ON PERFORMANCE ANALYSIS OF AMBR PROTOCOL IN MOBILE AD HOC NETWORKS

Due to mobility of nodes in ad hoc networks, the most challenging issue is to design and to make sound analysis of a routing protocol that determines its robustness to deliver packets in low routing packet overhead. In this paper, we thoroughly analyzed the Adaptive Monitor Based Routing (AMBR) protocol by varying different parameters that affect a routing protocol to measure its performance. Analysis shows that it requires less routing control overhead comparing with other prevalent routing protocols. An improved analytical model is also presented in this paper. All these analyses firmly prove that AMBR is a sound and robust protocol in terms of flooding, routing overhead and hence, enhances reliabilit

R-charged AdS bubble

We construct R-charged adS bubbles in $D =5$, ${\cal N} =8$ supergravity. These bubbles are charecterised by four parameters. The asymptotic boundary of these solutions are deSitter times a circle. By comparing boundary energies, we study the possibility of a transition from certain class of black holes to these bubbles below a critical radius of the boundary circle. We argue that this may occur when four parameters of the bubble satisfy a constraint among themselves.Comment: 7 pages, LaTex, 2 figures, discussed stability of the soln., references added, Journal versio

Born-Infeld black holes in the presence of a cosmological constant

We construct asymptotically anti-deSitter (and deSitter) black hole solutions of Einstein-Born-Infeld theory in arbitrary dimension. We critically analyse their geometries and discuss their thermodynamic properties.Comment: 10 Pages, 6 Figures, LaTeX, to appear in Phys. Letts.

Back reaction effects on the dynamics of heavy probes in heavy quark cloud

We holographically study the effect of back reaction on the hydrodynamical properties of $\mathcal{N} = 4$ strongly coupled super Yang-Mills (SYM) thermal plasma. The back reaction we consider arises from the presence of static heavy quarks uniformly distributed over $\mathcal{N} = 4$ SYM plasma. In order to study the hydrodynamical properties, we use heavy quark as well as heavy quark-antiquark bound state as probes and compute the jet quenching parameter, screening length and binding energy. We also consider the rotational dynamics of heavy probe quark in the back-reacted plasma and analyse associated energy loss. We observe that the presence of back reaction enhances the energy-loss in the thermal plasma. Finally, we show that there is no effect of angular drag on the rotational motion of quark-antiquark bound state probing the back reacted thermal plasma.Comment: 29 pages, 21 figure

Single-cell insights into transcriptomic diversity in immunity

Our body is composed of a diverse set of cells that together perform numerous functions in a highly coordinated manner, allowing a timely response to external cues and to inter-cellular signals. Emerging single-cell technologies enable investigation of these intricate processes at an unprecedented level. Here, we discuss recent work on cellular differentiation and heterogeneity, and describe novel experimental and computational tools that enable this research. As an example of cellular differentiation, we focus on T cell development in response to diverse infections and in immune pathologies. We then describe how single-cell studies have contributed to our understanding of transcriptional variability in innate immune response, and how this variability might be important in achieving a balanced immune response. Future single-cell studies will likely include spatial analyses and lineage tracing strategies, holding great potential to further our understanding of cell behaviour in steady-state and pathological conditions.This project was supported by ERC grants (ThDEFINE and ThSWITCH) and an EU FET-OPEN grant (MRG-GRAMMAR). T.H was supported by a Human Frontier Science Program Long-Term Fellowship (LT000229/2013) and by an EMBO Long-Term fellowship (ALTF 280-2014). R.J.M. was supported by a PhD Fellowship (SFRH/BD/51950/2012) from Fundação para a Ciência e Tecnologia, Portugal.info:eu-repo/semantics/publishedVersio

Scaling single-cell genomics from phenomenology to mechanism

Three of the most fundamental questions in biology are how individual cells differentiate to form tissues, how tissues function in a coordinated and flexible fashion and which gene regulatory mechanisms support these processes. Single-cell genomics is opening up new ways to tackle these questions by combining the comprehensive nature of genomics with the microscopic resolution that is required to describe complex multicellular systems. Initial single-cell genomic studies provided a remarkably rich phenomenology of heterogeneous cellular states, but transforming observational studies into models of dynamics and causal mechanisms in tissues poses fresh challenges and requires stronger integration of theoretical, computational and experimental frameworks