4,978 research outputs found

    A framework for second-order parton showers

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    A framework is presented for including second-order perturbative corrections to the radiation patterns of parton showers. The formalism allows to combine O(alphaS^2)-corrected iterated 2->3 kernels for "ordered" gluon emissions with tree-level 2->4 kernels for "unordered" ones. The combined Sudakov evolution kernel is thus accurate to O(alphaS^2). As a first step towards a full-fledged implementation of these ideas, we develop an explicit implementation of 2->4 shower branchings in this letter.Comment: 11 pages, 3 figure

    Higher-order hadronic and heavy-lepton contributions to the anomalous magnetic moment

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    We report about recent results obtained for the muon anomalous magnetic moment. Three-loop kernel functions have been computed to obtain the next-to-next-to-leading-order hadronic vacuum polarization contributions. The numerical result, aμhad,NNLO=1.24±0.01×1010a_\mu^{\rm{had,NNLO}}=1.24\pm 0.01 \times 10^{-10}, is of the same order of magnitude as the current uncertainty from the hadronic contributions. For heavy-lepton corrections, analytical results are obtained at four-loop order and compared with the known results.Comment: Contribution to the proceedings of Loops and Legs in Quantum Field Theory, 27 April - 2 May 2014, Weimar, German

    TeV Lepton Number Violation: From Neutrinoless Double Beta Decay to the LHC

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    We analyze the sensitivity of next-generation tonne-scale neutrinoless double β\beta-decay (0νββ0\nu\beta\beta) experiments and searches for same-sign di-electrons plus jets at the Large Hadron Collider to TeV scale lepton number violating interactions. Taking into account previously unaccounted for physics and detector backgrounds at the LHC, renormalization group evolution, and long-range contributions to 0νββ0\nu\beta\beta nuclear matrix elements, we find that the reach of tonne-scale 0νββ0\nu\beta\beta generally exceeds that of the LHC. However, for a range of heavy particle masses near the TeV scale, the high luminosity LHC and tonne-scale 0νββ0\nu\beta\beta may provide complementary probes.Comment: 5 pages, 3 figure

    Hadronic contribution to the muon anomalous magnetic moment to next-to-next-to-leading order

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    We compute the next-to-next-to-leading order hadronic contribution to the muon anomalous magnetic moment originating from the photon vacuum polarization. The corresponding three-loop kernel functions are calculated using asymptotic expansion techniques which lead to analytic expressions. Our final result, aμhad,NNLO=1.24±0.01×1010a_\mu^{\rm had,NNLO} = 1.24 \pm 0.01 \times 10^{-10}, has the same order of magnitude as the current uncertainty of the leading order hadronic contribution and should thus be included in future analyses.Comment: 9 pages,v2: note on NLO hadronic light-by-light contribution added, matches published version, Physics Letters B 734 (2014) 144-14

    A phosphorylcholine-containing glycolipid-like antigen present on the surface of infective stage larvae of Ascaris spp. is a major antibody target in infected pigs and humans

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    BACKGROUND: The pig parasite Ascaris suum plays and important role in veterinary medicine and represents a suitable model for A. lumbricoides, which infects over 800 million people. In pigs, continued exposure to Ascaris induces immunity at the level of the gut, protecting the host against migrating larvae. The objective of this study was to identify and characterize parasite antigens targeted by this local immune response that may be crucial for parasite invasion and establishment and to evaluate their protective and diagnostic potential. METHODOLOGY/PRINCIPAL FINDINGS: Pigs were immunized by trickle infection for 30 weeks, challenged with 2,000 eggs at week 32 and euthanized two weeks after challenge. At necropsy, there was a 100% reduction in worms recovered from the intestine and a 97.2% reduction in liver white spots in comparison with challenged non-immune control animals. Antibodies purified from the intestinal mucus or from the supernatant of cultured antibody secreting cells from mesenteric lymph nodes of immune pigs were used to probe L3 extracts to identify antibody targets. This resulted in the recognition of a 12kDa antigen (As12) that is actively shed from infective Ascaris L3. As12 was characterized as a phosphorylcholine-containing glycolipid-like antigen that is highly resistant to different enzymatic and chemical treatments. Vaccinating pigs with an As12 fraction did not induce protective immunity to challenge infection. However, serological analysis using sera or plasma from experimentally infected pigs or naturally infected humans demonstrated that the As12 ELISA was able to detect long-term exposure to Ascaris with a high diagnostic sensitivity (98.4% and 92%, respectively) and specificity (95.5% and 90.0%) in pigs and humans, respectively. CONCLUSIONS/SIGNIFICANCE: These findings show the presence of a highly stage specific, glycolipid-like component (As12) that is actively secreted by infectious Ascaris larvae and which acts as a major antibody target in infected humans and pigs

    Transcriptomic analysis of Ascaris suum larvae during their hepatopulmonary migration

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    Common roundworms are important intestinal nematodes of man (Ascaris lumbricoides) and pig (Ascaris suum). During the first stages of the infection, the larvae of these parasites undergo a hepatopulmonary migration. This migration is likely to require tightly regulated transcriptional changes in the parasite. We explored this aspect in Ascaris suum by characterizing the transcription profiles of infective L3s from eggs, liver- and lung-L3s and intestinal L4s by next generation sequencing approach. When the most abundant transcripts per life stage were investigated, results showed that in the egg-L3s, transcripts associated with the regulation of translation and transcription, mainly ribosomal proteins, were most abundant. From the liver-L3s onwards, high transcription levels were seen for cuticle collagens, indicating the growth of the larvae during their migration. Interestingly, the type of highly expressed cuticle collagens in the intestinal L4s differed with those present in the liver- and lung-L3s. Apart from collagens, potentially important molecules for host-parasite interaction like C-type lectin-4 and Mucin-5 were in the top 5 of most abundant transcripts in the lung-L3. Unfortunately, a great number of transcripts that are specific for certain larval stages did not show any homology to other proteins within the NCBI database, suggesting that many biologically interesting molecules from this parasite are still to be investigated

    The Emission Structure of Formaldehyde MegaMasers

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    The formaldehyde MegaMaser emission has been mapped for the three host galaxies IC\,860. IRAS\,15107++0724, and Arp\,220. Elongated emission components are found at the nuclear centres of all galaxies with an extent ranging between 30 to 100 pc. These components are superposed on the peaks of the nuclear continuum. Additional isolated emission components are found superposed in the outskirts of the radio continuum structure. The brightness temperatures of the detected features ranges from 0.6 to 13.4 ×104\times 10^{4} K, which confirms their masering nature. The masering scenario is interpreted as amplification of the radio continuum by foreground molecular gas that is pumped by far-infrared radiation fields in these starburst environments of the host galaxies.Comment: Accepted MNRA
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