Epizootiološko-epidemiološki značaj parazitskih infekcija divljih kanida

The family of wild canids belongs to the order Carnivora and comprises 16 genuses that are distributed in most countries all over the world. The most important endoparasitic diseases of wild canids are toxocariasis, uncinariasis, capillariasis, trichinellosis, echinococcosis, cestodiasis, opisthorchiasis, and alariasis. Ectoparasites that most often exist as parasites in wild canids are mites, fleas, ticks and scabies.Wild canids have a large epizootiological-epidemiological significance since they are hosts to parasites that cause certain vector diseases, the most important of which are leishmaniasis, ehrilichiosis, babesiasis, borreliosis, dirofilariasis, bartonellosis, and hepatozoonosis. The increased frequency of interaction between domestic and wild canids steps up the risk of the appearance, spread, and maintaining of the disease in domestic dog populations. Observed from the aspect of the biological and ecological risk, that can be caused by zoonotic infections, the knowledge of the etiology and epizootiology of parasistic infections of wild canids is of particular importance for the region of the Republic of Serbia.Familija divljih kanida pripada redu Carnivora (mesojedi) i obuhvata 16 rodova, koji su rasprostranjeni u većini zemalja sveta. Najznač ajnije endoparazitoze divljih kanida su toksokaroza, uncinarioza, kapilarioza, trihineloza, ehinokokoza, cestodoze, opistorhoza i alarioza. Ektoparaziti koji najčešće parazitiraju kod divljih kanida su krpelji, buve, pavaši i šugarci. Divlje kanide imaju veliki epizootiološko-epidemiološ ki značaj, s obzirom na to da kod njih parazitiraju uzročnici izvesnih vektorskih bolesti, od kojih su najvažnije lajšmanioza, erlihioza, babezioza, borelioza, dirofilarioza, bartoneloza i hepatozoonoza. Poveć anje učestalosti interakcije između domaćih i divljih kanida, poveć ava i rizik za pojavu, širenje i održavanje bolesti kod populacije domaćih pasa. Posmatrano sa aspekta biološkog i ekološkog rizika, koji može biti prouzrokovan zoonoznim infekcijama, poznavanje etiologije i epizootiologije parazitskih infekcija divljih kanida, od posebnog je značaja za region države Srbije

Dermokozmetički preparati za negu kože u menopauzi

As one of the largest organs of the body, the skin is significantly affected by the aging process and menopause. Among others regulatory elements, the estrogen receptor has been detected on the cellular components of the skin. Accordingly, dermal cellular metabolism is influenced by the hypoestrogenoemic state of menopause leading to changes in the collagen content, alterations in the concentration of glycoaminoglycans and most importantly the water content. Clinically, aging may be manifested as wrinkles, skin roughness and dryness, irregular pigmentation, telangiectasia, sallowness and brown spots (lentigines). Wrinkles and telangiectasia are associated with increased risks of actinic keratoses and nonmelanoma skin cancer. For these reasons it is enormously important to use well-designed preparations for everyday cleansing, care and protection. Contemporary preparations contain new biodegradable mild surfactants which are skin- and environmentally-friendly. Also, they include numerous actives: phytosteroids, chosen fats and oils, retinoids, cc-hydroxy acids, non-enzymatic and enzymatic antioxidants (SOD, vitamins E and C, p-caroten, coenzyme Q10, polyphenols), humectant and emollient moisturisers (pseudocollagen, hyaluronic acid, ceramides, Aloe vera gel...). Additionally, most of these preparations should encompass UV-filters and physical blockers (SPF 4 to 12)

Обједињена анализа електроенергетске и мреже даљинског система грејања

Енергетски систем на нивоу града са временом постаје све сложенији и разноликији. Различити носиоци енергије међусобно су повезани ради испуњавања различитих енергетских потреба. Уобичајени начин распрегнуте анализе енергетских мрежа не одсликава праву природу заједничког рада енергетског система. Као пример повезаних система може да послужи систем даљинског грејања и електро дистрибутивне мреже. Везу између ова два система могу да представљају CHP јединице, топлотне пумпе и електрични бојлери. У овом раду је приказан декомпоновани електро хидро–термални прорачун

