51 research outputs found
RUNX1 induces DNA replication independent active DNA demethylation at SPI1 regulatory regions
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10-8), 6q21 (rs9372120, P=9.09 × 10-15), 7q36.1 (rs7781265, P=9.71 × 10-9), 8q24.21 (rs1948915, P=4.20 × 10-11), 9p21.3 (rs2811710, P=1.72 × 10-13), 10p12.1 (rs2790457, P=1.77 × 10-8), 16q23.1 (rs7193541, P=5.00 × 10-12) and 20q13.13 (rs6066835, P=1.36 × 10-13), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development
Possible association of ?-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia
Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth
10.1158/0008-5472.CAN-06-4265Cancer Research67115328-533
Cutting‐edge morphological studies of post‐mortem brains of patients with schizophrenia and potential applications of X‐ray nanotomography (nano‐CT)
Computational thermodynamics and microstructure simulations to understand the role of grain boundary phase in Nd-Fe-B hard magnets
INVOLVEMENT OF CEREBRAL FUNCTIONS IN ACUTE CARBON MONOXIDE POISONING WITH SPECIAL REFERENCE TO OCCIPITAL LOBE FUNCTIONS
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