2,162 research outputs found

    On infinite-finite duality pairs of directed graphs

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    The (A,D) duality pairs play crucial role in the theory of general relational structures and in the Constraint Satisfaction Problem. The case where both classes are finite is fully characterized. The case when both side are infinite seems to be very complex. It is also known that no finite-infinite duality pair is possible if we make the additional restriction that both classes are antichains. In this paper (which is the first one of a series) we start the detailed study of the infinite-finite case. Here we concentrate on directed graphs. We prove some elementary properties of the infinite-finite duality pairs, including lower and upper bounds on the size of D, and show that the elements of A must be equivalent to forests if A is an antichain. Then we construct instructive examples, where the elements of A are paths or trees. Note that the existence of infinite-finite antichain dualities was not previously known

    Aging Phenotypes of Common Marmosets (Callithrix Jacchus)

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    Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed to determine if phenotypes of body composition, hematology, and morphometrical measures were associated with age or risk of death. We found that the cause of mortality in older marmosets was more likely to be due to cardiac and chronic kidney disease than in younger marmosets. Older marmosets have decreased fat mass, morphometric measures, and serum albumin. Older marmosets are more likely to show a modified posture while at rest and this modified posture was significantly associated with an increased risk of imminent death. These assessments provide an initial definition of aged health in marmosets and a base for future translational aging research with this species

    Exchange bias in GeMn nanocolumns: the role of surface oxidation

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    We report on the exchange biasing of self-assembled ferromagnetic GeMn nanocolumns by GeMn-oxide caps. The x-ray absorption spectroscopy analysis of this surface oxide shows a multiplet fine structure that is typical of the Mn2+ valence state in MnO. A magnetization hysteresis shift |HE|~100 Oe and a coercivity enhancement of about 70 Oe have been obtained upon cooling (300-5 K) in a magnetic field as low as 0.25 T. This exchange bias is attributed to the interface coupling between the ferromagnetic nanocolumns and the antiferromagnetic MnO-like caps. The effect enhancement is achieved by depositing a MnO layer on the GeMn nanocolumns.Comment: 7 pages, 5 figure

    Synoptic-Scale Atmospheric Circulation and Boreal Canada Summer Drought Variability of the Past Three Centuries

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    Five independent multicentury reconstructions of the July Canadian Drought Code and one reconstruction of the mean July-August temperature were developed using a network of 120 well-replicated tree-ring chronologies covering the area of the eastern Boreal Plains to the eastern Boreal Shield of Canada. The reconstructions were performed using 54 time-varying reconstruction submodels that explained up to 50% of the regional drought variance during the period of 1919-84. Spatial correlation fields on the six reconstructions revealed that the meridional component of the climate system from central to eastern Canada increased since the mid-nineteenth century. The most obvious change was observed in the decadal scale of variability. Using 500-hPa geopotential height and wind composites, this zonal to meridional transition was interpreted as a response to an amplification of long waves flowing over the eastern North Pacific into boreal Canada, from approximately 1851 to 1940. Composites with NOAA Extended Reconstructed SSTs indicated a coupling between the meridional component and tropical and North Pacific SST for a period covering at least the past 150 yr, supporting previous findings of a summertime global ocean-atmospherel-and surface coupling. This change in the global atmospheric circulation could be a key element toward understanding the observed temporal changes in the Canadian boreal forest fire regimes over the past 150 yr

    Sibling sex, but not androgens, shapes phenotypes in perinatal common marmosets (\u3ci\u3eCallithrix jacchus\u3c/i\u3e)

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    When offspring share a womb, interactions among fetuses can impart lasting impressions on phenotypic outcomes. Such intrauterine interactions often are mediated by sex steroids (estrogens and androgens) produced by the developing fetuses. In many mammals, intrauterine interactions between brothers and sisters lead to masculinization of females, which can induce fitness consequences. Many litter-bearing primates, though, seem to escape androgen-mediated litter effects, begging why? Here, we investigated how the sex composition (i.e., same- or mixed-sex) of litters influences perinatal outcomes in the common marmoset monkey (Callithrix jacchus), using a combination of physiological, morphological, and behavioural assays. We hypothesized that androgens from male fetuses would mediate developmental differences across litter types. We found that newborns (24–36 hours old) from same- and mixed-sex litters were indistinguishable by urinary androgen profiles, birth weights, morphometrics, and behaviour. However, monkeys born into same- and mixed-sex litters exhibited subtle morphological and neurobehavioral differences later in the perinatal period, independent of their androgen profiles. Our findings suggest that while androgens from male fetuses likely do not organize their siblings’ phenotypes, perinatal stimuli may initiate divergent developmental trajectories among siblings, which, in turn, promotes inter-individual variability within families

    Nonhuman Primate Induced Pluripotent Stem Cells in Regenerative Medicine

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    Among the various species from which induced pluripotent stem cells have been derived, nonhuman primates (NHPs) have a unique role as preclinical models. Their relatedness to humans and similar physiology, including central nervous system, make them ideal for translational studies. We review here the progress made in deriving and characterizing iPS cell lines from different NHP species. We focus on iPS cell lines from the marmoset, a small NHP in which several human disease states can be modeled. The marmoset can serve as a model for the implementation of patient-specific autologous cell therapy in regenerative medicine
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