Ex vivo and in vivo antioxidant activity of β-hydroxy-β-arylalkanoic acids

The interplay between oxidative stress and inflammation is implicated in many chronic diseases including Alzheimer`s disease, cardiovascular diseases, diabetes and cancer. Thirteen β-hydroxy-β-arylalkanoic acids were previously synthesized and evaluated for their anti-inflammatory activity. The aim of this study was to asses ex vivo antioxidant activity of synthesized acids, as well as ibuprofen and to identify the compounds with the most promising results for further investigation on their capacity to counteract in vivo oxidative stress triggered by inflammation. The antioxidant potential of tested compounds was evaluated by determining the concentrations of total antioxidative status, total oxidative status, prooxidant antioxidant balance and the total sulfhydryl groups. Z score statistics were used to calculate the summary scores for antioxidative activity, prooxidative activity and oxy score. The tested compounds and ibuprofen demonstrated mild prooxidative activity ex vivo. Seven acids with substituents on one benzene ring exhibited better results than ibuprofen and were selected for in vivo testing. In vivo results demonstrated better antioxidant protection compared to ex vivo results. Compound g which contains nitro group on the benzene ring demonstrated the lowest oxy score, and four compounds exhibited better results than ibuprofen

Serbian Citizens’ Opinion on the COVID-19 Epidemic

Aim: The Centre for International Public Policy has undertaken a public opinion research in which we tested the opinions of the citizens of Serbia on the coronavirus epidemic. The respondents had the opportunity to express their opinion on measures undertaken by the Serbian Government to combat the virus, to state their trust in the media, as well as the health system in general. In addition, we tested the prevalence of different conspiracy theories among citizens, whether the pandemic gave China a new image in the minds of the people and, most importantly, the level of solidarity among Serbian citizens as well as within the European / international community as a whole. Methods: In seven days, from 8-15th April 2020, we gathered a convenient sample of N=5989 respondents, which makes this the largest public opinion research project in Serbia on the topic of COVID-19 since the start of the epidemic. The electronic questionnaire consisted of 24 questions of mixed and closed type. Results: The findings of this research suggest that citizens of Serbia are not afraid of COVID-19, but are nevertheless cautious (86%). The percentage of those willing to consult a doctor when they notice any symptoms lies at 70%. Half of the respondents do not believe in alternative theories regarding the origin of the COVID-19 virus. The majority of the respondents (55%) hold government officials accountable for spreading panic through public speeches and daily public addresses. Moreover, 60% of the respondents do not trust the Serbian media outlets that are currently reporting on the COVID-19 pandemic. Furthermore, over half of the respondents are prepared to report their neighbour when he or she is coming from abroad and violates the obligation to self-isolate. However, mostly due to the significant fines, 65% of the respondents would not report the elderly when they are breaking the limited-movement restriction measures. Conclusion: As before the epidemic, opinions of the Serbian population on current topics are somewhat polarized. Although the majority of the respondents are cautious, a significant number also believes in conspiracy theories and does not fully trust the information provided by the media or the government.                                                                               &nbsp

Serbian Citizens’ Opinion on the COVID-19 Epidemic

Aim: The Centre for International Public Policy has undertaken a public opinion research in which we tested the opinions of the citizens of Serbia on the coronavirus epidemic. The respondents had the opportunity to express their opinion on measures undertaken by the Serbian Government to combat the virus, to state their trust in the media, as well as the health system in general. In addition, we tested the prevalence of different conspiracy theories among citizens, whether the pandemic gave China a new image in the minds of the people and, most importantly, the level of solidarity among Serbian citizens as well as within the European / international community as a whole. Methods: In seven days, from 8-15th April 2020, we gathered a convenient sample of N=5989 respondents, which makes this the largest public opinion research project in Serbia on the topic of COVID-19 since the start of the epidemic. The electronic questionnaire consisted of 24 questions of mixed and closed type. Results: The findings of this research suggest that citizens of Serbia are not afraid of COVID-19, but are nevertheless cautious (86%). The percentage of those willing to consult a doctor when they notice any symptoms lies at 70%. Half of the respondents do not believe in alternative theories regarding the origin of the COVID-19 virus. The majority of the respondents (55%) hold government officials accountable for spreading panic through public speeches and daily public addresses. Moreover, 60% of the respondents do not trust the Serbian media outlets that are currently reporting on the COVID-19 pandemic. Furthermore, over half of the respondents are prepared to report their neighbour when he or she is coming from abroad and violates the obligation to self-isolate. However, mostly due to the significant fines, 65% of the respondents would not report the elderly when they are breaking the limited-movement restriction measures. Conclusion: As before the epidemic, opinions of the Serbian population on current topics are somewhat polarized. Although the majority of the respondents are cautious, a significant number also believes in conspiracy theories and does not fully trust the information provided by the media or the government.                            &nbsp

Multielement determination using inductively coupled plasma optical emission spectrometry for metal characterization of water from artesian wells in Semberija region: Multivariate analysis of data

