Diversité des insectes actifs au sol dans quatre écosystèmes de bas-fonds du Burkina Faso : importance pour la détermination de bio-indicateurs caractérisant ces milieux

L'action de l’Homme sur l'environnement peut affecter la diversité biologique qui à son tour peut être utilisée comme indicateur de la santé des écosystèmes. Une étude a été menée en 2006 dans quatre (4) MicroBassin-Versants (MBV) du Burkina Faso pour évaluer la diversité des insectes rampants au sol et caractériser chaque écosystème par ses bio-indicateurs les plus significatifs. La diversité taxonomique des espècesd’insectes capturées dans différents sites par des pièges de Barber, leur distribution et leur abondance relative au début et à la fin de la saison des pluies ont ainsi été déterminées. Quatre (4) ordres regroupant treize (13)familles d’insectes, les Carabidae, les Scarabaeidae, les Tenebrionidae, les Cétonidae, les Cérambycidae, les Curculionidae, les Hydrophilidae, les Elateridae, les Staphylinidae, les Chrysomelidae (Coléoptères), lesFormicidae (Hyménoptères), les Gryllidae (Orthoptères) et les Labiduridae (Dermaptères), ont été identifiées dans les MBV étudiés. Les variations climatiques influencent la diversité taxonomique des insectes qui fluctuepar ailleurs dans l’espace et dans le temps. Cinq (5) familles, les Formicidae, les Cicindellidae, les Carabidae, les Scarabaeidae et les Tenebrionidae ont été les plus abondantes et les plus diversifiées en espèces dans chacun des quatre MBV. Ces taxa, qui se sont adaptés aux écosystèmes étudiés, en sont probablement les meilleurs indicateurs. Les résultats obtenus sont discutés en vue de déterminer comment ces groupes majeurs peuvent être utilisés dans l’évaluation et la gestion des écosystèmes qu’ils peuplent

Nosocomial Urinary Infections at the Urogoly Unit of the National University Hospital (Yalgado Ouedraogo), Ouagadougou: Feb.-Sept. 2012

Objective: The aim of this study was to identify the risk factors and the microorganisms susceptibilities of nosocomial urinary infections at the urology unit of the national university hospital of Ouagadougou in Burkina Faso.Method: From February to September 2012, two bacteriological analyzes have been performed for any of the 75 inpatients in the urology unit of the national university hospital of Ouagadougou in Burkina Faso.Results: During the study period, 43 cases of nosocomial urinary infection were identified (57.3%) and we found no statistically significant associated risk factors with age groups, sex, arterial blood pressure, kidney illness and urinary obstructive pathologies.The most frequently isolated bacteria were Escherichia coli (30.9%),  Klebsiella spp (26.9%) and Staphylococcus spp (15.4%). The yeasts strains were very sensitive to antifungal but the bacteria susceptibility rate to antibiotics was very variable. Thus, the cocci were rather sensitive to  association clavulanic acid + amoxicilline and ceftriaxone and enoughsensitive to gentamicine ; the bacilli were enough sensitive to gentamicin and very sensitive to imipenem.Conclusion: From the antibiogram results, we recommend gentamicin in combination with penicillin or metronidazole as the first antibiotics to be used in the treatment of nosocomial urinary tract infections.Keywords: urinary infection, nosocomial infection, bacteria, antibiotic

Hernie diaphragmatique post-traumatique de l’enfant: à propos d’un cas au Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle de Ouagadougou

La hernie diaphragmatique post-traumatique est une urgence chirurgicale rare chez l’enfant mais pouvant mettre rapidement en jeu le pronosticvital. Les auteurs rapportent le cas d’un garçon de 04 ans admis aux urgences pour douleur abdominale suite à une contusion thoraco-abdominale par accident de la voie publique. Le bilan radiologique initial a consisté en une échographie abdominale qui a révélé un hémopéritoine de petite abondance sans lésion focale. Douze heures après son admission, le patient a présenté une détresse respiratoire avec tableau clinique depneumothorax gauche qui a nécessité une exsufflation en urgence. Le diagnostic de hernie diaphragmatique gauche a été posé à la radiographiedu thorax réalisée après la ponction. L’enfant a bénéficié d’une cure  chirurgicale. L’évolution a été favorable. La hernie diaphragmatique posttraumatique, bien que rare chez l’enfant, devrait être systématiquement recherchée par une radiographie thoracique ou un scanner  thoracoabdominal devant tout traumatisme abdominal avec hyper pression. Son traitement est chirurgical

Looking back, moving forward: Understanding the HIV risk and sexual health needs of men who have sex with men, Horizons studies 2001 to 2008

In 1997, the Population Council initiated the Horizons Program—a decade-long USAID-funded collaboration with the International Center for Research on Women, the International HIV/AIDS Alliance, PATH, Tulane University, Family Health International, and Johns Hopkins University—designing, implementing, evaluating, and expanding innovative strategies for HIV prevention and care. Horizons developed and tested ways to optimize HIV prevention, care, and treatment programs; worked to reduce stigma and improve gender-biased behaviors; and greatly expanded knowledge about the best ways to support, protect, and treat children affected by HIV and AIDS. In all its projects, Horizons strengthened the capacity of local institutions by providing support and training to colleagues. This synthesis paper presents lessons learned and best practices on one of the key topics that Horizons investigated: understanding the HIV risk and sexual health needs of men who have sex with men

Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine

The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover been shown to selectively inhibit the Plasmodium falciparum glutathione reductase. In 2004, an uncontrolled dose-finding study on the combination MB-CQ was performed in 435 young children with uncomplicated falciparum malaria in Burkina Faso ( CQ monotherapy had a > 50% clinical failure rate in this area in 2003). Three serious adverse events (SAE) occurred of which one was probably attributable to the study medication. In the per protocol safety analysis, there were no dose specific effects. The overall clinical and parasitological failure rates by day 14 were 10% [95% CI (7.5%, 14.0%)] and 24% [ 95% CI (19.4%, 28.3%)], respectively. MB appears to have efficacy against malaria, but the combination of CQ-MB is clearly not effective in the treatment of malaria in Africa

Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]

BACKGROUND: Safe, effective and affordable drug combinations against falciparum malaria are urgently needed for the poor populations in malaria endemic countries. Methylene blue (MB) combined with chloroquine (CQ) has been considered as one promising new regimen. OBJECTIVES: The primary objective of this study was to evaluate the safety of CQ-MB in African children with uncomplicated falciparum malaria. Secondary objectives were to assess the efficacy and the acceptance of CQ-MB in a rural population of West Africa. METHODS: In this hospital-based randomized controlled trial, 226 children (6–59 months) with uncomplicated falciparum malaria were treated in Burkina Faso. The children were 4:1 randomized to CQ-MB (n = 181; 25 mg/kg CQ and 12 mg/kg MB over three days) or CQ (n = 45; 25 mg/kg over three days) respectively. The primary outcome was the incidence of severe haemolysis or other serious adverse events (SAEs). Efficacy outcomes were defined according to the WHO 2003 classification system. Patients were hospitalized for four days and followed up until day 14. RESULTS: No differences in the incidence of SAEs and other adverse events were observed between children treated with CQ-MB (including 24 cases of G6PD deficiency) compared to children treated with CQ. There was no case of severe haemolysis and also no significant difference in mean haemoglobin between study groups. Treatment failure rates were 53.7% (95% CI [37.4%; 69.3%]) in the CQ group compared to 44.0% (95% CI [36.3%; 51.9%]) in the CQ-MB group. CONCLUSION: MB is safe for the treatment of uncomplicated falciparum malaria, even in G6PD deficient African children. However, the efficacy of the CQ-MB combination has not been sufficient at the MB dose used in this study. Future studies need to assess the efficacy of MB at higher doses and in combination with appropriate partner drugs

Dietary patterns of adults living in Ouagadougou and their association with overweight

<p>Abstract</p> <p>Background</p> <p>Urbanization in developing countries comes along with changes in food habits and living conditions and with an increase in overweight and associated health risks. The objective of the study was to describe dietary patterns of adults in Ouagadougou and to study their relationship with anthropometric status of the subjects.</p> <p>Methods</p> <p>A qualitative food frequency questionnaire was administered to 1,072 adults living in two contrasted districts of Ouagadougou. Dietary patterns were defined by principal component analysis and described by multivariate analysis. Logistic regression was used to study their association with overweight.</p> <p>Results</p> <p>The diet was mainly made of cereals, vegetables and fats from vegetable sources. The two first components of the principal component analysis were interpreted respectively as a "snacking" score and as a "modern foods" score. Both scores were positively and independently associated with the economic level of households and with food expenditures (p ≤ 0.001 for both). The "snacking" score was higher for younger people (p = 0.004), for people having a formal occupation (p = 0.006), for those never married (p = 0.005), whereas the "modern foods" score was associated with ethnic group (p = 0.032) and district of residence (p < 0.001). Thirty-six percent of women and 14.5% of men were overweight (Body Mass Index > 25 kg/m²). A higher "modern foods" score was associated with a higher prevalence of overweight when confounding factors were accounted for (OR = 1.19 [95% CI 1.03-1.36]) but there was no relationship between overweight and the "snacking" score.</p> <p>Conclusions</p> <p>Modernisation of types of foods consumed was associated with the living conditions and the environment and with an increased risk of overweight. This should be accounted for to promote better nutrition and prevent non communicable diseases.</p

A Newly Identified Susceptibility Locus near FOXP1 Modifies the Association of Gastroesophageal Reflux with Barrett's Esophagus

Important risk factors for esophageal adenocarcinoma (EA) and its precursor, Barrett’s esophagus (BE) include gastroesophageal reflux disease, obesity, and cigarette-smoking. Recently, genome-wide association studies have identified seven germline single nucleotide polymorphisms (SNPs) that are associated with risk of BE and EA. Whether these genetic susceptibility loci modify previously identified exposure-disease associations is unclear