Traffic Load Effect on a Highway Bridge

Bridge plays an important role in a transportation system, and is directly linked to the country’s development as well as people’s daily living. However, it is subjected to the damaging effects of the daily traffic and freight trains. Experience shows that bridges with fundamental natural frequencies in the range f=2.0...4.0 Hz respond more strongly to the dynamic action of heavy commercial traffic than other bridges. To achieve better insight into the processes occurring during the passage of a vehicle over a highway bridge with a critical natural frequency dynamic load tests have been performed. This article is about the dynamic analysis of bridges under moving vehicles. In the first phase, dynamic equation of motion with the moving load for simply supported beam is solved by the analytical method of moments and then the results are compared with the time domain method. Secondly experimental analysis is presented in which the beam is divided into 20 stations and the deflection at mid-span is recorded while the mass moves at constant velocity through different stations with the help of oscilloscope. The result obtained is plotted in the form of graphs for different velocities of mass. Finally the dynamic amplification of displacements was extracted and compared with recommendations of current design codes

The high partial wave phenomenon of spin changing atomic transitions

The collisional transition between two highly excited atomic states with different spin is investigated theoretically. Taking helium-like n1S − n3P as an example, it is found that the transition is driven in the highly ion-ized Fe ion purely by exchange, and the cross section becomes increasingly dominated by partial waves of high orbital angular momentum as the scattering energy increases. Whereas for the near-neutral Li ion the transition is dominated by channel coupling in low partial waves. Analytical bench-marks and numerical methods are developed for the accurate calculation of the exchange integral at high angular momentum. It is shown how the partial wave and energy dependence of the collision strength for high n spin changing transitions in the highly ionized ion is related to the overlap of the extended atomic orbitals.</p

Toksikološke metode otkrivanja opojnih droga u tragovima: kromatografska, spektroskopska i biološka karakterizacija derivata ecstasyja

Analysis often reveals variability in the composition of ecstasy pills from pure 3,4-methylenedioxymethamphetamine (MDMA) to mixtures of MDMA derivatives, amphetamine, and other unidentifi ed substances. For a comprehensive toxicological analysis one needs to know all steps to MDMA synthesis which may originate impurities. The aim of this study was to synthesise and determine the chemical-physical and in vitro biological properties of a series of MDMA derivatives. 3,4-methylendioxyphenyl-2-nitropropene (MDNP) was obtained by condensation of piperonal with an excess of nitroethane in the presence of ammonium acetate. MDNP was then reduced to methylenedioxyamphetamine (MDA) by LiAlH3. All compounds were analysed using HPLC and spectroscopic technique [Raman, nuclear magnetic resonance (NMR), or infrared (IR)] at all the steps of synthesis. In addition, we assessed the biological potentials of these compounds by measuring in vitro their (i) blood cell/whole blood partition coeffi cient, (ii) binding to plasmatic proteins (Fbp), and (iii) membrane adsorption. Chemical structure was determined with antibody fl uorescence polarisation immunoassay (FPIA). This study showed the presence of solid impurities, particularly of a neurotoxic compound of Al3+ in the fi nal products. FPIA identifi ed the aminoethane group close to the substituted benzene ring, but did not detect the two major precursors of MDMA: MDNP and piperonal. Raman spectroscopy is an attractive alternative technique to characterise ecstasy pills and it can identify stereoisomeric forms such as cis-MDNP and trans-MDNP, which exhibit signals at 1650 cm-1 and 1300 cm-1, respectively.Analize često otkriju neujednačenost sastava tableta ecstasyja od čistoga 3,4-metilendioksimetamfetamina (MDMA) do mješavina njegovih derivata, amfetamina i drugih neutvrđenih tvari. Stoga je za kvalitetnu toksikološku analizu potreban uvid u sve korake sinteze MDMA, s obzirom na to da se ondje vjerojatno kriju izvori nečistoće (prekursori, katalizatori). Cilj ovog ispitivanja bio je sintetizirati derivate MDMA te napraviti njihovu kemijsko-fi zikalnu i biološku in vitro karakterizaciju. 3,4-metilendioksifenil-2-nitropropen (MDNP) dobiven je kondenzacijom piperonala u suvišku nitroetana uz dodatak amonijeva acetata. Njegovom redukcijom s pomoću LiAlH3 dobiven je 3,4-metilendioksiamfetamin (MDA). Svi spojevi iz pojedinih koraka sinteze karakterizirani su s pomoću tekućinske kromatografi je visoke djelotvornosti (HPLC) i spektroskopskih tehnika [Ramanove spektroskopije, nuklearne magnetske rezonancije (NMR-a) te infracrvene spektroskopije (IR-a)]. Usto je ocijenjen i njihov biološki učinak in vitro mjerenjem (i) koefi cijenta raspodjele krvna stanica/puna krv, (ii) vezanja za bjelančevine u plazmi (Fbp) te (iii) adsorpcije na membranu. Kemijska je struktura utvrđena s pomoću fl uorescentnoga polarizacijskog imunokemijskog testa (FPIA). Analiza je u konačnim proizvodima utvrdila prisutnost krutih nečistoća, napose spojeva neurotoksičnog aluminija (Al3+). FPIA je prepoznao aminoetansku skupinu blizu supstituiranoga benzenskog prstena, ali ne i dva glavna prekursora za MDMA: MDNP i piperonal. Posebno je zanimljiva Ramanova spektroskopija budući da (i) pruža privlačnu alternativu za karakterizaciju sastava tableta ecstasyja te (ii) može otkriti stereoizomerne cis/trans-oblike spoja poput cis-MDNP-a odnosno trans-MDNP-a, čiji se signal vidi na 1650 cm-1 odnosno 1300 cm-1

