Building a Holistic International Educational Partnership: Collaboration Between The University of Georgia and the Tunisian Higher Education System

This article reports on a capacity building partnership between The University of Georgia and the higher education system of Tunisia that has been ongoing since 2002. The article discusses important aspects of the program, highlights the conceptual framework and underlying principles that have guided and shaped its design, and gives a comprehensive overview of its overall objectives, concrete actions, and outcomes. Our team’s response to Tunisia’s most urgent development needs; integrating institutional and national resources; building networks of decision makers, administrators, faculty, and students across disciplinary and institutional boundaries; and facilitating the development of indigenous expertise were among the attributes leading to the program’s selection for the Andrew Heiskel Award for Innovation in International Education

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Volatile fingerprinting differentiates diverse-aged craft beers

Supplementary data to this article can be found online at https:// doi.org/10.1016/j.lwt.2019.03.044.Beer ageing on wood is a complex and difficult to control process involving several reactions and compounds. Difficulties in understanding the underlying phenomena often lead to empirical and unpredictable processes and heterogeneous products. This work resorts to volatile fingerprinting along with multivariate analysis as tools to differentiate and highlight differences in beers derived from diverse production processes. Volatile composition of beers originating from barrel ageing processes and unaged beer were analyzed by GC-MS. The collected data was processed by principal component analysis, which allowed the evaluation of relations between samples and volatile compounds. Beers were distinguished by clusters comprising different groups of volatiles. Beer with the longest period in barrel was in the cluster with the most volatiles. Beer produced by resident barrel microbiota fermentation was characterized by presence of Brettanomyces sp. metabolites. Beer aged in barrel by a shorter time period showed characteristic content of ethyl esters and oak extractives. Beer produced in inox vat and beer fermented in barrel with pitching of S. cerevisiae appeared in the same cluster, relating with fermentative esters. Volatile fingerprinting was a viable approach to characterize and distinguish the analyzed beers, providing relevant information regarding the impact of production methodologies in volatile composition.This work had funding support of the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 unit and COMPETE 2020 (POCI-01-0145 FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER000004) funded by the European Regional Development Fund under the scope of Norte2020 – Programa Operacional Regional do Norte. Fermentum –EngenhariadasFermentações Lda.also participated incofunding and supplying materials for this work. Authors would like to thank Mr. Paulo Coutinho and Quinta do Portal for supplying the oak barrels used in this work.info:eu-repo/semantics/publishedVersio

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Les stratégies d'implantation en grandes et moyennes surfaces (GMS) : le cas des produits de terroir

The diversification of the offer of terroir products forces distributors to question their allocation in the store. The thesis proposes to reflect on the allocation of terroir products in the French context by adopting an inter-categorial approach, at the general level of the store. This research examines the role of shelf space allocation strategies in increasing the accessibility and ease of purchase of terroir products in-store, on the one hand, and in increasing financial performance, on the other hand. Therefore, both an exploratory qualitative study and an experiment in a store have been conducted for the categories of terroir products.La diversification de l’offre des produits de terroir oblige les distributeurs à s’interroger sur leur implantation en magasin. Cette thèse propose de réfléchir sur la décision de l’implantation des produits de terroir dans le contexte français en adoptant une approche inter-catégorielle, au niveau général du magasin. Cette recherche étudie le rôle des stratégies d’implantation dans l’accroissement de l’accessibilité et de la facilité d’achat des produits de terroir en magasin, d’une part, et dans l’augmentation de la performance financière, d’autre part. Pour ce faire, une étude qualitative exploratoire ainsi qu’une expérimentation dans un magasin ont été menées sur les catégories de produits de terroir

Strategies of shelf space allocation in grocery stores : the case of terroir products

La diversification de l’offre des produits de terroir oblige les distributeurs à s’interroger sur leur implantation en magasin. Cette thèse propose de réfléchir sur la décision de l’implantation des produits de terroir dans le contexte français en adoptant une approche inter-catégorielle, au niveau général du magasin. Cette recherche étudie le rôle des stratégies d’implantation dans l’accroissement de l’accessibilité et de la facilité d’achat des produits de terroir en magasin, d’une part, et dans l’augmentation de la performance financière, d’autre part. Pour ce faire, une étude qualitative exploratoire ainsi qu’une expérimentation dans un magasin ont été menées sur les catégories de produits de terroir.The diversification of the offer of terroir products forces distributors to question their allocation in the store. The thesis proposes to reflect on the allocation of terroir products in the French context by adopting an inter-categorial approach, at the general level of the store. This research examines the role of shelf space allocation strategies in increasing the accessibility and ease of purchase of terroir products in-store, on the one hand, and in increasing financial performance, on the other hand. Therefore, both an exploratory qualitative study and an experiment in a store have been conducted for the categories of terroir products

Vers une meilleure compréhension des stratégies d’implantation des produits de terroir en GMS: Towards a better understanding of space allocation strategies of terroir products in grocery stores

International audienceThis article explores the space allocation strategies for terroir products in grocery stores. The results confirm the existence of the three kinds of allocations identified in the literature: on a dedicated shelf, on the shelves of their products categories, and double allocation. Moreover, our research suggests that determinants, objectives and constraints related to the space allocation decision are impacted by the branding strategy, store format and terroir products category.Cette recherche explore les stratégies d’implantation des produits de terroir en GMS. Les résultats confirment l’existence des trois types d’implantation identifiés dans la littérature : dans un élément dédié, dans la catégorie des produits d’appartenance et dans la double implantation. En outre, ils suggèrent que les déterminants, objectifs et contraintes liés à la stratégie d’implantation dépendent de la stratégie de marquage, du format du magasin et de la catégorie des produits de terroir