The concentrations of fifteen metals (Mg, Na, Ca, K, Se, Zn, Mn, Fe, Pb, Cr, Cu, Cd, Sb, Ni, Co) were determined in water from ten artesian wells (AW) in Semberija to obtain a general metal profile of water in this region. Principal components analysis (PCA) was used in this classification. Using principal component analysis two factors controlling the metal variability were obtained, which accounted for nearly 71.5% of the total variance. Natural (lithogenic) factor is represented by PC1, while anthropogenic factor is represented by PC2. PC1 with high contribution of Mn, Mg, Na, K, Ca, Zn and Se accounting for 41.84% of the total variance, while PC2 exhibits high loading for Cd, Ni, Sb, Cr and Pb (29.66%). Three general areas (clusters) with different metal characteristics were detected. Water from artesian wells in first cluster (AW1, AW2, AW3, AW4, AW5 and AW6) had much higher metal concentration compared with those in the second (AW7, AW8 and AW9) and third cluster (AW10). That is as a result of anthropogenic inputs. Also, the analysis of water demonstrated slightly elevated values for Mn (concentrations up to 0.176 mg/L), while concentrations of the other investigated elements are below the values recommended by the World Health Organization (WHO) and the United States Environmental Protection Agency (US EPA). [Projekat Ministarstva nauke Republike Srbije, br. 172047

Negative modulation of alpha(5) GABA(A) receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion

Reportedly, negative modulation of alpha(5) GABA(A) receptors may improve cognition in normal and pharmacologically-impaired animals, and such modulation has been proposed as an avenue for treatment of cognitive symptoms in schizophrenia. This study assessed the actions of PWZ-029, administered at doses (2, 5, and 10 mg/kg) at which it reached micromolar concentrations in brain tissue with estimated free concentrations adequate for selective modulation of alpha(5) GABA(A) receptors, in three cognitive tasks in male Wistar rats acutely treated with the noncompetitive N-methyl-D-aspartate receptor antagonist, MK-801 (0.1 mg/kg), as well in tests of locomotor activity potentiated by MK-801 (0.2 mg/kg) or amphetamine (0.5 mg/kg). In a hormetic-like manner, only 5 mg/kg PWZ-029 reversed MK-801-induced deficits in novel object recognition test (visual recognition memory), whereas in the Morris water maze, the 2 mg/kg dose of PWZ-029 exerted partial beneficial effects on spatial learning impairment. PWZ-029 did not affect recognition memory deficits in social novelty discrimination procedure. Motor hyperactivity induced with MK-801 or amphetamine was not preventable by PWZ-029. Our results show that certain MK-801-induced memory deficits can be ameliorated by negative modulation of alpha(5) GABA(A) receptors, and point to the need for further elucidation of their translational relevance to cognitive deterioration in schizophrenia

The effect of colour on reading performance in children, measured by a sensor hub: From the perspective of gender

In recent decades reported findings regarding gender differences in reading achievement, cognitive abilities and maturation process in boys and girls are conflicting. As reading is one of the most important processes in the maturation of an individual, the aim of the study was to better understand gender differences between primary school students. The study evaluates differences in Heart Rate Variability (HRV), Electroencephalography (EEG), Electrodermal Activities (EDA) and eye movement of participants during the reading task. Taking into account that colour may affect reading skills, in that it affects the emotional and physiological state of the body, the research attempts to provide a better understanding of gender differences in reading through examining the effect of colour, as applied to reading content. The physiological responses of 50 children (25 boys and 25 girls) to 12 different background and overlay colours of reading content were measured and summarised during the reading process. Our findings show that boys have shorter reading duration scores and a longer Saccade Count, Saccade Duration Total, and Saccade Duration Average when reading on a coloured background, especially purple, which could be caused by their motivation and by the type of reading task. Also, the boys had higher values for the Delta band and the Whole Range of EEG measurements in comparison to the girls when reading on coloured backgrounds, which could reflect the faster maturation of the girls. Regarding EDA measurements we did not find systematic differences between groups either on white or on coloured/overlay background. We found the most significant differences arose in the HRV parameters, namely (SDNN (ms), STD HR (beats/min), RMSSD (ms), NN50 (beats), pNN50 (%), CVRR) when children read the text on coloured/overlay backgrounds, where the girls showed systematically higher values on HRV measurements in comparison to the boys, mostly with yellow, red, and orange overlay colours

Supplementary data for the article: Pavlović, M.; Tadić, A.; Gligorijević, N.; Poljarević, J.; Petrović, T.; Dojčinović, B.; Savić, A.; Radulović, S.; Grgurić-Šipka, S.; Aranđelović, S. Synthesis, Chemical Characterization, PARP Inhibition, DNA Binding and Cellular Uptake of Novel Ruthenium(II)-Arene Complexes Bearing Benzamide Derivatives in Human Breast Cancer Cells. Journal of Inorganic Biochemistry 2020, 210, 111155. https://doi.org/10.1016/j.jinorgbio.2020.111155

Supplementary material for: [https://doi.org/10.1016/j.jinorgbio.2020.111155]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/4048