Impact of slot/pole combination on inter-turn short-circuit current in fault-tolerant permanent magnet machines

This paper investigates the influence of the slot/pole (S/P) combination on inter-turn short-circuit (SC) current in fault-tolerant permanent magnet (FT-PM) machines. A 2-D sub-domain field computational model with multi-objective genetic algorithm is used for the design and performance prediction of the considered FT-PM machines. The electromagnetic losses of machines, including iron, magnet, and winding losses are systematically computed using analytical tools. During the postprocessing stage, a 1-D analysis is employed for turn-turn fault analysis. The method calculates self-and mutual inductances of both the faulty and healthy turns under an SC fault condition with respect to the fault locations, and thus SC fault current, considering its location. Eight FT-PM machines with different S/P combinations are analyzed. Both the performance of the machine during normal operation and induced currents during a turn-turn SC fault are investigated. To evaluate the thermal impact of each S/P combination under an inter-turn fault condition, a thermal analysis is performed using finite element computation. It is shown that low-rotor-pole-number machines have a better fault tolerance capability, while high-rotor-pole-number machines are lighter and provide higher efficiency. Results show that the influence of the S/P selection on inter-turn fault SC current needs to be considered during the design process to balance the efficiency and power density against fault-tolerant criteria of the application at hand

Using stochastic model for lower financial risk management in refinery operation planning

Most Refineries historically models are deterministic, that is, they use nominal parameter values without taking into consideration the uncertainty in process, demands, refinery parameters, etc. And as a consequence, they are unable to perform risk management. In this paper a variety of methodologies for financial risk management in engineering decision have been already developed. We follow the approach presented by Barbaro and Bagajewicz (2004), who used two-stage stochastic programming model and you, can find all other approaches analyzed and discussed. The problem addressed here is that of determining the crude oil to purchase and decide on the production level of different products given predicts of demands. The profit is maximized taking into account revenues, crude oil costs, inventory costs, and lost demand costs. The model was tested using data from the Refinery owned by the State Oil Marketing Organization (SOMO) Company, Iraq. The results show that the stochastic model can forecast higher expected profit and lower risk compared to the deterministic model

Beyond community: inclusivity through spatial interventions

This article argues against the concept of integration as the main mechanism allowing various sociocultural groups to live together and instead proposes ‘radical inclusivity’ as a better, less oppressive model of a pluralistic society. Through analytical and reflective research on the non-cohesion-based approach to integration or inclusion, this article is devoted to examining the affordances and limitations of integration through various forms of spatial interventions. As an example, we will discuss the Ellesmere Green Project in Sheffield (UK) as a typical small urban regeneration executed in a highly diverse part of Sheffield. This piece aims to bring forward the significance of moving beyond the community-as-cohesion model in urban politics and planning for integration

Dramatic Shape Sensitivity of Directional Emission Patterns from Similarly Deformed Cylindrical Polymer Lasers

Recent experiments on similarly shaped polymer micro-cavity lasers show a dramatic difference in the far-field emission patterns. We show for different deformations of the ellipse, quadrupole and hexadecapole that the large differences in the far-field emission patterns is explained by the differing ray dynamics corresponding to each shape. Analyzing the differences in the appropriate phase space for ray motion, it is shown that the differing geometries of the unstable manifolds of periodic orbits are the decisive factors in determining the far-field pattern. Surprisingly, we find that strongly chaotic ray dynamics is compatible with highly directional emission in the far-field.Comment: 14 pages, 16 figures (eps), RevTeX 4, submitted to JOSA

