Effects of Cyclodextrin Type on Vitamin C, Antioxidant Activity, and Sensory Attributes of a Mandarin Juice Enriched with Pomegranate and Goji Berries

The effects of the addition of cyclodextrins (CDs), β-CD, or HP-β-CD (1%), on the protection of antioxidant compounds of mandarin juices enriched with pomegranate extract and goji berries juice, was studied. Juices were prepared and after their thermal treatment (98 ◦C, 30 s) they were stored at 4 ◦C during 75 d. Vitamin C content, CIE L∗a∗b∗ color, antioxidant capacity, retinol equivalents, and sensory properties were studied. Losses on vitamin C were higher (6%) for juices with β-CD than juices with HP-β-CD. Retinol equivalents degradation was lower (3.4%) in juices with HP-β-cyclodextrins than in those treated with β-CD. Lower losses were observed for the instrumental and sensory color intensity in juices with HP-β-CD addition. Finally, the antioxidant capacity was also higher in juices treated with HP-β-CD. Finally, the overall sensory quality of juices with HP-β-CD was the best one after 30 d of cold storage. Even though β-CD addition did not cause any improvement compared with control juice (without CD addition), the benefits of adding HP-β-CD to this particular juice were shown in almost all parameters under study.Ciencias de la Alimentació

Collaborative Challenges Between Educational Accessibility Coordinators and Adjunct Faculty in Supporting Autism Spectrum Students

Accessibility of educational accommodations has increased but can be frequently inconsistent for undergraduates with autism spectrum disorder (ASD). The didactic relationship between educational accessibility staff with faculty, who are increasingly adjuncts, facilitates many course-learning accommodations. This descriptive phenomenological study explored the perceptions and professional experiences of educational accessibility coordinators with adjunct faculty in their implementation of learning accommodation for undergraduates with ASD. Findings from this study suggested that accessibility coordinators negotiated expectations of unprepared adjunct faculty and ASD students to address issues throughout the semester. Coordinators believed ASD students struggled to navigate their experiences with adjunct professors because they were not ready for college and felt adjunct professors were unlikely to cooperate and partner because of their lack of understanding and the limitations presented by their short-term employment. Implications for practice included suggestions for increased collaboration and professional development

Information Governance Framework: The Defense Manufacturing Case Study

While many companies are facing problems with the information explosion, others are ensuring the appropriate value, quality and compliance of their information environment. Information governance is a set of standards, guidelines and accountability controls designed to ensure value, quality and compliance of information. Thus, the aim of this paper is to analyze how value, quality and compliance of information are defined in its information environment. A qualitative research is made, by a case study in a defense manufacturing company. The information governance foundations are explained, through theories from economics of information. Also, a framework was proposed plus three research propositions. In addition, this case study investigates a unified governance framework, which incorporates corporate governance, information technology governance and information governance. Therefore, two propositions were supported and one was partly supported. The main contribution of this paper is to identify and analyze dimensions and elements of information governance

Evaluación de la diversidad de Quirópteros en el Paisaje Terrestre Protegido Mesas de Moropotente.

Se describe y compara la riqueza y diversidad de murciélagos en los bosques de carbón, bosque de roble, bosque de galería y huerto caseros (clasificado como un sistema agroforestal simultánea) en el Paisaje terrestre Protegido Mesas de Moropotente en el Departamento de Estelí. Comparando dos épocas del año (Invierno- Verano) en diferentes estaciones de muestreos. Se capturaron un total de 323 especímenes, pertenecientes a tres familias, 16 géneros y 25 especies. Las especies más abundante fueron Artibeus jamaicensis, Dermanura phaeotis, Desmodus rotundus y Artibeus lituratus. De acuerdo con sus hábitos alimenticios se encontraron cuatro gremios tróficos: murciélagos frugívoros, insectívoros, nectarívoros, y hematófagos. Diversidad α el valor más alto fue en la época de invierno en la estación 1 bosque con dominancia de la especie del carbón (Acacia pennatual) (H’= 2.061). Mostró baja semejanza entre los tipos de bosque, lo cual podría deberse a las condiciones en los sitios de captur

Učinci imidazolijevih i kloriranih bispiridinijevih oksima povezani s njihovom toksičnosti na stanicama SH-SY5Y

