The Sanctuary of Athena Alea at Tegea: Recent Excavations in the Northern Area. Results and Problems

Papers from the third international seminar on Ancient Arcadia, held at the Norwegian Institute at Athens, 7-10 May 2002The excavations in the northern area of the sanctuary of Athena Alea at Tegea, organized by the Norwegian Institute at Athens during the period 1990-94, investigated the area directly in front of the 'ramp' emerging from the northern flank of the classical temple and identified a long stratigraphical sequence, from the modern occupation back to the early archaic period. This area was probably always used as an open courtyard, with few and small structures with the only exception of a big mud-brick wall in east-west direction, probably the northern limit of the sanctuary area in the 6th century B.C. The evidence recovered gives indications about the presence of early archaic and Geometric layers, which should be investigated by future excavations

La produzione ateniese di vasellame in bronzo in epoca arcaica e classica: forme, stile, caratteristiche

Since their discovery during the archaeological excavations managed on the Athenian Acropolis in the XIX century, many bronze vessels fragments of the archaic and early classical period weren’t carefully studied, leaving unknown this important class of materials. The recent analysis of a great part of these pieces (more than one thousand) allowed recognizing the more common shapes, their style and decoration, defining the characteristic of a local production, to which we can now attribute many pieces found in different, even far, places

La produzione ateniese di vasellame in bronzo in epoca arcaica e classica: forme, stile, caratteristiche

Since their discovery during the archaeological excavations managed on the Athenian Acropolis in the XIX century, many bronze vessels fragments of the archaic and early classical period weren't carefully studied, leaving unknown this important class of materials. The recent analysis of a great part of these pieces (more than one thousand) allowed recognizing the more common shapes, their style and decoration, defining the characteristic of a local production, to which we can now attribute many pieces found in different, even far, places

siRNA screen identifies QPCT as a druggable target for Huntington's disease.

Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified new modifiers of mutant HTT toxicity by performing a large-scale 'druggable genome' siRNA screen in human cultured cells, followed by hit validation in Drosophila. We focused on glutaminyl cyclase (QPCT), which had one of the strongest effects on mutant HTT-induced toxicity and aggregation in the cell-based siRNA screen and also rescued these phenotypes in Drosophila. We found that QPCT inhibition induced the levels of the molecular chaperone αB-crystallin and reduced the aggregation of diverse proteins. We generated new QPCT inhibitors using in silico methods followed by in vitro screening, which rescued the HD-related phenotypes in cell, Drosophila and zebrafish HD models. Our data reveal a new HD druggable target affecting mutant HTT aggregation and provide proof of principle for a discovery pipeline from druggable genome screen to drug development

Fragments of metal vessels from the northern sector

Study of the bronze vessels fragments found during the excavations in the sanctuary of Athena Alea at Tegea, years 1990-199

The Sanctuary of Athena Alea at Tegea: Recent Excavations in the Northern Area. Results and Problems

The excavations in the northern area of the sanctuary of Athena Alea at Tegea, organized by the Norwegian Institute at Athens during the period 1990-94, investigated the area directly in front of the 'ramp' emerging from the northern flank of the classical temple and identified a long stratigraphical sequence, from the modern occupation back to the early archaic period. This area was probably always used as an open courtyard, with few and small structures with the only exception of a big mud-brick wall in east-west direction, probably the northern limit of the sanctuary area in the 6th century B.C. The evidence recovered gives indications about the presence of early archaic and Geometric layers, which should be investigated by future excavations