Pig immune response to general stimulus and to porcine reproductive and respiratory syndrome virus infection: a meta-analysis approach

BACKGROUND: The availability of gene expression data that corresponds to pig immune response challenges provides compelling material for the understanding of the host immune system. Meta-analysis offers the opportunity to confirm and expand our knowledge by combining and studying at one time a vast set of independent studies creating large datasets with increased statistical power. In this study, we performed two meta-analyses of porcine transcriptomic data: i) scrutinized the global immune response to different challenges, and ii) determined the specific response to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection. To gain an in-depth knowledge of the pig response to PRRSV infection, we used an original approach comparing and eliminating the common genes from both meta-analyses in order to identify genes and pathways specifically involved in the PRRSV immune response. The software Pointillist was used to cope with the highly disparate data, circumventing the biases generated by the specific responses linked to single studies. Next, we used the Ingenuity Pathways Analysis (IPA) software to survey the canonical pathways, biological functions and transcription factors found to be significantly involved in the pig immune response. We used 779 chips corresponding to 29 datasets for the pig global immune response and 279 chips obtained from 6 datasets for the pig response to PRRSV infection, respectively. RESULTS: The pig global immune response analysis showed interconnected canonical pathways involved in the regulation of translation and mitochondrial energy metabolism. Biological functions revealed in this meta-analysis were centred around translation regulation, which included protein synthesis, RNA-post transcriptional gene expression and cellular growth and proliferation. Furthermore, the oxidative phosphorylation and mitochondria dysfunctions, associated with stress signalling, were highly regulated. Transcription factors such as MYCN, MYC and NFE2L2 were found in this analysis to be potentially involved in the regulation of the immune response. The host specific response to PRRSV infection engendered the activation of well-defined canonical pathways in response to pathogen challenge such as TREM1, toll-like receptor and hyper-cytokinemia/ hyper-chemokinemia signalling. Furthermore, this analysis brought forth the central role of the crosstalk between innate and adaptive immune response and the regulation of anti-inflammatory response. The most significant transcription factor potentially involved in this analysis was HMGB1, which is required for the innate recognition of viral nucleic acids. Other transcription factors like interferon regulatory factors IRF1, IRF3, IRF5 and IRF8 were also involved in the pig specific response to PRRSV infection. CONCLUSIONS: This work reveals key genes, canonical pathways and biological functions involved in the pig global immune response to diverse challenges, including PRRSV infection. The powerful statistical approach led us to consolidate previous findings as well as to gain new insights into the pig immune response either to common stimuli or specifically to PRRSV infection

Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon

<p>Abstract</p> <p>Background</p> <p>The use of drug combinations, including non-artemisinin-based and artemisinin-based combination therapy (ACT), is a novel strategy that enhances therapeutic efficacy and delays the emergence of multidrug-resistant <it>Plasmodium falciparum</it>. Its use is strongly recommended in most sub-Saharan African countries, namely Cameroon, where resistance to chloroquine is widespread and antifolate resistance is emerging.</p> <p>Methods</p> <p>Studies were conducted in Cameroonian children with acute uncomplicated <it>P. falciparum </it>malaria according to the standard World Health Organization protocol at four sentinel sites between 2003 and 2007. A total of 1,401 children were enrolled, of whom 1,337 were assigned to randomized studies and 64 were included in a single non-randomized study. The proportions of adequate clinical and parasitological response (PCR-uncorrected on day 14 and PCR-corrected on day 28) were the primary endpoints to evaluate treatment efficacy on day 14 and day 28. The relative effectiveness of drug combinations was compared by a multi-treatment Bayesian random-effect meta-analysis.</p> <p>Findings</p> <p>The results based on the meta-analysis suggested that artesunate-amodiaquine (AS-AQ) is as effective as other drugs (artesunate-sulphadoxine-pyrimethamine [AS-SP], artesunate-chlorproguanil-dapsone [AS-CD], artesunate-mefloquine [AS-MQ], dihydroartemisinin-piperaquine [DH-PP], artemether-lumefantrine [AM-LM], amodiaquine, and amodiaquine-sulphadoxine-pyrimethamine [AQ-SP]). AM-LM appeared to be the most effective with no treatment failure due to recrudescence, closely followed by DH-PP.</p> <p>Conclusion</p> <p>Although AM-LM requires six doses, rather than three doses for other artemisinin-based combinations, it has potential advantages over other forms of ACT. Further studies are needed to evaluate the clinical efficacy and tolerance of these combinations in different epidemiological context.</p