of the Region

The paper considers tourism and tourism operations as one of the key priorities of increased competitive strengths of Russian regions, their area, socio- economic status and image. One of the presented ways of sustainable and effective development of tourism industry of the region is the formation of large-scale interregional, international associations conducting their activities for increased main competitive indicators and living conditions. Thus, the main function of performers of tourism operations of the considered territory will be to control work of regional agencies of local government that promotes increased quality of tourist management and defines the key possible priorities of development of the issues to solve being as follows: -development of a procedure of sharing experiences between regions; -attraction of an investor and additional financial means in the course of development of travel industry; - creation and promotion of positive image of the district, region and tourist base; - development of interregional projects which are in physical proximity of territories that promotes increase number of tourist routes and increases the potential of regions. Keywords: region, competitiveness, tourism, interregional ties, innovations, state JEL Classifications: F43, L83, O4

Spent fuel sabotage aerosol ratio program : FY 2004 test and data summary.

This multinational, multi-phase spent fuel sabotage test program is quantifying the aerosol particles produced when the products of a high energy density device (HEDD) interact with and explosively particulate test rodlets that contain pellets of either surrogate materials or actual spent fuel. This program has been underway for several years. This program provides data that are relevant to some sabotage scenarios in relation to spent fuel transport and storage casks, and associated risk assessments. The program also provides significant technical and political benefits in international cooperation. We are quantifying the Spent Fuel Ratio (SFR), the ratio of the aerosol particles released from HEDD-impacted actual spent fuel to the aerosol particles produced from surrogate materials, measured under closely matched test conditions, in a contained test chamber. In addition, we are measuring the amounts, nuclide content, size distribution of the released aerosol materials, and enhanced sorption of volatile fission product nuclides onto specific aerosol particle size fractions. These data are the input for follow-on modeling studies to quantify respirable hazards, associated radiological risk assessments, vulnerability assessments, and potential cask physical protection design modifications. This document includes an updated description of the test program and test components for all work and plans made, or revised, during FY 2004. It also serves as a program status report as of the end of FY 2004. All available test results, observations, and aerosol analyses plus interpretations--primarily for surrogate material Phase 2 tests, series 2/5A through 2/9B, using cerium oxide sintered ceramic pellets are included. Advanced plans and progress are described for upcoming tests with unirradiated, depleted uranium oxide and actual spent fuel test rodlets. This spent fuel sabotage--aerosol test program is coordinated with the international Working Group for Sabotage Concerns of Transport and Storage Casks (WGSTSC) and supported by both the U.S. Department of Energy and the Nuclear Regulatory Commission

Primary Health Care Challenges in Rural/Remote Areas of Yakutia and Use of Automated Systems for the Medical Screening Examination of the Pediatric Population

The negative consequences of social and economic changes in recent decades have primarily affected the rural population and violated the main principles of medical care organization for this group. The reduction by one third in the number of district hospitals, uncompensated by adequate development of outpatient care, and a shortage of doctors in rural clinics led to reduced availability of primary care. Specialized medical assistance in regional and national hospitals has also become less accessible to the rural population due to the high cost of travel. The number of doctors and nurses in rural areas is lower by 3.4 and 1.6 times, respectively, than in cities. In this regard, the burden and responsibility for rural health workers is much higher. Study of the opinions of the medical staff of the Northern and Arctic regions is an important part of the decision-making system in health care, allowing us to carry out modernization programs in the industry and increase their efficiency through feedback mechanisms. This article presents the available data on the problems of organizing medical assistance for residents of the Northern and Arctic regions of Yakutia, because dealing with these problems is still the most socially significant task for the authorities and carries a great load of negative experience, stereotypes, and scientific-methodological errors. To assess the quality of medical care, we conducted an anonymous survey of parents and medical staff of the Northern and Arctic regions of Yakutia. A total of 1,415 parents and 322 health specialists were interviewed between 2011 and 2012. The results of the anonymous survey revealed that in the Northern and Arctic regions of Yakutia there is a deficit of qualified specialists of different profiles, an unsatisfactory infrastructure of medical offices and hospitals, and a low level of income for medical personnel and the whole population. All above listed are some of the reasons for developing and implementing health care information technologies to improve the quality of medical services in remote settlements of Yakutia

A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis?

Thyroid hormones play a crucial role in regulating normal development, growth, and metabolic function. However, the controversy surrounding seasonal changes in free triiodothyronine (FT3) levels remains unresolved. Therefore, the aim of this study was to conduct a systematic review and meta-analysis of variations in FT3 levels in relation to seasonal air temperatures in the context of current knowledge about its role in nonshivering thermogenesis. Ten eligible articles with a total of 336,755 participants were included in the meta-analysis. The studies were categorized into two groups based on the air temperature: “Cold winter”, where the winter temperature fell below 0 °C, and “Warm winter”, where the winter temperature was above 0 °C. The analysis revealed that in cold regions, FT3 levels decreased in winter compared to summer (I2 = 57%, p 2 = 28%, p < 0.001). These findings suggest that seasonal variations in FT3 levels are likely to be influenced by the winter temperature. Considering the important role of the FT3 in the nonshivering thermogenesis process, we assume that this observed pattern is probably related to the differences in use of thyroid hormones in the brown adipose tissue during adaptive thermogenesis, which may depend on intensity of cold exposure

A rare case of Waardenburg syndrome with unilateral hearing loss caused by nonsense variant c.772C>T (p.Arg259*) in the MITF gene in Yakut patient from the Eastern Siberia (Sakha Republic, Russia)

Waardenburg syndrome (WS) is an orphan genetic disease with autosomal dominant pattern of inheritance characterised by varying degrees of hearing loss accompanied by skin, hair and iris pigmentation abnormalities. Four types of WS differing in phenotypic characteristics are now described. We performed a Sanger sequencing of coding regions of genes PAX3, MITF, SOX10 and SNAI2 in the patient with WS from a Yakut family living in the Sakha Republic. No changes were found in the PAX3, SOX10 and SNAI2 coding regions while a previously reported heterozygous transition c.772C>T (p.Arg259*) in exon 8 of the MITF gene was found in this patient. This patient presents rare phenotype of WS type 2: congenital unilateral hearing loss, unilateral heterochromia of irises, and absence of skin/hair depigmentation and dystopia canthorum. Audiological variability in WS type 2, caused by the c.772C>T (p.Arg259*) variant in the MITF gene, outlines the importance of molecular analysis and careful genotype–phenotype comparisons in order to optimally inform patients about the risk of hearing loss. The results of this study confirm the association of pathogenic variants in the MITF gene with WS type 2 and expanded data on the variability of audiological features of the WS