機能性副腎皮質腫瘍ならびに非機能性副腎皮質腫瘍における腫瘍内チトクロームP-450活性に関する研究

取得学位 : 博士（医学）, 学位授与番号 : 医博乙第1329号, 学位授与年月日：平成7年1月18日,学位授与年：199

観光まちづくりと地域観光ガイドに関する研究(1)「鞆の浦しお待ちガイドの会」の取り組み

We gave an overview of the role that tourism volunteer guides play in tourism town development and investigated and verified the efforts of tourism volunteer guides in the Tomonoura district of Fukuyama City, Hiroshima Pref. The human resources who are responsible for the tourism volunteer guide in the Tomonoura area are not limited to residents in the Tomonoura area but are considered to refer to Fukuyama citizens or people who love Tomonoura. Of the tourist destinations that use natural heritage and historical heritage a s resources, the areas where corporate capital has not been invested are heavily burdened by the local community. It can be said that the expansion of tourism volunteers by "deemed" Tomo district residents, as seen in the Tomo district, has implications for other tourism town development

Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2010: General view of the pathogens\u27 antibacterial susceptibility

The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from patients in Japan, was conducted by Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases and Japanese Society for Clinical Microbiology in 2010.The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period from January and April 2010 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical and Laboratory Standard Institutes using maximum 45 antibacterial agents.Susceptibility testing was evaluable with 954 strains (206 Staphylococcus aureus, 189 Streptococcus pneumoniae, 4 Streptococcus pyogenes, 182 Haemophilus influenzae, 74 Moraxella catarrhalis, 139 Klebsiella pneumoniae and 160 Pseudomonas aeruginosa). Ratio of methicillin-resistant S.aureus was as high as 50.5%, and those of penicillin-intermediate and -resistant S.pneumoniae were 1.1% and 0.0%, respectively. Among H.influenzae, 17.6% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately resistant, 33.5% to be β-lactamase-non-producing ABPC-resistant and 11.0% to be β-lactamase-producing ABPC-resistant strains. Extended spectrum β-lactamase-producing K.pneumoniae and multi-drug resistant P.aeruginosa with metallo β-lactamase were 2.9% and 0.6%, respectively.Continuous national surveillance of antimicrobial susceptibility of respiratory pathogens is crucial in order to monitor changing patterns of susceptibility and to be able to update treatment recommendations on a regular basis

Simultaneous observations of the plasma density on the same field line by the CPMN ground magnetometers and the Cluster satellites

International audienceBy applying the cross-phase method and the amplitude-ratio method to magnetic field data obtained from two ground stations located close to each other, we can determine the frequency of the field line resonance (FLR), or the field line eigenfrequency, for the field line running through the midpoint of the two stations. From thus identified FLR frequency we can estimate the equatorial plasma mass density (p) by using the T05s magnetospheric field model [Tsyganenko, N.A., Sitnov, M.I. Modeling the dynamics of the inner magnetosphere during strong geomagnetic storms, J. Geophys. Res, 110, A03208, 2005] and the equation of Singer et al. [Singer, H.J., Southwood, D.J., Walker, R.J., Kivelson, M.G. Alfven wave resonances in a realistic magnetospheric magnetic field geometry, J. Geophys. Res. 86 (A6) 4589 4596, 1981].In this study we compare p estimated from magnetometer data at two stations in the CPMN (Circum-pan Pacific Magnetometer Network) chain, Tixie (TIK, geographic coordinates: 71.59 degrees N, 128.78 degrees E, L = 6.05) and Chokurdakh (CHD, geographic coordinates: 70.62 degrees N, 147.89 degrees E, L = 5.61), with the plasma electron number density (Ne) observed by the WHISPER (Waves of High frequency Sounder for Probing the Electron density by Relaxation) instrument onboard the Cluster satellites. For the interval of January 1, 2001 December 31, 2005, we have identified 19 events in which the Cluster spacecraft were located on the field line running through the midpoint of TIK and CHD when they observed FLR, and statistically compared the simultaneously observed 1) and Ne, although the number of events Lire limited (19). In 15 Out of the 19 events the ratio of p to Ne falls into a realistic range. it is also suggested that the contribution of heavy ions tends to increase when the magnetosphere is disturbed

Vapor-Phase Synthesis of ZIF‑8 MOF Thick Film by Conversion of ZnO Nanorod Array

ZIF-8 metal organic framework “micrometer-thick” films were constructed from ZnO precursor by a vapor-phase synthesis. The ZnO-to-ZIF-8 crystal transformation proceeded in the presence of 2-methylimidazole (Hmim) vapor. Continuous coatings of intergrown ZIF-8 crystals require control of a nucleation density. The dependence of ZnO crystal plane on the ZnO-to-ZIF-8 crystal transformation was investigated using four bulk ZnO single crystals: <i>a</i>-plane (11–20), <i>c</i>-plane (0001), <i>m</i>-plane (10–10), and <i>r</i>-plane (10–11). It was revealed that the <i>m</i>-plane (10–10) of ZnO is more effectively transformed into ZIF-8. In this work, highly oriented ZnO nanorod array film was used to provide the transport pathway of Hmim molecules and volume expansion space of ZnO-to-ZIF-8 crystal transformation for nucleation and crystal intergrowth. The high conversion of ZnO nanorod array into ZIF-8 in a short time could be achieved because (1) such mass transfer is easy due to the uniform internanorod distance being maintained during reaction and (2) the surface of the nanorod array is dominated by the highly reactive <i>m</i>-plane (10–10)