金剛石鉆進能量與花崗巖地層風化程度的關系

Based on experimental data from a drilling process monitoring system instrumented with a hydraulic rotary drill rig in fill-weathered granite formation, the diamond penetrating energy was analyzed. The result shows that the distribution of the penetrating energy in fill-weathered granite formation agrees with that in common weathered granite formation. A negative correlation between the viscous energy, kinetic energy, total penetrating energy and the weathered degree of granite existed, and a positive correlation between the thrust force energy and the weathered degree was presented, which indicates that there is a well response between the penetrating energy and the weathered degree of rock. However, the kinetic energy, thrust force energy and viscous energy are limited in identification of formation because of different effects in various drilling modes. The specific energy of diamond drilling (SEDD) increased with the weathered degree of rock and the values of SEDD can be classified into corresponding range according to the weathered degree of rock. It is shown that the SEDD in rotary drilling is apparently less than the specific energy of percussive drilling (SEPD) in both fill soil and very strongly weathered granite formation. Reversely, the SEDD is much more than the SEPD in lightly weathered hard rock.link_to_subscribed_fulltex

Theory and approach of identification of ground interfaces based on rock drillability index

Rock drillability index is a very key parameter in selection of drill bit type and determination of productivity in petroleum, mining and geology. Unfortunately, there are many limits in the current definition as well as experimental methods. Drillability is redefined and a new concept of drillability index is brought out from analysis. Under the new concept, the drillability index is defined as penetration rate under specific energy. Based on the coupling relationship among effective thrust, rotation speed, penetration rate and drillability index, a calculation formula is established. Besides, the sensitivity of the drillability index in identification of ground layer is analyzed and its physical signification is expatiated also. The result shows that the new index overcomes the blind area in the traditional concept and can be used in continuous identification of ground layer along borehole profile.link_to_subscribed_fulltex

Interface identification in weathered granite strata based on a instrumented drilling system

A hydraulic rotary drill instrumented with a drilling process monitoring system (DPM) was used for site investigation in Hong Kong weathered granite foundation engineering. The penetrating parameters such as effective thrust force, rotational speed, flushing pressure, penetrating rate and displacement of the bit were monitored in real time. A varied slope was defined as a significant index for identification of dominative and subsidiary interfaces in the granite site. The result from t-test shows that the confidence of the DPM in identification of the geotechnical interfaces is 99%. Besides, the analysis of variation of the penetrating parameters at the interfaces indicates that there are different fluctuations at the interfaces in the curves of the parameters with borehole depth. The response degree of effective thrust force and penetrating rate to the variation of rock strength at the interfaces is 81.82% alone.link_to_subscribed_fulltex

Spin texture and magnetoroton excitations at nu=1/3

Neutral spin texture (ST) excitations at nu=1/3 are directly observed for the first time by resonant inelastic light scattering. They are determined to involve two simultaneous spin flips. At low magnetic fields, the ST energy is below that of the magnetoroton minimum. With increasing in-plane magnetic field these mode energies cross at a critical ratio of the Zeeman and Coulomb energies of eta(c)=0.020 +/- 0.001. Surprisingly, the intensity of the ST mode grows with temperature in the range in which the magnetoroton modes collapse. The temperature dependence is interpreted in terms of a competition between coexisting phases supporting different excitations. We consider the role of the ST excitations in activated transport at nu=1/3

Full length talin stimulates integrin activation and axon regeneration.

Integrin function is regulated by activation involving conformational changes that modulate ligand-binding affinity and downstream signaling. Activation is regulated through inside-out signaling which is controlled by many signaling pathways via a final common pathway through kindlin and talin, which bind to the intracellular tail of beta integrins. Previous studies have shown that the axon growth inhibitory molecules NogoA and chondroitin sulfate proteoglycans (CSPGs) inactivate integrins. Overexpressing kindlin-1 in dorsal root ganglion (DRG) neurons activates integrins, enabling their axons to overcome inhibitory molecules in the environment, and promoting regeneration in vivo following dorsal root crush. Other studies have indicated that expression of the talin head alone or with kindlin can enhance integrin activation. Here, using adult rat DRG neurons, we investigate the effects of overexpressing various forms of talin on axon growth and integrin signaling. We found that overexpression of the talin head activated axonal integrins but inhibited downstream signaling via FAK, and did not promote axon growth. Similarly, co-expression of the talin head and kindlin-1 prevented the growth-promoting effect of kindlin-1, suggesting that the talin head acts as a form of dominant negative for integrin function. Using full-length talin constructs in PC12 cells we observed that neurite growth was enhanced by the expression of wild-type talin and more so by two 'activated' forms of talin produced by point mutation (on laminin and aggrecan-laminin substrates). Nevertheless, co-expression of full-length talin with kindlin did not promote neurite growth more than either molecule alone. In vivo, we find that talin is present in PNS axons (sciatic nerve), and also in CNS axons of the corticospinal tract.This work was funded by grants from the Medical Research Council (G1000864), the Henry Smith Charity, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the European Union Framework 7 Programmes Spinal Cord Repair (201144) and Plasticise (223524), and the NIHR Cambridge Biomedical Research Centre. CLT was supported by the Merck, Sharpe and Dohme Fund. We thank Rienhardt Fassler for kindlin constructs and advice, David Critchley for talin antibodies and constructs and Mark Ginsberg for talin constructs.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.mcn.2015.03.01

On the selection and design of proteins and peptide derivatives for the production of photoluminescent, red-emitting gold quantum clusters

Novel pathways of the synthesis of photoluminescent gold quantum clusters (AuQCs) using biomolecules as reactants provide biocompatible products for biological imaging techniques. In order to rationalize the rules for the preparation of red-emitting AuQCs in aqueous phase using proteins or peptides, the role of different organic structural units was investigated. Three systems were studied: proteins, peptides, and amino acid mixtures, respectively. We have found that cysteine and tyrosine are indispensable residues. The SH/S-S ratio in a single molecule is not a critical factor in the synthesis, but on the other hand, the stoichiometry of cysteine residues and the gold precursor is crucial. These observations indicate the importance of proper chemical behavior of all species in a wide size range extending from the atomic distances (in the AuI-S semi ring) to nanometer distances covering the larger sizes of proteins assuring the hierarchical structure of the whole self-assembled system

A qualitative investigation of the impact of peer to peer online support for women living with Polycystic Ovary Syndrome

Background: Polycystic Ovary Syndrome is a common, chronic condition which affects women living with the condition both physically and psychologically. Social support may be beneficial to sufferers in coping with chronic conditions and the Internet is becoming a common place for accessing social support and information. The aim of this study was to consider the experiences of women living with Polycystic Ovary Syndrome who access and participate in an online support group discussion forum dedicated to issues surrounding this condition. Methods: Fifty participants responded to a series of open-ended questions via an online survey. Results: Thematic analysis revealed a number of empowering and disempowering experiences associated with online support group participation. The empowering processes reported by members of the group included: Connecting with others who understand; Access to information and advice; Interaction with healthcare professionals; Treatment-related decision making; Improved adjustment and management. In terms disempowering processes, only two were described by group participants: Reading about the negative experiences of others and Feeling like an outsider. Conclusions: For women living with Polycystic Ovary Syndrome, participation within an online support group may help to empower them in a range of important ways however, there may be some disempowering consequences