Influence of Nb2O5 substitution on the structural and electrical properties of Bi3TaO7 ceramics

Herein we report the doping mechanism and impedance study of the Nb-substituted Bi3Ta1-xNbxO7 (0 ≤ x ≤ 0.5) prepared via conventional solid-state method at 900 °C over 24 h. The substitutional solid solution crystallised in a cubic fluorite structure, space group Fm-3m and with lattice parameter, a = b = c, in the range 5.4477 (±0.0037)–5.4654 (±0.0011) Å. An insignificant unit cell expansion was observed with increasing Nb2O5 content and the linear correlation between lattice parameter and composition variable showed that the Vegard's Law was obeyed. Both TGA and DTA analyses confirmed that the Bi3Ta1-xNbxO7 solid solution was thermally stable as neither phase transition nor weight loss was observed within the studied temperature range, ∼28 °C–1000 °C. The electrical conductivities of these samples were found to increase with increasing Nb concentration; the Bi3Ta0.5Nb0.5O7 exhibited the highest conductivity, ∼1.2 × 10−2 S cm−1 at 700 °C with a low activation energy of 1.03 eV

Sampled-data sliding mode observer for robust fault reconstruction: A time-delay approach

A sliding mode observer in the presence of sampled output information and its application to robust fault reconstruction is studied. The observer is designed by using the delayed continuous-time representation of the sampled-data system, for which sufficient conditions are given in the form of linear matrix inequalities (LMIs) to guarantee the ultimate boundedness of the error dynamics. Though an ideal sliding motion cannot be achieved in the observer when the outputs are sampled, ultimately bounded solutions can be obtained provided the sampling frequency is fast enough. The bound on the solution is proportional to the sampling interval and the magnitude of the switching gain. The proposed observer design is applied to the problem of fault reconstruction under sampled outputs and system uncertainties. It is shown that actuator or sensor faults can be reconstructed reliably from the output error dynamics. An example of observer design for an inverted pendulum system is used to demonstrate the merit of the proposed methodology compared to existing sliding mode observer design approaches

Development of Solar Educational Training Kit

The ability of utilize free resources of energy to generate electricity is one of the major tasks for environmentally research engineers. Numerous researches have been conducted to convert sunlight to direct current through Photovoltaic (PV) system. Nowadays PV research has become a popular study and has gained attention of many engineers and researchers due to free application, improving efficiency and high reliable energy source availability and is predicted to grow in years to come. With understanding of the aforementioned importance, PV systems aim to satisfy the growing demand for sustainable energy. This paper proposes a model of a real time grid assisted from low power direct current to high power alternating current as a solar educational training kit for an early education process to understand about the sustainability of energy conversion process. Integrating the switching concept, grid connection will only be switched on if the stored energy in the battery is insufficient to energize or supply the training kit. Programmable Integrated Circuit (PIC) is integrated into the educational training kit to enable it to display and indicates the battery voltage level as it also take part in switching between the battery and grid. In the nutshell, a simple and user friendly measurement training kit is intentionally designed for user’s handwork purposes

Fisher profiles and perceptions of sea turtle-fishery interactions: case study of East Coast Peninsular Malaysia

The paper focuses on coastal fisheries, particularly examining sea turtle-fishery interactions and determining the socioeconomic profile and perception of local fishers about sea turtle issues along the East Coast of Peninsular Malaysia.Turtle fisheries, Nature conservation, Coastal fisheries, Man-induced effects, ISEW, Malaysia, Malaya, Pahang, Malaysia, Malaya, Kelantan, Malaysia, Malaya, Terengganu,

Variational approximation for mixtures of linear mixed models

Mixtures of linear mixed models (MLMMs) are useful for clustering grouped data and can be estimated by likelihood maximization through the EM algorithm. The conventional approach to determining a suitable number of components is to compare different mixture models using penalized log-likelihood criteria such as BIC.We propose fitting MLMMs with variational methods which can perform parameter estimation and model selection simultaneously. A variational approximation is described where the variational lower bound and parameter updates are in closed form, allowing fast evaluation. A new variational greedy algorithm is developed for model selection and learning of the mixture components. This approach allows an automatic initialization of the algorithm and returns a plausible number of mixture components automatically. In cases of weak identifiability of certain model parameters, we use hierarchical centering to reparametrize the model and show empirically that there is a gain in efficiency by variational algorithms similar to that in MCMC algorithms. Related to this, we prove that the approximate rate of convergence of variational algorithms by Gaussian approximation is equal to that of the corresponding Gibbs sampler which suggests that reparametrizations can lead to improved convergence in variational algorithms as well.Comment: 36 pages, 5 figures, 2 tables, submitted to JCG

The accelerated path of ceritinib: Translating pre-clinical development into clinical efficacy

Abstract The discovery of anaplastic lymphoma kinase ( ALK )-rearranged non–small-cell lung cancer (NSCLC) in 2007 led to the development and subsequent approval of the ALK inhibitor crizotinib in 2011. However, despite its clinical efficacy, resistance to crizotinib invariably develops. There is now a next generation of ALK inhibitors, including two that have been approved—ceritinib and alectinib—and others that are in development—brigatinib, lorlatinib and X-396. Ceritinib and the other next-generation ALK inhibitors are more potent than crizotinib and can overcome tumor cell resistance mechanisms. Ceritinib gained US Food and Drug Administration approval in 2014 following accelerated review for the treatment of patients with ALK -positive ( ALK +) metastatic NSCLC who have progressed on or are intolerant to crizotinib. In pre-clinical studies, it demonstrated more potent inhibition of ALK than crizotinib in enzymatic assays, more durable responses in xenograft models and the ability to potently overcome crizotinib resistance mutations in vitro (including the gatekeeper mutation). There is also evidence for ceritinib penetration across the blood-brain barrier. In clinical trials, ceritinib has demonstrated durable responses and progression-free survival in ALK-inhibitor–pre-treated and –naive NSCLC patients, including high overall and intracranial response rates in those with central nervous system metastases. Selective gastrointestinal toxicity of ceritinib, such as diarrhea, nausea and vomiting is generally manageable with prophylactic medication and prompt dose reduction or interruption. Future progress in treating ALK + NSCLC will focus on determining the optimal sequencing of therapies and strategies to overcome acquired resistance, an ongoing challenge in treating ALK -mutation–driven tumors

Liberating Efimov physics from three dimensions

When two particles attract via a resonant short-range interaction, three particles always form an infinite tower of bound states characterized by a discrete scaling symmetry. It has been considered that this Efimov effect exists only in three dimensions. Here we review how the Efimov physics can be liberated from three dimensions by considering two-body and three-body interactions in mixed dimensions and four-body interaction in one dimension. In such new systems, intriguing phenomena appear, such as confinement-induced Efimov effect, Bose-Fermi crossover in Efimov spectrum, and formation of interlayer Efimov trimers. Some of them are observable in ultracold atom experiments and we believe that this study significantly broadens our horizons of universal Efimov physics.Comment: 17 pages, 5 figures, contribution to a special issue of Few-Body Systems devoted to Efimov Physic