Current research has shown that several imidazolium and chlorinated bispyridinium oximes are cytotoxic and activate different mechanisms or types of cell death. To investigate this further, we analysed interactions between these oximes and acetylcholine receptors (AChRs) and how they affect several signalling pathways to find a relation between the observed toxicities and their effects on these specific targets. Chlorinated bispyridinium oximes caused time-dependent cytotoxicity by inhibiting the phosphorylation of STAT3 and AMPK without decreasing ATP and activated ERK1/2 and p38 MAPK signal cascades. Imidazolium oximes induced a time-independent and significant decrease in ATP and inhibition of the ERK1/2 signalling pathway along with phosphorylation of p38 MAPK, AMPK, and ACC. These pathways are usually triggered by a change in cellular energy status or by external signals, which suggests that oximes interact with some membrane receptors. Interestingly, in silico analysis also indicated that the highest probability of interaction for all of our oximes is with the family of G-coupled membrane receptors (GPCR). Furthermore, our experimental results showed that the tested oximes acted as acetylcholine antagonists for membrane AChRs. Even though oxime interactions with membrane receptors need further research and clarification, our findings suggest that these oximes make promising candidates for the development of specific therapies not only in the field of cholinesterase research but in other fields too, such as anticancer therapy via altering the Ca2+ flux involved in cancer progression.Praćenjem učinka odabranih imidazolijevih i kloriranih bispiridinijevih oksima utvrđeno je da uzrokuju citotoksičnost i aktiviraju različite mehanizme ili tipove stanične smrti. Kako bismo to detaljnije istražili, analizirali smo aktivaciju nekoliko signalnih putova, kao i interakcije acetilkolinskih receptora (AChR) s navedenim oksimima te procijenili može li se opaženi toksični učinak objasniti njihovim utjecajem na ove specifične mete. Rezultati su pokazali da su klorirani bispiridinijevi oksimi prouzročili vremenski-ovisnu citotoksičnost, bez smanjenja razine ATP-a uz aktivaciju ERK1/2 i p38 MAPK-vezanih signalnih kaskada i inhibiciju fosforilacije STAT3 i AMPK proteina. Imidazolijevi oksimi djelovali su vremenski neovisno, uz značajno smanjenje razine ATP-a i inhibiciju ERK1/2 signalnog puta te fosforilaciju p38 MAPK, AMPK i ACC proteina. Navedeni signalni putovi obično se aktiviraju ili promjenom unutarnjega staničnog statusa, osobito energetskoga, ili vanjskim signalima, što upućuje na moguće interakcije oksima s nekim membranskim receptorima. Zanimljivo, in silico analizom procijenjeno je da je najvjerojatnija interakcija testiranih oksima s porodicom G-protein-spregnutih membranskih receptora (GPCR). K tomu, eksperimentalno je potvrđeno da testirani oksimi djeluju kao mogući antagonisti acetilkolina za vezanje na membranske AChR, potvrđujući tako i računalnu in silico procjenu. Iako interakcije ispitanih oksima s membranskim receptorima treba dodatno potvrditi, takve bi ih interakcije učinile kandidatima za razvoj specifičnih terapija u drugim područjima istraživanja, osim u istraživanjima povezanima s kolinesterazama, npr. kao moguće protutumorske lijekove, putem utjecaja na fluks iona Ca2+ uključenoga u progresiju tumora

Many-body approach to superfluid nuclei in axial geometry

Starting from a general many-body fermionic Hamiltonian, we derive the equations of motion (EOM) for nucleonic propagators in a superfluid system. The resulting EOM is of the Dyson type formulated in the basis of Bogoliubov's quasiparticles. As the leading contributions to the dynamical kernel of this EOM in strongly-coupled regimes contain phonon degrees of freedom in various channels, an efficient method of calculating phonon's characteristics is required to successfully model these kernels. The traditional quasiparticle random phase approximation (QRPA) solvers are typically used for this purpose in nuclear structure calculations, however, they become very prohibitive in non-spherical geometries. In this work, by linking the notion of the quasiparticle-phonon vertex to the variation of the Bogoliubov's Hamiltonian, we show that the recently developed finite-amplitude method (FAM) can be efficiently employed to compute the vertices within the FAM-QRPA. To illustrate the validity of the method, calculations based on the relativistic density-dependent point-coupling Lagrangian are performed for the single-nucleon states in heavy and medium-mass nuclei with axial deformations. The cases of $^{38}$Si and $^{250}$Cf are presented and discussed.Comment: Article: 11 pages, 6 figure

Modeling human endometrial decidualization from the interaction between proteome and secretome

CONTEXT: Decidualization of the human endometrium, which involves morphological and biochemical modifications of the endometrial stromal cells (ESCs), is a prerequisite for adequate trophoblast invasion and placenta formation. OBJECTIVE: This study aims to investigate the proteome and secretome of in vitro decidualized ESCs. These data were combined with published genomic information and integrated to model the human decidualization interactome. DESIGN: Prospective experimental case-control study. SETTING: A private research foundation. PATIENTS: Sixteen healthy volunteer ovum donors. INTERVENTION: Endometrial samples were obtained, and ESCs were isolated and decidualized in vitro. MAIN OUTCOME MEASURES: Two-dimensional difference in-gel electrophoresis, matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry, Western blot, human protein cytokine array, ELISA, and bioinformatics analysis were performed. RESULTS: The proteomic analysis revealed 60 differentially expressed proteins (36 over- and 24 underexpressed) in decidualized versus control ESCs, including known decidualization markers (cathepsin B) and new biomarkers (transglutaminase 2, peroxiredoxin 4, and the ACTB protein). In the secretomic analysis, a total of 13 secreted proteins (11 up- and 2 down-regulated) were identified, including well-recognized markers (IGF binding protein-1 and prolactin) and novel ones (myeloid progenitor inhibitory factor-1 and platelet endothelial cell adhesion molecule-1). These proteome/secretome profiles have been integrated into a decidualization interactome model. CONCLUSIONS: Proteomic and secretomic have been used as hypothesis-free approaches together with complex bioinformatics to model the human decidual interactome for the first time. We confirm previous knowledge, describe new molecules, and we have built up a model for human in vitro decidualization as invaluable tool for the diagnosis, therapy, and interpretation of biological phenomena.The participation of T.G.-G. was supported by a grant of the Ministry of Education and Science AP2007-04066 (FPU). CNIC was supported by the Spanish Ministry of Science and Innovation and the Pro-CNIC Foundation.S